Advances in protein chemistry and structural biology, Год журнала: 2023, Номер unknown, С. 1 - 15
Опубликована: Янв. 1, 2023
Язык: Английский
Journal of Cellular Physiology, Год журнала: 2022, Номер 237(8), С. 3239 - 3256
Опубликована: Июнь 13, 2022
Abstract The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental autoimmune life quality change. Following this, some therapies have developed correct misalignments, such as light therapy chronobiotics. In this manuscript, we describe circadian‐related diseases so far investigated, studies reporting relevant data on topic, evidencing relationship, are included. Despite actual limitations in published work, there clear evidence correlation between disease origin/development, and, way, clock‐related emerge great progress clinical field. Future improvements interventions can lead development successful chronotherapy strategies, deeply contributing enhanced therapeutic outcomes.
Язык: Английский
Процитировано
59
NMR in Biomedicine, Год журнала: 2024, Номер 37(9), С. e5149 - e5149
Опубликована: Сен. 1, 2024
The central nervous system (CNS) lacks traditionally defined lymphatic vasculature. However, CNS tissues and barriers compartmentalize the brain, spinal cord, adjacent spaces, facilitating transmittal of fluids, metabolic wastes, immune cells, vital signals, while more conventional pathways in meninges, cervicofacial paraspinal regions transmit efflux fluid molecules to peripheral lymph nodes. Thus, a unique highly organized circulation network encompassing intraparenchymal, subarachnoid, dural, extradural segments functions unison maintain homeostasis. Pathways involved this have been under investigation for centuries continue be source considerable interest debate. Modern imaging microscopy technologies led important breakthroughs pertaining various elements circuitry exchange over past decade, thus enhancing knowledge on mechanisms mammalian maintenance disease. Yet, better understand precise anatomical routes, physiology clinical significance these pathways, potential therapeutic targets humans, conduits, flow-regulating factors, tissue effects must analyzed systematically global manner persons across age, demographical disease states. Here, we illustrate system-wide nature intermixing networks, summarize historical studies, discuss physiological similarities differences that are relevant translation evidence from mice humans. We also review Cushing's classical model cerebrospinal flow present new framework "third circulation" emphasizes previously unexplained complexities Finally, future directions field, including emerging theranostic techniques MRI studies required
Язык: Английский
Процитировано
4
JCO Precision Oncology, Год журнала: 2025, Номер 9
Опубликована: Янв. 1, 2025
PURPOSE Chronoradiobiology has emerged as a potential field of study with therapeutic implications for cancer treatment. We aimed to investigate the association between radiation chronotherapy and efficacy toxicity patients nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS Patients nonmetastatic NPC treated intensity-modulated radiotherapy in Fujian Cancer Hospital January 2017 December 2019 were included. Propensity score matching (PSM) 1:1:1 was used account selection bias. Cox regression analysis performed explore impact timing on patient survival. Sensitivity implemented determine size directional stability. RESULTS One thousand forty met inclusion criteria 332 included PSM cohort. In unmatched cohort analysis, morning exhibited significantly superior overall survival (OS) outcome (hazard ratio [HR], 0.60 [95% CI, 0.40 0.91], adjusted log-rank P = .028) than afternoon one. After it observed that individuals undergoing group (HR, 5.88 2.55 13.58], .004) night 4.81 1.91 12.11], .018) displayed tendency toward shorter OS compared group. No significant differences acute treatment-related adverse effects among three groups. Morning demonstrated consistent robustness multivariable thereby establishing an higher OS. The directionality effect across sensitivity analysis. CONCLUSION These results underscore benefits scheduling management, although prospective studies are needed confirm these findings.
Язык: Английский
Процитировано
0
Biology, Год журнала: 2025, Номер 14(1), С. 42 - 42
Опубликована: Янв. 8, 2025
Almost all organisms, from the simplest bacteria to advanced mammals, havea near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and regulated by genes as well related transcription factors. Transcription factors fundamental rhythms, influencing gene expression, behavior in plants animals, human diseases. This review examines foundational research on transcriptional regulation of emphasizing histone modifications, chromatin remodeling, Pol II pausing control. These studies have enhanced our understanding within biological importance biology health. Finally, we summarize progress challenges these three areas move field forward.
Язык: Английский
Процитировано
0
Journal of Biological Rhythms, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
The nature of biological research is changing, driven by the emergence big data, and new computational models to parse out information therein. Traditional methods remain core but are increasingly either augmented or sometimes replaced emerging data science tools. This presents a profound opportunity for those circadian researchers interested in incorporating related analyses into their plans. Here, we discuss novel sources that could be used gain real-world insights biology. We further technical considerations biologist including approaches research. conversely scientists so they can more easily identify nuggets rhythms insight might too lost through application standard done without an appreciation way shape variance complex objects. Our hope this review will make bridging disciplines both directions (biology vice versa) easier. There has never been such rapid growth cheap, accessible, opportunities biology as now; collaborations between experts skilled have potential mine with transformative impact.
Язык: Английский
Процитировано
0
Chronobiology International, Год журнала: 2025, Номер unknown, С. 1 - 13
Опубликована: Янв. 31, 2025
Research linking circadian dysregulation to cancer development has received increasing attention recently. However, a comprehensive understanding of research hotspots and trends in this area remains limited. International studies on the rhythms were retrieved downloaded from Web Science database. Bibliometric analysis visualization performed using VOSviewer, CiteSpace, HistCite. Three thousand three hundred eighteen English articles 2004 2024 screened evaluated. The increase publications citations reflected rapid expansion field. Scholars institutions United States have relatively high academic productivity impact. Chronobiology is most popular journal. Key clustering identified six themes: biochemistry molecular biology, physiology immunomodulation, night shift work health effects, physiological mental health, tumor therapy research, oxidative stress cancer-related mechanisms. Keyword burst regulation cells microenvironment as frontiers. role immunotherapy was current hotspot by reference co-citation analysis. This study reveals status predicts future trends. These findings provide new ideas for developing novel prevention treatment strategies.
Язык: Английский
Процитировано
0
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 18, 2024
Circadian rhythms, intrinsic cycles spanning approximately 24 h, regulate numerous physiological processes, including sleep–wake cycles, hormone release, and metabolism. These rhythms are orchestrated by the circadian clock, primarily located in suprachiasmatic nucleus (SCN) of hypothalamus. Disruptions whether due to genetic mutations, environmental factors, or lifestyle choices, can significantly impact health, contributing disorders such as sleep disturbances, metabolic syndrome, cardiovascular diseases. Additionally, there is a profound link between disruption development various cancer, influence on disease incidence progression. This incurred regulation clock pathways has its implication tumorigenesis, cell cycle control, DNA damage response, apoptosis, Furthermore, timing system modulates efficacy toxicity cancer treatments. In treatment, use chronotherapy optimize medical treatments, involves administering chemotherapy, radiation, other therapeutic interventions at specific intervals enhance minimize side effects. approach capitalizes variations cellular repair, progression, drug Preclinical clinical studies have demonstrated that improve index chemotherapeutic agents like cisplatin 5-fluorouracil enhancing anticancer activity reducing toxicity. Further research needed elucidate mechanisms underlying develop robust chronotherapeutic protocols tailored individual patients' profiles, potentially transforming care into more effective personalized treatment strategies.
Язык: Английский
Процитировано
2
Brain Multiphysics, Год журнала: 2024, Номер unknown, С. 100105 - 100105
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2
Current Oncology Reports, Год журнала: 2022, Номер 24(2), С. 135 - 149
Опубликована: Янв. 21, 2022
Circadian rhythms impose daily a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, DNA damage response. Accumulating epidemiological genetic evidence indicates that circadian rhythms' disruption may be linked to cancer. The integration biology into cancer research offer new options for increasing treatment effectiveness would encompass the prevention, diagnosis, this disease.In recent years, there has been significant development use multi-modal sensors monitor physical activity, sleep, rhythms, allowing, very first time, scaling accurate sleep monitoring linking patterns disease, wellness applications providing potential applications. This review highlights role clock in tumorigenesis, hallmarks introduces state-of-the-art sleep-monitoring technologies, discussing eventual application insights clinical settings research.
Язык: Английский
Процитировано
9
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8212 - 8212
Опубликована: Июль 26, 2022
The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to external environment in order maintain internal homeostasis. For functioning CC, genes (CG) act different metabolic pathways through clock-controlled (CCG), providing cellular regulation. CC's interruption result development diseases, such as neurodegenerative disorders, well cancer. Leukemias correspond group malignancies blood bone marrow occur when alterations normal regulatory cause uncontrolled proliferation hematopoietic stem cells. This review aimed associate deregulated CC with manifestation leukemia, looking for possible involving CG their role leukemic biomarkers.
Язык: Английский
Процитировано
7