Metabolism and exercise: the skeletal muscle clock takes centre stage

Nature Reviews Endocrinology, Год журнала: 2023, Номер 19(5), С. 272 - 284

Опубликована: Фев. 1, 2023

Язык: Английский

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Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial

Diabetes Care, Год журнала: 2023, Номер 46(7), С. 1417 - 1424

Опубликована: Май 25, 2023

OBJECTIVE We aimed to determine the association of time-of-day bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control across 4 years adults overweight/obesity and type 2 diabetes. RESEARCH DESIGN AND METHODS Among 2,416 participants (57% women; mean age, 59 years) 7-day waist-worn accelerometry recording at year 1 or 4, we assigned bMVPA timing groups based on participants’ temporal distribution recategorized them 4. The time-varying exposure (≥10-min bout) was defined as ≥50% occurring during same time period (morning, midday, afternoon, evening), <50% any (mixed), ≤1 day per week (inactive). RESULTS HbA1c reduction varied among (P = 0.02), independent weekly volume intensity. afternoon group had greatest versus inactive (−0.22% [95%CI −0.39%, −0.06%]), magnitude which 30–50% larger than other groups. odds discontinuation maintaining initiating glucose-lowering medications differed by 0.04). highest (odds ratio 2.13 [95% CI 1.29, 3.52]). For all year-4 groups, there were no significant between CONCLUSIONS performed is associated improvements diabetes, especially within initial 12 months an intervention. Experimental studies are needed examine causality.

Язык: Английский

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Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Окт. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Язык: Английский

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Understanding the variation in exercise responses to guide personalized physical activity prescriptions

Cell Metabolism, Год журнала: 2024, Номер 36(4), С. 702 - 724

Опубликована: Янв. 22, 2024

Язык: Английский

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Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO)

International Journal of Obesity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Multivariate analysis of NMR‐based metabolomic data

NMR in Biomedicine, Год журнала: 2021, Номер 35(2)

Опубликована: Ноя. 5, 2021

Nuclear magnetic resonance (NMR) spectroscopy allows for simultaneous detection of a wide range metabolites and lipids. As act together in complex metabolic networks, they are often highly correlated, optimal biological insight is achieved when using methods that take the correlation into account. For this reason, latent‐variable‐based methods, such as principal component analysis partial least‐squares discriminant analysis, widely used metabolomic studies. However, with increasing availability larger population cohorts, shift from spectral data to quantified metabolite levels, both more traditional statistical approaches alternative machine learning have become used. This review aims at providing an overview current state‐of‐the‐art multivariate NMR‐based well highlighting their strengths limitations.

Язык: Английский

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Clock proteins and training modify exercise capacity in a daytime-dependent manner

Proceedings of the National Academy of Sciences, Год журнала: 2021, Номер 118(35)

Опубликована: Авг. 23, 2021

Significance Studies in mice and humans have revealed daytime variance exercise performance, yet it is still unclear whether how these differences are regulated by the circadian clock. Here, we show that performance clock controlled specific proteins modify capacity a time-dependent manner, likely through food consumption liver glycogen stores. We also demonstrate time of day at which training performed plays role improving capacity. Our study suggests shaped daytime-dependent manner.

Язык: Английский

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Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Фев. 9, 2023

High carbohydrate, low fat (HCLF) diets have been the predominant nutrition strategy for athletic performance, but recent evidence following multi-week habituation has challenged superiority of HCLF over high (LCHF) diets, along with growing interest in potential health and disease implications dietary choice. Highly trained competitive middle-aged athletes underwent two 31-day isocaloric (HCLF or LCHF) a randomized, counterbalanced, crossover design while controlling calories training load. Performance, body composition, substrate oxidation, cardiometabolic, minute-by-minute glucose (CGM) biomarkers were assessed. We demonstrated: (i) equivalent high-intensity performance (@∼85%VO 2max ), fasting insulin, hsCRP, HbA 1c without significant composition changes across groups; (ii) record peak oxidation rates (LCHF:1.58 ± 0.33g/min @ 86.40 6.24%VO ; 30% subjects > 1.85 g/min); (iii) higher total, LDL, HDL cholesterol on LCHF; (iv) reduced mean/median variability LCHF. also found that mean predicted reductions LCHF, reduction LCHF rates. Interestingly, had mean, median 100 mg/dL (range: 111.68-115.19 mg/dL; consistent pre-diabetes), largest glycemic response to carbohydrate restriction. These results: challenge whether intake is superior even during shorter-duration, higher-intensity exercise; demonstrate lower may be therapeutic independently improve control, particularly those at risk diabetes; unique relationship between continuous parameters systemic metabolism.

Язык: Английский

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Metabolic Adaptations to Morning Versus Afternoon Training: A Systematic Review and Meta-analysis

Sports Medicine, Год журнала: 2023, Номер 53(10), С. 1951 - 1961

Опубликована: Июль 17, 2023

Язык: Английский

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Impact of lifestyle moderate‐to‐vigorous physical activity timing on glycemic control in sedentary adults with overweight/obesity and metabolic impairments

Obesity, Год журнала: 2024, Номер 32(8), С. 1465 - 1473

Опубликована: Июнь 10, 2024

Moderate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA on in sedentary adults with overweight/obesity and metabolic impairments.

Язык: Английский

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