Trends in Endocrinology and Metabolism,
Год журнала:
2023,
Номер
35(1), С. 23 - 30
Опубликована: Сен. 19, 2023
Exercise
has
systemic
health
benefits
through
effects
on
multiple
tissues,
with
intertissue
communication.
Recent
studies
indicate
that
exercise
may
improve
breastmilk
composition
and
thereby
reduce
the
intergenerational
transmission
of
obesity.
Even
if
is
considered
optimal
infant
nutrition,
there
evidence
for
variations
in
its
between
mothers
who
are
normal
weight,
those
obesity,
physically
active.
Nutrition
early
life
important
later-life
susceptibility
to
obesity
other
metabolic
diseases,
maternal
provide
protection
against
development
disease.
Here
we
summarize
recent
research
influence
discuss
potential
role
exercise-induced
adaptations
as
a
kick-start
prevent
childhood
Diabetes Care,
Год журнала:
2023,
Номер
46(7), С. 1417 - 1424
Опубликована: Май 25, 2023
OBJECTIVE
We
aimed
to
determine
the
association
of
time-of-day
bout-related
moderate-to-vigorous
physical
activity
(bMVPA)
with
changes
in
glycemic
control
across
4
years
adults
overweight/obesity
and
type
2
diabetes.
RESEARCH
DESIGN
AND
METHODS
Among
2,416
participants
(57%
women;
mean
age,
59
years)
7-day
waist-worn
accelerometry
recording
at
year
1
or
4,
we
assigned
bMVPA
timing
groups
based
on
participants’
temporal
distribution
recategorized
them
4.
The
time-varying
exposure
(≥10-min
bout)
was
defined
as
≥50%
occurring
during
same
time
period
(morning,
midday,
afternoon,
evening),
<50%
any
(mixed),
≤1
day
per
week
(inactive).
RESULTS
HbA1c
reduction
varied
among
(P
=
0.02),
independent
weekly
volume
intensity.
afternoon
group
had
greatest
versus
inactive
(−0.22%
[95%CI
−0.39%,
−0.06%]),
magnitude
which
30–50%
larger
than
other
groups.
odds
discontinuation
maintaining
initiating
glucose-lowering
medications
differed
by
0.04).
highest
(odds
ratio
2.13
[95%
CI
1.29,
3.52]).
For
all
year-4
groups,
there
were
no
significant
between
CONCLUSIONS
performed
is
associated
improvements
diabetes,
especially
within
initial
12
months
an
intervention.
Experimental
studies
are
needed
examine
causality.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 11, 2023
The
biological
clock
system
is
an
intrinsic
timekeeping
device
that
integrates
internal
physiology
and
external
cues.
Maintaining
a
healthy
crucial
for
life.
Disruptions
to
the
body’s
can
lead
disturbances
in
sleep-wake
cycle
abnormalities
hormone
regulation,
blood
pressure,
heart
rate,
other
vital
processes.
Long-term
have
been
linked
development
of
various
common
major
diseases,
including
cardiovascular
metabolic
disorders,
tumors,
neuropsychiatric
conditions,
so
on.
External
factors,
such
as
diurnal
rhythm
light,
significant
impact
on
clock.
Additionally,
important
non-photic
zeitgeber,
exercise
regulate
rhythms
certain
extent,
making
it
possible
become
non-drug
intervention
preventing
treating
circadian
disorders.
This
comprehensive
review
encompasses
behavioral,
physiological,
molecular
perspectives
provide
deeper
understanding
how
influences
its
association
with
related
diseases.
NMR in Biomedicine,
Год журнала:
2021,
Номер
35(2)
Опубликована: Ноя. 5, 2021
Nuclear
magnetic
resonance
(NMR)
spectroscopy
allows
for
simultaneous
detection
of
a
wide
range
metabolites
and
lipids.
As
act
together
in
complex
metabolic
networks,
they
are
often
highly
correlated,
optimal
biological
insight
is
achieved
when
using
methods
that
take
the
correlation
into
account.
For
this
reason,
latent‐variable‐based
methods,
such
as
principal
component
analysis
partial
least‐squares
discriminant
analysis,
widely
used
metabolomic
studies.
However,
with
increasing
availability
larger
population
cohorts,
shift
from
spectral
data
to
quantified
metabolite
levels,
both
more
traditional
statistical
approaches
alternative
machine
learning
have
become
used.
This
review
aims
at
providing
an
overview
current
state‐of‐the‐art
multivariate
NMR‐based
well
highlighting
their
strengths
limitations.
Proceedings of the National Academy of Sciences,
Год журнала:
2021,
Номер
118(35)
Опубликована: Авг. 23, 2021
Significance
Studies
in
mice
and
humans
have
revealed
daytime
variance
exercise
performance,
yet
it
is
still
unclear
whether
how
these
differences
are
regulated
by
the
circadian
clock.
Here,
we
show
that
performance
clock
controlled
specific
proteins
modify
capacity
a
time-dependent
manner,
likely
through
food
consumption
liver
glycogen
stores.
We
also
demonstrate
time
of
day
at
which
training
performed
plays
role
improving
capacity.
Our
study
suggests
shaped
daytime-dependent
manner.
Frontiers in Nutrition,
Год журнала:
2023,
Номер
10
Опубликована: Фев. 9, 2023
High
carbohydrate,
low
fat
(HCLF)
diets
have
been
the
predominant
nutrition
strategy
for
athletic
performance,
but
recent
evidence
following
multi-week
habituation
has
challenged
superiority
of
HCLF
over
high
(LCHF)
diets,
along
with
growing
interest
in
potential
health
and
disease
implications
dietary
choice.
Highly
trained
competitive
middle-aged
athletes
underwent
two
31-day
isocaloric
(HCLF
or
LCHF)
a
randomized,
counterbalanced,
crossover
design
while
controlling
calories
training
load.
Performance,
body
composition,
substrate
oxidation,
cardiometabolic,
minute-by-minute
glucose
(CGM)
biomarkers
were
assessed.
We
demonstrated:
(i)
equivalent
high-intensity
performance
(@∼85%VO
2max
),
fasting
insulin,
hsCRP,
HbA
1c
without
significant
composition
changes
across
groups;
(ii)
record
peak
oxidation
rates
(LCHF:1.58
±
0.33g/min
@
86.40
6.24%VO
;
30%
subjects
>
1.85
g/min);
(iii)
higher
total,
LDL,
HDL
cholesterol
on
LCHF;
(iv)
reduced
mean/median
variability
LCHF.
also
found
that
mean
predicted
reductions
LCHF,
reduction
LCHF
rates.
Interestingly,
had
mean,
median
100
mg/dL
(range:
111.68-115.19
mg/dL;
consistent
pre-diabetes),
largest
glycemic
response
to
carbohydrate
restriction.
These
results:
challenge
whether
intake
is
superior
even
during
shorter-duration,
higher-intensity
exercise;
demonstrate
lower
may
be
therapeutic
independently
improve
control,
particularly
those
at
risk
diabetes;
unique
relationship
between
continuous
parameters
systemic
metabolism.
Obesity,
Год журнала:
2024,
Номер
32(8), С. 1465 - 1473
Опубликована: Июнь 10, 2024
Moderate-to-vigorous
physical
activity
(MVPA)
improves
glucose
levels;
however,
whether
its
timing
affects
daily
glycemic
control
remains
unclear.
This
study
aims
to
investigate
the
impact
of
lifestyle
MVPA
on
in
sedentary
adults
with
overweight/obesity
and
metabolic
impairments.