Bioengineering,
Год журнала:
2025,
Номер
12(1), С. 38 - 38
Опубликована: Янв. 7, 2025
Bone
is
a
natural
mineral-organic
nanocomposite
protecting
internal
organs
and
allowing
mobility.
Through
the
ages,
numerous
strategies
have
been
developed
for
repairing
bone
defects
fixing
fractures.
Several
generations
of
repair
biomaterials
proposed,
either
based
on
metals,
ceramics,
glasses,
or
polymers,
depending
clinical
need,
maturity
technologies,
knowledge
constitution
tissue
to
be
repaired.
The
global
trend
in
implant
research
shifting
toward
osteointegrative,
bioactive
possibly
stimuli-responsive
and,
where
possible,
resorbable
implants
that
actively
promote
regeneration
tissue.
In
this
mini-review,
fundamentals
healing
materials
challenges
are
summarized
commented
with
regard
progressing
scientific
discoveries.
main
types
bone-healing
then
reviewed,
their
specific
relevance
field
reminded,
citation
reference
works.
final
part,
we
highlight
promise
hybrid
organic-inorganic
ongoing
activities
development
multifunctional
implants.
This
contribution
expected
serve
as
introduction
ever-progressing
trends
future-oriented
research.
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
199, С. 114950 - 114950
Опубликована: Июнь 7, 2023
Implantable
drug
delivery
systems
(IDDS)
are
an
attractive
alternative
to
conventional
administration
routes.
Oral
and
injectable
the
most
common
routes
for
providing
peaks
of
concentrations
in
blood
after
followed
by
concentration
decay
a
few
hours.
Therefore,
constant
is
required
keep
levels
within
therapeutic
window
drug.
Moreover,
oral
presents
challenges
due
degradation
gastrointestinal
tract
or
first
pass
metabolism.
IDDS
can
be
used
provide
sustained
prolonged
periods
time.
The
use
this
type
especially
interesting
treatment
chronic
conditions
where
patient
adherence
treatments
challenging.
These
normally
systemic
delivery.
However,
localised
maximise
amount
delivered
active
site
while
reducing
exposure.
This
review
will
cover
current
applications
focusing
on
materials
prepare
main
areas
application.
Materials Science and Engineering R Reports,
Год журнала:
2023,
Номер
156, С. 100760 - 100760
Опубликована: Ноя. 3, 2023
In
industries
as
diverse
automotive,
aerospace,
medical,
energy,
construction,
electronics,
and
food,
the
engineering
technology
known
3D
printing
or
additive
manufacturing
facilitates
fabrication
of
rapid
prototypes
delivery
customized
parts.
This
article
explores
recent
advancements
emerging
trends
in
from
a
novel
multidisciplinary
perspective.
It
also
provides
clear
overview
various
techniques
used
for
producing
parts
components
three
dimensions.
The
application
these
bioprinting
an
up-to-date
comprehensive
review
their
positive
negative
aspects
are
covered,
well
variety
materials
used,
with
emphasis
on
composites,
hybrids,
smart
materials.
updated
4D
technology,
including
biomaterial
functions,
materials,
targeted
approach
to
tissue
regenerative
medicine
(TERM)
applications.
As
foundation
anticipated
developments
TERM
applications
that
could
be
useful
successful
usage
clinical
settings,
this
examines
present
challenges
obstacles
technology.
Finally,
outlines
future
regulations
will
assist
researchers
manufacture
complex
products
exploration
potential
solutions
technological
issues.
ACS Sensors,
Год журнала:
2024,
Номер
9(4), С. 1706 - 1734
Опубликована: Апрель 2, 2024
The
development
of
advanced
technologies
for
the
fabrication
functional
nanomaterials,
nanostructures,
and
devices
has
facilitated
biosensors
analyses.
Two-dimensional
(2D)
with
unique
hierarchical
structures,
a
high
surface
area,
ability
to
be
functionalized
target
detection
at
surface,
exhibit
potential
biosensing
applications.
electronic
properties,
mechanical
flexibility,
optical,
electrochemical,
physical
properties
2D
nanomaterials
can
easily
modulated,
enabling
construction
platforms
various
analytes
targeted
recognition,
sensitivity,
selectivity.
This
review
provides
an
overview
recent
advances
in
nanostructures
used
biosensor
wearable-sensor
healthcare
health-monitoring
Finally,
advantages
2D-nanomaterial-based
several
challenges
their
optimal
operation
have
been
discussed
facilitate
smart
high-performance
future.
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
31, С. 213 - 243
Опубликована: Июнь 12, 2024
Additive
manufacturing
(AM)
has
obtained
great
attentions
in
the
productions
of
customizable
implants
with
complex
shapes
and
good
mechanical
properties.
AM
fabricated
Ti
alloy
(Ti),
stainless
steel
(SS),
cobalt
chromium
(CoCr),
iron
(Fe)
have
been
revolutionized
medical
instruments,
such
as
artificial
organs,
including
heart
stents,
drug
delivery,
scaffolds
orthopedic
implants.
However,
high
Young's
modulus,
superior
characteristic,
lack
surface
integration,
corrosions,
failed
bone
remodeling,
antibacterial
performance
are
still
incomparable
to
be
used
anatomical
structure.
This
review
studied
issue
metallic
designed
by
powder
bed
fusion
selective
laser
melting
(SLM)
techniques
on
morphology,
stress
shielding
effects,
osseointegration,
capabilities
owing
implant
failure.
The
rate
degradation
corrosion
resistance
SLM
implant,
which
would
an
impact
cell
proliferation
remodeling
between
surrounding
tissue,
were
discussed.
current
article
also
highlighted
various
parameters,
like
mechanical,
chemical,
biological
modifications,
that
might
enhance
implant.
Finally,
applications,
challenges,
opportunities,
future
developments
using
addressed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 8, 2022
With
the
continuous
progress
and
development
in
biomedicine,
metallic
biomedical
materials
have
attracted
significant
attention
from
researchers.
Due
to
low
compatibility
of
traditional
metal
implant
with
human
body,
it
is
urgent
develop
new
biomaterials
excellent
mechanical
properties
appropriate
biocompatibility
solve
adverse
reactions
caused
by
long-term
implantation.
High
entropy
alloys
(HEAs)
are
nearly
equimolar
five
or
more
elements,
huge
compositional
design
space
properties.
In
contrast,
biological
high-entropy
(Bio-HEAs)
expected
be
a
bio-alloy
for
biomedicine
due
their
tunable
This
review
summarizes
composition
system
Bio-HEAs
recent
years,
introduces
bone
adaptation,
finally
puts
forward
following
suggestions
direction
Bio-HEAs:
improve
theory
simulation
studies
design,
quantify
influence
composition,
process,
post-treatment
on
performance
Bio-HEAs,
focus
loss
under
actual
service
conditions,
hoped
that
clinical
application
medical
alloy
can
realized
as
soon
possible.
International Journal of Pharmaceutics,
Год журнала:
2022,
Номер
625, С. 122094 - 122094
Опубликована: Авг. 9, 2022
3D
printing
was
invented
thirty
years
ago.
However,
its
application
in
healthcare
became
prominent
only
recent
to
provide
solutions
for
drug
delivery
and
clinical
challenges,
is
constantly
evolving.
This
cost-efficient
technique
utilises
biocompatible
materials
used
develop
model
implants
a
greater
understanding
of
human
anatomy
diseases,
can
be
organ
transplants,
surgical
planning
the
manufacturing
advanced
systems.
In
addition,
printed
medical
devices
customised
each
patient
more
tailored
treatment
approach.
The
advantages
applications
treat
patients
with
different
eye
conditions,
advances
bioprinting
offering
novel
therapy
ophthalmology.
purpose
this
review
paper
an
in-depth
treating
ocular
conditions
cornea,
glaucoma,
retina,
lids
orbits.
Advanced Engineering Materials,
Год журнала:
2022,
Номер
25(1)
Опубликована: Авг. 24, 2022
Additive
manufacturing
has
transformed
the
perspective
of
producing
three
dimensions
(3D)
objects
toward
achieving
high
quality
in
terms
accuracy,
resolution,
and
mechanical
integrity
with
excellent
surface
finishing
little
time
compared
to
subtractive
(traditional)
production.
Vat
photopolymerization
(VPP)
additive
is
among
most
common
3D
printing
technology
used
medical
field,
academic
research,
industrial
production
parts.
Four
main
techniques
fall
under
VPP,
namely
continuous
liquid
interface
(CLIP),
daylight
polymer
(DPP),
stereolithography
(SLA),
digital
light
processing
(DLP).
The
last
two
are
focus
present
article.
precision,
unique
ability
produce
highly
complex
porous
structural
geometries,
low
cost,
structures
make
DLP
SLA
suitable
for
applications,
specifically
regenerative
medicine.
This
review
presents
recent
trend
as
research
related
bone
tissue
engineering
highlighting
biological
properties
resulting
structures.
In
addition,
mechanisms,
photocurable
materials,
working
principles
introduced.
