Ceramics International, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
RSC Advances, Journal Year: 2023, Volume and Issue: 13(50), P. 35251 - 35291
Published: Jan. 1, 2023
Nanocomposite hydrogel biomaterials represent an exciting frontier in biomedicine, offering solutions to longstanding challenges.
Language: Английский
Citations
66
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114950 - 114950
Published: June 7, 2023
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional administration routes. Oral and injectable the most common routes for providing peaks of concentrations in blood after followed by concentration decay a few hours. Therefore, constant is required keep levels within therapeutic window drug. Moreover, oral presents challenges due degradation gastrointestinal tract or first pass metabolism. IDDS can be used provide sustained prolonged periods time. The use this type especially interesting treatment chronic conditions where patient adherence treatments challenging. These normally systemic delivery. However, localised maximise amount delivered active site while reducing exposure. This review will cover current applications focusing on materials prepare main areas application.
Language: Английский
Citations
65
Materials Science and Engineering R Reports, Journal Year: 2023, Volume and Issue: 156, P. 100760 - 100760
Published: Nov. 3, 2023
In industries as diverse automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known 3D printing or additive manufacturing facilitates fabrication of rapid prototypes delivery customized parts. This article explores recent advancements emerging trends in from a novel multidisciplinary perspective. It also provides clear overview various techniques used for producing parts components three dimensions. The application these bioprinting an up-to-date comprehensive review their positive negative aspects are covered, well variety materials used, with emphasis on composites, hybrids, smart materials. updated 4D technology, including biomaterial functions, materials, targeted approach to tissue regenerative medicine (TERM) applications. As foundation anticipated developments TERM applications that could be useful successful usage clinical settings, this examines present challenges obstacles technology. Finally, outlines future regulations will assist researchers manufacture complex products exploration potential solutions technological issues.
Language: Английский
Citations
50
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 1706 - 1734
Published: April 2, 2024
The development of advanced technologies for the fabrication functional nanomaterials, nanostructures, and devices has facilitated biosensors analyses. Two-dimensional (2D) with unique hierarchical structures, a high surface area, ability to be functionalized target detection at surface, exhibit potential biosensing applications. electronic properties, mechanical flexibility, optical, electrochemical, physical properties 2D nanomaterials can easily modulated, enabling construction platforms various analytes targeted recognition, sensitivity, selectivity. This review provides an overview recent advances in nanostructures used biosensor wearable-sensor healthcare health-monitoring Finally, advantages 2D-nanomaterial-based several challenges their optimal operation have been discussed facilitate smart high-performance future.
Language: Английский
Citations
17
Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: 31, P. 213 - 243
Published: June 12, 2024
Additive manufacturing (AM) has obtained great attentions in the productions of customizable implants with complex shapes and good mechanical properties. AM fabricated Ti alloy (Ti), stainless steel (SS), cobalt chromium (CoCr), iron (Fe) have been revolutionized medical instruments, such as artificial organs, including heart stents, drug delivery, scaffolds orthopedic implants. However, high Young's modulus, superior characteristic, lack surface integration, corrosions, failed bone remodeling, antibacterial performance are still incomparable to be used anatomical structure. This review studied issue metallic designed by powder bed fusion selective laser melting (SLM) techniques on morphology, stress shielding effects, osseointegration, capabilities owing implant failure. The rate degradation corrosion resistance SLM implant, which would an impact cell proliferation remodeling between surrounding tissue, were discussed. current article also highlighted various parameters, like mechanical, chemical, biological modifications, that might enhance implant. Finally, applications, challenges, opportunities, future developments using addressed.
Language: Английский
Citations
16
Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10
Published: Sept. 8, 2022
With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to low compatibility of traditional metal implant with human body, it is urgent develop new biomaterials excellent mechanical properties appropriate biocompatibility solve adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar five or more elements, huge compositional design space properties. In contrast, biological high-entropy (Bio-HEAs) expected be a bio-alloy for biomedicine due their tunable This review summarizes composition system Bio-HEAs recent years, introduces bone adaptation, finally puts forward following suggestions direction Bio-HEAs: improve theory simulation studies design, quantify influence composition, process, post-treatment on performance Bio-HEAs, focus loss under actual service conditions, hoped that clinical application medical alloy can realized as soon possible.
Language: Английский
Citations
50
International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 625, P. 122094 - 122094
Published: Aug. 9, 2022
3D printing was invented thirty years ago. However, its application in healthcare became prominent only recent to provide solutions for drug delivery and clinical challenges, is constantly evolving. This cost-efficient technique utilises biocompatible materials used develop model implants a greater understanding of human anatomy diseases, can be organ transplants, surgical planning the manufacturing advanced systems. In addition, printed medical devices customised each patient more tailored treatment approach. The advantages applications treat patients with different eye conditions, advances bioprinting offering novel therapy ophthalmology. purpose this review paper an in-depth treating ocular conditions cornea, glaucoma, retina, lids orbits.
Language: Английский
Citations
41
Biomedical Engineering Advances, Journal Year: 2022, Volume and Issue: 4, P. 100047 - 100047
Published: July 22, 2022
This review discusses various grades of titanium biomaterials and their sustainable grindability for application in the medical field. Titanium are most commonly utilized applications due to exceptional characteristics such as high corrosion resistance biocompatibility. The presented looks at principal requirements applications, some good mechanical properties, biocompatibility, corrosion, wear processability that facilitate successful implantation implants. It types alloys commercially available and, more specifically, used applications. highlights properties different further narrows down its primary focus on advantages, shortcomings biomaterials. Machining is a difficult task inherent low thermal conductivity chemical reactivity temperatures usually results changes metallurgy surface integrity machined surface. Conventional machining, which has been main machining method, limitations related environmental hazards, cutting fluid costs, operator health issues have necessitated development machining. emphasis this placed grinding techniques MQL cryogenic nano-particle high-pressure solid lubrication grind benefits limitations. Finally, will highlight potential areas future research trends cooling methods believed be great benefit industries involved manufacturing titanium-based
Language: Английский
Citations
39
Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 373 - 373
Published: Jan. 10, 2023
The global orthopedic market is forecasted to reach US$79.5 billion by the end of this decade. Factors driving increase in are population aging, sports injury, road traffic accidents, and overweight, which justify a growing demand for implants. Therefore, it utmost importance develop bone implants with superior mechanical biological properties face improve patients’ quality life. Today, metallic still hold dominant position implant market, mainly due their resistance. However, performance might be jeopardized possible release debris, leading cytotoxic effects inflammatory responses body. Poly (ether-ether-ketone) (PEEK) biocompatible, high-performance polymer one most prominent candidates used manufacturing its similarity bone. Unfortunately, bioinert nature PEEK culminates diminished osseointegration. Notwithstanding, PEEK’s bioactivity can improved through surface modification techniques development bioactive composites. This paper overviews advantages using addresses common strategies order promote enhanced biomechanical performance.
Language: Английский
Citations
30
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 9, 2023
Abstract Machine learning (ML) has emerged as a powerful tool in the research field of high entropy compounds (HECs), which have gained worldwide attention due to their vast compositional space and abundant regulatability. However, complex structure HEC poses challenges traditional experimental computational approaches, necessitating adoption machine learning. Microscopically, can model Hamiltonian system, enabling atomic‐level property investigations, while macroscopically, it analyze macroscopic material characteristics such hardness, melting point, ductility. Various algorithms, both methods deep neural networks, be employed research. Comprehensive accurate data collection, feature engineering, training selection through cross‐validation are crucial for establishing excellent ML models. also holds promise analyzing phase structures stability, constructing potentials simulations, facilitating design functional materials. Although some domains, magnetic device materials, still require further exploration, learning's potential is substantial. Consequently, become an indispensable understanding exploiting capabilities HEC, serving foundation new paradigm Artificial‐intelligence‐assisted exploration.
Language: Английский
Citations
30