Journal of Controlled Release,
Год журнала:
2023,
Номер
362, С. 342 - 355
Опубликована: Сен. 5, 2023
Chronic
retinal
diseases,
such
as
age-related
macular
degeneration
(AMD),
are
a
major
cause
of
global
visual
impairment.
However,
current
treatment
methods
involving
repetitive
intravitreal
injections
pose
financial
and
health
burdens
for
patients.
The
development
controlled
drug
release
systems,
particularly
biological
drugs,
is
still
an
unmet
need
in
prolonging
within
the
vitreous
chamber.
To
address
this,
green
supercritical
carbon
dioxide
(scCO2)
foaming
technology
was
employed
to
manufacture
porous
poly(lactic-co-glycolic
acid)
(PLGA)-based
implants
loaded
with
dexamethasone.
desired
implant
dimensions
were
achieved
through
3D
printing
customised
moulds.
By
varying
depressurisation
rates
during
process,
different
porosities
dexamethasone
successfully
obtained.
These
demonstrated
up
four
months,
surpassing
performance
previously
developed
implants.
In
view
positive
results
obtained,
pilot
study
conducted
using
monoclonal
antibody
bevacizumab
explore
feasibility
this
preparing
intraocular
biologic
molecules.
Overall,
presents
greener
more
sustainable
alternative
conventional
manufacturing
techniques,
suited
drugs
that
susceptible
degradation
under
harsh
conditions.
Biomimetics,
Год журнала:
2024,
Номер
9(3), С. 154 - 154
Опубликована: Март 1, 2024
The
incidence
of
microbial
infections
in
orthopedic
prosthetic
surgeries
is
a
perennial
problem
that
increases
morbidity
and
mortality,
representing
one
the
major
complications
such
medical
interventions.
emergence
novel
technologies,
especially
3D
printing,
represents
promising
avenue
development
for
reducing
risk
eventualities.
There
are
already
host
biomaterials,
suitable
being
tested
antimicrobial
properties
when
they
coated
with
bioactive
compounds,
as
antibiotics,
or
combined
hydrogels
antioxidant
properties,
chitosan
metal
nanoparticles,
among
others.
materials
discussed
context
this
paper
comprise
beta-tricalcium
phosphate
(β-TCP),
biphasic
calcium
(BCP),
hydroxyapatite,
lithium
disilicate
glass,
polyetheretherketone
(PEEK),
poly(propylene
fumarate)
(PPF),
poly(trimethylene
carbonate)
(PTMC),
zirconia.
While
recent
research
results
promising,
further
required
to
address
increasing
antibiotic
resistance
exhibited
by
several
common
pathogens,
potential
fungal
infections,
toxicity
some
nanoparticles.
Other
solutions,
like
incorporation
phytochemicals,
should
also
be
explored.
Incorporating
artificial
intelligence
(AI)
certain
implants
use
AI
against
bacterial
might
represent
viable
solutions
these
problems.
Finally,
there
legal
considerations
associated
biomaterials
widespread
which
must
taken
into
account.
Hardware,
Год журнала:
2024,
Номер
2(1), С. 1 - 32
Опубликована: Янв. 26, 2024
Three-dimensional
(3D)
printing
is
a
process
in
which
materials
are
added
together
layer-by-layer
manner
to
construct
customized
products.
Many
different
techniques
of
3D
exist,
vary
used,
cost,
advantages,
and
drawbacks.
Medicine
increasingly
benefiting
from
this
transformative
technology,
the
field
ophthalmology
no
exception.
The
possible
applications
eyecare
vast
have
been
explored
literature,
such
as
3D-printed
ocular
prosthetics,
orbital
implants,
educational
anatomical
models,
well
surgical
planning
training.
Novel
drug-delivery
platforms
also
emerged
because
printing,
offering
improved
treatment
modalities
for
several
pathologies.
Innovative
research
bioprinting
viable
tissues,
including
cornea,
retina,
conjunctiva,
presenting
an
avenue
regenerative
ophthalmic
therapies
future.
Although
further
development
capabilities
suitable
required,
represents
powerful
tool
enhancing
eye
health.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 27, 2024
Abstract
Millions
of
people
require
custom
ocular
prostheses
due
to
eye
loss
or
congenital
defects.
The
current
fully
manual
manufacturing
processes
used
by
highly
skilled
ocularists
are
time-consuming
with
varying
quality.
Additive
technology
has
the
potential
simplify
manufacture
prosthetics,
but
existing
approaches
just
replace
various
degrees
craftsmanship
digital
design
and
still
substantial
expertise
time.
Here
we
present
an
automatic
end-to-end
process
for
producing
that
uses
image
data
from
anterior
segment
optical
coherence
tomography
device
considers
both
shape
appearance.
Our
approach
a
statistical
model
predict,
based
on
incomplete
surface
information
socket,
best
fitting
prosthesis
shape.
We
use
colour
characterized
healthy
fellow
determine
procedurally
generate
prosthesis’s
appearance
matches
eye.
is
manufactured
using
multi-material
full-colour
3D
printer
postprocessed
satisfy
regulatory
compliance.
demonstrate
effectiveness
our
presenting
results
10
clinic
patients
who
received
printed
prosthesis.
Compared
process,
requires
five
times
less
labour
ocularist
produces
reproducible
output.
Bioengineering,
Год журнала:
2023,
Номер
10(8), С. 910 - 910
Опубликована: Авг. 1, 2023
The
intensive
development
of
technologies
related
to
human
health
in
recent
years
has
caused
a
real
revolution.
transition
from
conventional
medicine
personalized
medicine,
largely
driven
by
bioprinting,
is
expected
have
significant
positive
impact
on
patient's
quality
life.
This
article
aims
conduct
systematic
review
bioprinting's
potential
health-related
A
literature
search
was
conducted
accordance
with
the
Preferred
Reporting
Items
for
Systematic
Reviews
and
Meta-Analyses
(PRISMA)
guidelines.
comprehensive
undertaken
using
PubMed,
Scopus,
Google
Scholar,
ScienceDirect
databases
between
2019
2023.
We
identified
some
most
benefits
bioprinting
improve
life:
part
production;
saving
millions
lives;
reducing
rejection
risks
after
transplantation;
accelerating
process
skin
tissue
regeneration;
homocellular
model
generation;
precise
fabrication
accurate
specifications;
eliminating
need
organs
donor,
thus
patient
waiting
time.
In
addition,
these
advances
greatly
benefit
cancer
treatment
other
research,
offering
medical
solutions
tailored
each
individual
that
could
increase
chance
survival
significantly
their
overall
well-being.
Although
advancements
are
still
research
stage,
encouraging
results
scientific
studies
suggest
they
verge
being
integrated
into
treatment.
progress
power
revolutionize
healthcare,
promising
profound
improving
life
potentially
transforming
field
healthcare.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1959 - 1959
Опубликована: Июль 15, 2023
Ocular
diseases,
such
as
age-related
macular
degeneration
(AMD)
and
glaucoma,
have
had
a
profound
impact
on
millions
of
patients.
In
the
past
couple
decades,
these
diseases
been
treated
using
conventional
techniques
but
also
presented
certain
challenges
limitations
that
affect
patient
experience
outcomes.
To
address
this,
biomaterials
used
for
ocular
drug
delivery,
wide
range
systems
developed.
This
review
will
discuss
some
major
classes
examples
treatment
prominent
including
implants
(biodegradable
non-biodegradable),
nanocarriers
(hydrogels,
liposomes,
nanomicelles,
DNA-inspired
nanoparticles,
dendrimers),
microneedles,
drug-loaded
contact
lenses.
We
advantages
over
approaches
with
support
from
results
clinical
trials
demonstrate
their
efficacy.
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 777 - 777
Опубликована: Июль 31, 2024
Since
three-dimensional
(3D)
bioprinting
has
emerged,
it
continuously
to
evolved
as
a
revolutionary
technology
in
surgery,
offering
new
paradigms
for
reconstructive
and
regenerative
medical
applications.
This
review
highlights
the
integration
of
3D
printing,
specifically
bioprinting,
across
several
surgical
disciplines
over
last
five
years.
The
methods
employed
encompass
recent
literature
focusing
on
innovations
applications
3D-bioprinted
tissues
and/or
organs.
findings
reveal
significant
advances
creation
complex,
customized,
multi-tissue
constructs
that
mimic
natural
tissue
characteristics,
which
are
crucial
interventions
patient-specific
treatments.
Despite
technological
advances,
paper
introduces
discusses
challenges
remain,
such
vascularization
bioprinted
tissues,
with
host
tissue,
long-term
viability
concludes
while
holds
substantial
promise
transforming
practices
enhancing
patient
outcomes,
ongoing
research,
development,
clear
regulatory
framework
essential
fully
realize
potential
future
clinical
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11769 - 11769
Опубликована: Окт. 4, 2022
Damage
to
the
retinal
pigment
epithelium,
Bruch's
membrane
and/or
tissues
underlying
macula
is
known
increase
risk
of
age-related
macular
degeneration
(AMD).
AMD
commonly
categorized
in
two
distinct
types,
namely,
nonexudative
(dry
form)
and
exudative
(wet
form).
Currently,
there
no
ideal
treatment
available
for
AMD.
Recommended
standard
treatments
are
based
on
use
vascular
endothelial
growth
factor
(VEGF),
with
disadvantage
requiring
repeated
intravitreal
injections
which
hinder
patient's
compliance
therapy.
In
recent
years,
several
synthetic
natural
active
compounds
have
been
proposed
as
innovative
therapeutic
strategies
against
this
disease.
There
a
growing
interest
development
formulations
nanotechnology
because
its
important
role
management
posterior
eye
segment
disorders,
without
injections,
furthermore,
potential
prolong
drug
release
thus
reduce
adverse
effects.
same
way,
3D
bioprinting
constitutes
an
alternative
regeneration
therapies
human
retina
restore
functions.
The
application
may
change
current
future
perspectives
patients
AMD,
especially
those
who
do
not
respond
conventional
treatment.
To
monitor
progress
disease,
images
used.
work,
we
revised
challenges
encountered
different
forms
nanoformulations,
bioprinting,
techniques
progress.
