Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 775 - 775
Опубликована: Июнь 27, 2024
Rheumatoid
arthritis
(RA)
is
a
persistent
autoimmune
disorder
that
characterized
by
joint
inflammation,
discomfort,
and
impairment.
Despite
the
existence
of
several
therapeutic
approaches,
their
effectiveness
often
restricted
may
be
linked
to
unfavorable
side
effects.
Consequently,
there
has
been
growing
interest
in
investigating
naturally
derived
compounds
as
plausible
agents
for
RA
disease.
The
objective
this
review
summarize
existing
preclinical
clinical
evidence
regarding
efficacy
extracted
plant
extracts
treatment
RA,
focusing
on
anti-inflammatory,
anti-oxidative,
immunomodulatory
properties.
Some
problems
with
using
natural
chemicals
are
uneven
quality
commercially
available
preparations
poor
bioavailability
these
compounds.
Future
investigations
should
focus
improving
formulations,
conducting
thorough
trials,
exploring
different
techniques
fully
utilize
intrinsic
potential
treating
RA.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1098 - 1098
Опубликована: Янв. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
Journal of Animal Physiology and Animal Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
ABSTRACT
Bay
laurel
(
Laurus
nobilis
)
essential
oil
is
known
for
its
antimicrobial,
anti‐inflammatory,
and
antioxidant
properties.
This
study
examined
the
effects
of
L.
(LN)
on
Nile
tilapia
Oreochromis
niloticus
under
cold
stress
conditions
(16°C).
Tilapia
(initial
weight,
5.02
±
0.02
g)
were
acclimatized
to
16°C
14
days
before
being
fed
diets
containing
0,
0.5,
1.0,
1.5,
2.0,
2.5
g/kg
LN
84
days.
The
1.5
group
exhibited
highest
final
body
weight
gain
p
≤
0.05),
while
survival
rates
peaked
at
1
g/kg.
Biometric
indices
feed
efficiency
significantly
enhanced,
particularly
0.05).
Histological
analysis
revealed
improved
intestinal
hepatic
structures
in
LN‐supplemented
groups,
although
mild
alterations
observed
2.0
Blood
biochemical
showed
increased
total
protein
reduced
cholesterol
supplemented
groups.
Immune
responses,
including
serum
lysozyme
activity
bacterial
inhibition,
enhanced
or
higher
Antioxidant
enzyme
activities,
superoxide
dismutase
(SOD)
catalase
(CAT),
0.05)
with
supplementation,
malondialdehyde
(MDA)
levels
decreased,
indicating
oxidative
stress.
Gene
expression
demonstrated
insulin‐like
growth
factor
glucose
transporter
4
oil,
tumor
necrosis
factor‐alpha
decreased
dosages.
Dietary
g/kg,
enhances
growth,
immunity,
defense
Future
studies
should
optimize
dosages
explore
broader
applications
across
species
conditions.
Thiram
is
a
widely
used
fungicide
in
agricultural
practices
as
spraying
on
crops
and
grains
storage
but
its
potential
adverse
effects
non-target
aquatic
organisms
have
raised
serious
concerns.
In
this
study,
firstly
LC50
value
of
thiram
has
been
determined
0.744
mg/L
for
the
first
time
Labeo
rohita
then,
fish
were
exposed
to
different
sub-lethal
concentrations
(40
μg/L,
80
μg/L
120
μg/L)
evaluate
tissue
growth,
oxidative
stress,
anti-oxidant
enzymes
histo-pathological
parameters
at
days-20,
40
60
experiment.
There
observed
significant
(p
<
0.05)
decrease
body
weight
while
increase
relative
absolute
weights
kidneys,
heart
brain
was
found.
Hematological
analysis
showed
leukocytes
neutrophils
lymphocytes
monocytes,
RBCs
hemoglobin
concentration
significantly
decreased.
Serum
biochemical
revealed
urea
hepatic
total
proteins,
albumin
creatinine
higher
doses
(80
thiram.
Oxidative
stress
parameters;
ROS
TBARS
increased
antioxidant
(CAT,
SOD,
POD,
GSH)
treated
groups
compared
control.
Moreover,
comet
assay
DNA
damage
isolated
cells
that
further
confirmed
by
alterations
these
tissues.
The
findings
demonstrate
severely
pollute
marine
eco-system
quite
hazardous
species
causing
severe
health
even
thus,
render
apparently
clean
water
be
unfit
animal
human
consumption.
