bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

ABSTRACT Memory generalization can be defined as the transference of conditioned fear responses to novel contexts. It happens in systems consolidation, a time-dependent reduction discrimination precision due rearrangement brain regions supporting memory retrieval. To better understand fine temporal structure this process different sexes, young adult female and male rats were trained contextual conditioning task tested or three contexts either 2, 28 45 days later. A set neutral was selected graded levels expression compared training context obtained, albeit observed only males, not females, recent test - first number sexual dimorphisms detected. This asymmetry, however, disappeared over time partial generalization, with converging similar, higher values, grouped two levels, both sexes. In all experiments, females discriminators displayed lower than apparently valuing sensory modalities. is study compare between retrieving remote memories multiple contexts, allowing several dimorphic findings.

Язык: Английский