Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory DOI Creative Commons

Fernanda N. Lotz,

Kétlyn T. Knak Guerra, Ana Paula Crestani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

ABSTRACT Memory generalization can be defined as the transference of conditioned fear responses to novel contexts. It happens in systems consolidation, a time-dependent reduction discrimination precision due rearrangement brain regions supporting memory retrieval. To better understand fine temporal structure this process different sexes, young adult female and male rats were trained contextual conditioning task tested or three contexts either 2, 28 45 days later. A set neutral was selected graded levels expression compared training context obtained, albeit observed only males, not females, recent test - first number sexual dimorphisms detected. This asymmetry, however, disappeared over time partial generalization, with converging similar, higher values, grouped two levels, both sexes. In all experiments, females discriminators displayed lower than apparently valuing sensory modalities. is study compare between retrieving remote memories multiple contexts, allowing several dimorphic findings.

Language: Английский

Why are threatening experiences remembered so well? Insights into memory strengthening from protocols of gradual aversive learning DOI Creative Commons
Patricia Tezanos, José Luís Trejo

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106145 - 106145

Published: April 1, 2025

Language: Английский

Citations

0
Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistenc DOI
Hugo Bayer, Leandro J. Bertoglio, Stephen Maren

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106198 - 106198

Published: May 1, 2025

Language: Английский

Citations

0
Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents DOI
Isabel Werle, Leandro J. Bertoglio

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 105899 - 105899

Published: Sept. 1, 2024

Language: Английский

Citations

3
Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory DOI Creative Commons

Fernanda N. Lotz,

Kétlyn T. Knak Guerra, Ana Paula Crestani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

ABSTRACT Memory generalization can be defined as the transference of conditioned fear responses to novel contexts. It happens in systems consolidation, a time-dependent reduction discrimination precision due rearrangement brain regions supporting memory retrieval. To better understand fine temporal structure this process different sexes, young adult female and male rats were trained contextual conditioning task tested or three contexts either 2, 28 45 days later. A set neutral was selected graded levels expression compared training context obtained, albeit observed only males, not females, recent test - first number sexual dimorphisms detected. This asymmetry, however, disappeared over time partial generalization, with converging similar, higher values, grouped two levels, both sexes. In all experiments, females discriminators displayed lower than apparently valuing sensory modalities. is study compare between retrieving remote memories multiple contexts, allowing several dimorphic findings.

Language: Английский

Citations

0