Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

Biomedicines, Год журнала: 2023, Номер 11(2), С. 413 - 413

Опубликована: Янв. 31, 2023

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads millions deaths all over the world. sharing genes between different types bacteria led emergence multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial by up 1000-fold increase MDR infections. absence novel potent antimicrobial compounds linked rise resistance. sparked international efforts develop new improved agents well innovative efficient techniques for administration targeting. There an evolution nanotechnology treatment prevention biofilm formation infection. development nanomaterial-based therapeutics, could overcome current pathways acquired drug resistance, hopeful strategy treating difficult-to-treat Additionally, nanoparticles’ distinct size physical characteristics enable them target biofilms treat pathogens. review highlights advances combat In addition, provides insight on mechanisms XDR infection, nanoparticles their antibacterial activity. Moreover, this considers difference free antibiotics nanoantibiotics, synergistic effect nanoantibiotics planktonic bacteria, intracellular biofilm. Finally, we will discuss strength limitations application against infection future perspectives.

Язык: Английский

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Bacterial Biofilm Formation on Biomaterials and Approaches to Its Treatment and Prevention

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11680 - 11680

Опубликована: Июль 20, 2023

Bacterial biofilms can cause widespread infection. In addition to causing urinary tract infections and pulmonary in patients with cystic fibrosis, help microorganisms adhere the surfaces of various medical devices, biofilm-associated on biomaterials such as venous ducts, joint prostheses, mechanical heart valves, catheters. Biofilms provide a protective barrier for bacteria resistance antimicrobial agents, which increases morbidity mortality patients. This review summarizes biofilm formation processes mechanisms, well main features clinically persistent caused by biofilms. Considering clinical we introduce two methods prevent treat biomaterial-related infection: antibacterial coatings surface modification biomaterials. Antibacterial depend covalent immobilization agents coating drug release combat infection, while affects adhesion behavior cells implants subsequent process altering physical chemical properties implant material surface. The advantages each strategy terms their effect, biocompatibility, limitations, application prospects are analyzed, providing ideas research directions development novel infection strategies related therapeutic materials.

Язык: Английский

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Quorum sensing-mediated microbial interactions: Mechanisms, applications, challenges and perspectives

Microbiological Research, Год журнала: 2023, Номер 273, С. 127414 - 127414

Опубликована: Май 20, 2023

Язык: Английский

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Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

Biomaterials Science, Год журнала: 2024, Номер 12(7), С. 1788 - 1800

Опубликована: Янв. 1, 2024

A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal anti-quorum sensing properties.

Язык: Английский

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Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13353 - 13383

Опубликована: Март 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Язык: Английский

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Regulation of quorum sensing for the manipulation of conjugative transfer of antibiotic resistance genes in wastewater treatment system

Water Research, Год журнала: 2024, Номер 253, С. 121222 - 121222

Опубликована: Янв. 29, 2024

Язык: Английский

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QseB/QseC: a two-component system globally regulating bacterial behaviors

Trends in Microbiology, Год журнала: 2023, Номер 31(7), С. 749 - 762

Опубликована: Фев. 26, 2023

Язык: Английский

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Bacterial Biofilm Formation on Biomaterials and Approaches to Its Treatment and Prevention

Опубликована: Июнь 30, 2023

Bacterial biofilms can cause widespread infection. In addition to causing urinary tract infections and pulmonary in patients with cystic fibrosis, help microorganisms adhere the surfaces of various medical devices, biofilm-associated on biomaterials such as venous ducts, joint prostheses, mechanical heart valves, catheters. Biofilms provide a protective barrier for bacteria resistance antimicrobial agents, which increases morbidity mortality patients. This review introduces formation process drug mechanism detail, further summarizes main characteristics clinical persistent infection caused by many methods treating biomaterial-related biofilm. provides ideas directions development new biofilm strategies related therapeutic materials.

Язык: Английский

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Staphylococcus aureus and biofilms: transmission, threats, and promising strategies in animal husbandry

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2024, Номер 15(1)

Опубликована: Март 13, 2024

Abstract Staphylococcus aureus ( S. ) is a common pathogenic bacterium in animal husbandry that can cause diseases such as mastitis, skin infections, arthritis, and other ailments. The formation of biofilms threatens exacerbates infection by allowing the bacteria to adhere pathological areas livestock product surfaces, thus triggering health crises safety issues with products. To solve this problem, review, we provide brief overview harm caused its on byproducts (meat dairy products). We also describe ways which spreads animals threats it poses industry. processes molecular mechanisms involved biofilm are then explained. Finally, discuss strategies for removal eradication husbandry, including use antimicrobial peptides, plant extracts, nanoparticles, phages, antibodies. These reduce spread help maintain improve productivity ensure ecologically sustainable development

Язык: Английский

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An Antibiotic Nanobomb Constructed from pH‐Responsive Chemical Bonds in Metal‐Phenolic Network Nanoparticles for Biofilm Eradication and Corneal Ulcer Healing

Advanced Science, Год журнала: 2024, Номер 11(22)

Опубликована: Март 15, 2024

In the treatment of refractory corneal ulcers caused by Pseudomonas aeruginosa, antibacterial drugs delivery faces drawbacks low permeability and short ocular surface retention time. Hence, novel positively-charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one-step self-assembly method based on metal-phenolic network Schiff base reaction using 3,4,5-trihydroxybenzaldehyde (THBA), ε-poly-ʟ-lysine (EPL), Cu

Язык: Английский

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