Current Opinion in Biotechnology,
Год журнала:
2024,
Номер
88, С. 103149 - 103149
Опубликована: Май 28, 2024
Single-cell
chemical
and
metabolic
imaging
technologies
provide
unprecedented
insights
into
individual
cell
dynamics,
advancing
our
understanding
of
cellular
processes,
molecular
interactions,
activities.
Advances
in
fluorescence,
Raman,
optoacoustic
(photoacoustic),
or
mass
spectrometry
methods
have
paved
the
way
to
characterize
metabolites,
signaling
molecules,
other
moieties
within
cells.
These
modalities
can
also
lead
single-cell
capabilities
by
targeting
endogenous
contrast
employing
exogenous
generation
techniques,
including
agents
that
target
specific
structure
function.
In
this
review,
we
present
key
developments,
summarize
recent
applications
interrogation
imaging,
illustrate
their
advantages,
limitations,
outlook.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 7379 - 7419
Опубликована: Янв. 16, 2023
For
decades
now,
photoacoustic
imaging
(PAI)
has
been
investigated
to
realize
its
potential
as
a
niche
biomedical
modality.
Despite
highly
desirable
optical
contrast
and
ultrasonic
spatiotemporal
resolution,
PAI
is
challenged
by
such
physical
limitations
low
signal-to-noise
ratio
(SNR),
diminished
image
due
strong
attenuation,
lower-bound
on
spatial
resolution
in
deep
tissue.
In
addition,
contrast-enhanced
faced
practical
insufficient
cell-specific
targeting
delivery
efficiency
difficulties
developing
clinically
translatable
agents.
Identifying
these
essential
the
continuing
expansion
of
field,
substantial
advances
contrast-enhancing
agents,
complemented
high-performance
acquisition
systems,
have
synergistically
dealt
with
challenges
conventional
PAI.
This
review
covers
past
four
years
research
pushing
terms
SNR/contrast,
targeted
delivery,
clinical
application.
Promising
strategies
for
dealing
each
challenge
are
reviewed
detail,
future
directions
next
generation
discussed.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Сен. 16, 2021
Neuroinflammation
play
an
important
role
in
Alzheimer’s
disease
pathogenesis.
Advances
molecular
imaging
using
positron
emission
tomography
have
provided
insights
into
the
time
course
of
neuroinflammation
and
its
relation
with
central
pathologies
patients
animal
models.
Recent
single-cell
sequencing
transcriptomics
indicate
dynamic
disease-associated
microglia
astrocyte
profiles
disease.
Mitochondrial
18-kDa
translocator
protein
is
most
widely
investigated
target
for
imaging.
New
generation
tracers
improved
performance
been
developed
evaluated
along
tau
amyloid
assessing
progression
continuum.
Given
that
not
exclusively
expressed
glia,
alternative
targets
are
under
rapid
development,
such
as
monoamine
oxidase
B,
matrix
metalloproteinases,
colony-stimulating
factor
1
receptor,
imidazoline-2
binding
sites,
cyclooxygenase,
cannabinoid-2
purinergic
P2X7
P2Y12
fractalkine
triggering
receptor
on
myeloid
cells
2,
advanced
glycation
end
products.
Promising
should
demonstrate
a
higher
specificity
cellular
locations
exclusive
expression
or
activation
status
(pro-
anti-inflammatory)
highly
specific
ligand
to
enable
vivo
brain
In
this
review,
we
summarised
recent
advances
development
outlook
promising
future.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 8 - 8
Опубликована: Янв. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
Abstract
The
greatest
obstacle
to
using
drugs
treat
brain
tumors
is
the
blood‐brain
barrier
(BBB),
making
it
difficult
for
conventional
drug
molecules
enter
brain.
Therefore,
how
safely
and
effectively
penetrate
BBB
achieve
targeted
delivery
has
been
a
challenging
research
problem.
With
intensive
in
micro‐
nanotechnology
recent
years,
nano
drug‐targeted
technologies
have
shown
great
potential
overcome
this
challenge,
such
as
inorganic
nanocarriers,
organic
polymer‐carriers,
liposomes,
biobased
carriers,
which
can
be
designed
different
sizes,
shapes,
surface
functional
groups
enhance
their
ability
tumors.
In
review,
composition
overcoming
patterns
of
are
detailed,
then
hot
topics
carriers
years
summarized,
mechanisms
action
on
factors
affecting
described
detail,
effectiveness
therapy
evaluated.
Finally,
challenges
dilemmas
developing
tumor
systems
discussed,
will
promising
future
based
micro‐nanocarriers
technology.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 20, 2023
Photoacoustic
imaging
(PAI)
is
a
successful
clinical
platform
for
management
of
cancer
and
other
health
conditions
that
has
seen
significant
progress
in
the
past
decade.
However,
translation
PAI
based
methods
are
still
under
scrutiny
as
quality
information
derived
from
PA
images
not
on
par
with
methods.
Hence,
to
improve
PAI,
exogenous
contrast
agents,
form
nanomaterials,
being
used
achieve
better
image
less
side
effects,
lower
accumulation,
improved
target
specificity.
Nanomedicine
become
inevitable
management,
it
contributes
at
every
stage
diagnosis
therapy,
surgery,
even
postoperative
care
surveillance
recurrence.
Nanocontrast
agents
have
been
developed
explored
early
diagnosis.
The
systemic
stability
specificity
nanomaterials
render
its
theranostic
property
depends
various
influencing
factors
such
administration
route
physico-chemical
responsiveness.
recent
focus
targeting
lymphatic
system
nodes
diagnosis,
they
play
vital
role
progression
metastasis.
This
review
aims
discuss
advancements
using
nanoparticles
theranostics
emphasis
progression,
metastasis,
guided
tumor
resection,
finally
drug
delivery.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(12), С. 6068 - 6099
Опубликована: Янв. 1, 2024
Combining
optoacoustics
with
other
imaging
techniques
helps
bring
its
powerful
label-free
functional
readings
and
molecular
sensitivity
into
precise
anatomical
context
while
providing
an
essential
cross-validation
against
established
methods.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 5, 2025
Photoacoustic
brain
imaging
(PABI)
has
emerged
as
a
promising
biomedical
modality,
combining
high
contrast
of
optical
with
deep
tissue
penetration
ultrasound
imaging.
This
review
explores
the
application
photoacoustic
in
tumor
imaging,
highlighting
synergy
between
nanomaterials
and
state
art
techniques
to
achieve
high-resolution
deeper
tissues.
PABI
leverages
effect,
where
absorbed
light
energy
causes
thermoelastic
expansion,
generating
waves
that
are
detected
converted
into
images.
technique
enables
precise
diagnosis,
therapy
monitoring,
enhanced
clinical
screening,
specifically
management
complex
diseases
such
breast
cancer,
lymphatic
disorder,
neurological
conditions.
Despite
integration
agents
radiation,
providing
comprehensive
overview
current
methodologies,
major
obstacles
treatment,
future
directions
for
improving
diagnostic
therapeutic
outcomes.
The
underscores
significance
robust
research
tool
medical
method,
potential
revolutionize
disease
diagnosis
treatment.
