Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2045 - 2045

Опубликована: Янв. 20, 2023

In this review, we discuss sympathetic regulation in normal and diabetic wound healing. Experimental denervation studies have confirmed that nerve endings skin an important complex role Vasoconstrictor neurons secrete norepinephrine (NE) neuropeptide Y (NPY). Both mediators decrease blood flow interact with inflammatory cells keratinocytes. NE acts ambiguous way depending on receptor type. Beta2-adrenoceptors could be activated near endings; they suppress inflammation re-epithelialization. Alpha1- alpha2-adrenoceptors induce activate Sudomotor acetylcholine (ACh) vasoactive intestinal peptide (VIP). vasodilatation, angiogenesis, inflammation, keratinocytes proliferation migration. healthy skin, all effects are for successful treatment of ulcers, mediator balance shifted different ways. blockade nicotinic ACh receptors activation the most promising directions ulcers neuropathy, but require further research.

Язык: Английский

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Local analgesia of electroacupuncture is mediated by the recruitment of neutrophils and released β-endorphins

Pain, Год журнала: 2023, Номер 164(9), С. 1965 - 1975

Опубликована: Апрель 7, 2023

Abstract The efficacy of acupuncture in treating pain diseases has been recognized clinical practice, and its mechanism action a hot topic academic research. Previous basic research on analgesia focused mostly the nervous system, with few studies addressing immune system as potential pathway analgesia. In this study, we investigated effect electroacupuncture (EA) β-endorphins (β-END) content, END-containing leukocyte type number, sympathetic neurotransmitter norepinephrine (NE), chemokine gene expression inflamed tissues. To induce inflammatory pain, about 200 µL complete Frester adjuvant (CFA) was injected into unilateral medial femoral muscle adult Wistar rats. Electroacupuncture treatment performed for 3 days beginning day 4 after CFA injection, parameters 2/100 Hz, 2 mA, 30 minutes per treatment. weight-bearing experiment enzyme-linked immunosorbent assay showed that EA significantly relieved spontaneous pain-like behaviors increased level β-END tissue. Injection anti-END antibody tissue blocked analgesic effect. Flow cytometry immunofluorescence staining revealed EA-induced increase derived from opioid-containing ICAM-1 + /CD11b cells addition, NE content β2 adrenergic receptor (ADR-β2) tissues upregulated Cxcl1 Cxcl6 levels. These findings provide new evidence peripheral by recruiting β-END–containing increasing at site inflammation.

Язык: Английский

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Aging and “Age-Related” Diseases - What Is the Relation?

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

The study explores the intricate relationship between aging and development of noncommunicable diseases [NCDs], focusing on whether these are inevitable consequences or primarily driven by lifestyle factors. By examining epidemiological data, particularly from hunter-gatherer societies, highlights that many NCDs prevalent in modern populations rare suggesting a significant influence choices. It delves into mechanisms through which poor diet, smoking, other factors contribute to systemic physiological imbalances, characterized oxidative stress, insulin resistance hyperinsulinemia, dysregulation sympathetic nervous system, renin-angiotensin-aldosterone immune system. interplay this pattern individual such as genetic susceptibility, biological variability, epigenetic changes microbiome is proposed play crucial role range age-related NCDs. Modified biomolecules oxysterols advanced glycation end products also their development. Specific benign prostatic hyperplasia, Parkinson's disease, glaucoma osteoarthritis analyzed illustrate mechanisms. concludes while contributes risk NCDs, role, offering potential avenues for prevention intervention healthier living practices. One possible approach could be try restore balance, e.g. dietary measures [e.g. Mediterranean Okinawan diet Paleolithic diet] conjunction with [a combination of] pharmacological interventions changes.

Язык: Английский

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Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward

Journal for ImmunoTherapy of Cancer, Год журнала: 2021, Номер 9(10), С. e003013 - e003013

Опубликована: Окт. 1, 2021

Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex networks orchestrated by several most potent immunosuppressive metabolites, highlighting impact adenosine, kynurenines, prostaglandin E2, norepinephrine epinephrine, while discussing completed ongoing clinical efforts to curtail their impact. Retrospective analyses data have elucidated activity is negatively associated with prognosis in diverse cancer indications, though there current paucity approved therapies disrupt synthesis or downstream signaling axes. hypothesize prior lukewarm results may be attributed redundancies each metabolites' pathway highlight routes for how therapeutic development patient stratification might proceed future.

Язык: Английский

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Dopamine and norepinephrine are embracing their immune side and so should we

Current Opinion in Neurobiology, Год журнала: 2022, Номер 77, С. 102626 - 102626

Опубликована: Сен. 1, 2022

Язык: Английский

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Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Апрель 7, 2022

Despite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There renewed attention on peripheral inflammatory signaling as way modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been focus for understanding mechanisms sickness behavior, which an adaptive autonomic, neuroendocrine, behavioral response to inflammation. It mediated by humoral neural pathways that mainly involve circumventricular organs vagal nerve, respectively. In this review we address question how sepsis can dysregulate response, notably impairing central integration signaling, but also efferent control immune response. We highlight potential role gut–brain brain–spleen in stroke.

Язык: Английский

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Menstrual disturbances following COVID-19 vaccination: A probable puzzle about the role of endocrine and immune pathways

Journal of Reproductive Immunology, Год журнала: 2023, Номер 158, С. 103952 - 103952

Опубликована: Май 12, 2023

Язык: Английский

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Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июнь 25, 2024

Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.

Язык: Английский

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The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?

Brain Behavior and Immunity, Год журнала: 2021, Номер 94, С. 381 - 391

Опубликована: Март 2, 2021

Язык: Английский

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Prognostic Neurotransmitter Receptors Genes Are Associated with Immune Response, Inflammation and Cancer Hallmarks in Brain Tumors

Cancers, Год журнала: 2022, Номер 14(10), С. 2544 - 2544

Опубликована: Май 21, 2022

Glioblastoma multiforme (GBM) is one of the most aggressive forms cancer. Neurotransmitters (NTs) have recently been linked with uncontrolled proliferation cancer cells, but role NTs in progression human gliomas still largely unexplored. Here, we investigate genes encoding for neurotransmitter receptors (NTRs) by analyzing public transcriptomic data from GBM and LGG (low-grade glioma) samples. Our results showed that 50 out 98 tested NTR were dysregulated brain tissue. Next, identified validated NTR-associated prognostic gene signatures both GBM. A subset 10 (DRD1, HTR1E, HTR3B, GABRA1, GABRA4, GABRB2, GABRG2, GRIN1, GRM7, ADRA1B) predicted a positive prognosis negative These progressively downregulated across glioma grades exhibited strong correlation associated immune response, inflammasomes, established hallmarks lower grade gliomas, suggesting putative inhibiting progression. This study might implications development novel therapeutics preventive strategies target regulatory networks link between autonomic nervous system, tumor microenvironment.

Язык: Английский

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