Journal of cardiovascular computed tomography, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
JACC. Cardiovascular imaging, Год журнала: 2022, Номер 15(6), С. 1078 - 1088
Опубликована: Апрель 13, 2022
Язык: Английский
Процитировано
106
Nature Reviews Cardiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
3
Atherosclerosis, Год журнала: 2021, Номер 321, С. 30 - 38
Опубликована: Фев. 16, 2021
Язык: Английский
Процитировано
89
Cardiovascular Research, Год журнала: 2021, Номер unknown
Опубликована: Авг. 27, 2021
Abstract Aims Coronary computed tomography angiography (CCTA) is a first-line modality in the investigation of suspected coronary artery disease (CAD). Mapping perivascular fat attenuation index (FAI) on routine CCTA enables non-invasive detection inflammation by quantifying spatial changes composition. We now report performance new medical device, CaRi-Heart®, which integrates standardized FAI mapping together with clinical risk factors and plaque metrics to provide individualized cardiovascular prediction. Methods results The study included 3912 consecutive patients undergoing as part care USA (n = 2040) Europe 1872). These cohorts were used generate age-specific nomograms percentile curves reference maps for interpretation FAI. first output CaRi-Heart® FAI-Score each artery, provides measure adjusted technical, biological, anatomical characteristics. then incorporated into prediction algorithm CCTA-derived Risk that predicts likelihood fatal cardiac event at 8 years. was trained US population its validated externally European population. It improved discrimination over factor-based model [Δ(C-statistic) 0.085, P 0.01 Cohort 0.149, < 0.001 cohort] had consistent net benefit decision curve analysis above baseline traditional across spectrum risk. Conclusion allows measurement calculating artery. device reliable patient's absolute incorporating along comprehensive adipose tissue phenotyping. This integration advances prognostic utility individual paves way use dual diagnostic tool among referred CCTA.
Язык: Английский
Процитировано
76
Cardiovascular Diabetology, Год журнала: 2022, Номер 21(1)
Опубликована: Март 18, 2022
Abstract Background Pericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CTA) is a non-invasive biomarker for pericoronary inflammation. We aimed to investigate the prognostic value of PCAT in patients with type 2 diabetes mellitus (T2DM). Methods included 333 T2DM (mean age, 66 years; male patients, 211; mean body mass index, 25 kg/m ) who underwent clinically indicated CTA and examined their CT findings, artery calcium score, pericardial fat volume, stenosis (> 50% luminal narrowing), high-risk plaque features low-attenuation and/or positive remodelling spotty calcification, attenuation. assessed Hounsfield units (HU) proximal 40-mm segments left anterior descending (LAD) right (RCA). Cardiovascular events were defined as cardiac death, hospitalisation acute syndrome, late revascularisation, heart failure. Results During median follow-up 4.0 years, we observed 31 cardiovascular events. LAD-PCAT was significantly higher than those without (− 68.5 ± 6.5 HU vs − 70.8 6.1 HU, p = 0.045), whereas RCA-PCAT not (p 0.089). High 70.7 HU; value) associated model that adverse such significant (hazard ratio; 2.69, 95% confidence interval; 1.17–0.20, 0.020). After adding C-statistic global chi-square values increased from 0.65 0.70 0.037) 10.9–15.0 0.043), respectively. Conclusions In undergoing CTA, high could predict This suggests assessing can help physicians identify patients.
Язык: Английский
Процитировано
48
Journal of the American College of Cardiology, Год журнала: 2023, Номер 81(9), С. 913 - 923
Опубликована: Фев. 27, 2023
Язык: Английский
Процитировано
34
European Heart Journal - Cardiovascular Imaging, Год журнала: 2024, Номер 25(10), С. 1351 - 1359
Опубликована: Авг. 6, 2024
Abstract Aims Pericoronary adipose tissue (PCAT) attenuation obtained by coronary computed tomography angiography (CCTA) has been associated with inflammation and outcomes. Whether PCAT is predictive of major adverse cardiac events (MACE) during long-term follow-up unknown. Methods results Symptomatic patients artery disease (CAD) who underwent CCTA were included, clinical outcomes evaluated. was measured at all lesions for three arteries using semi-automated software. A comparison between without MACE made on both a per-lesion per-patient level. The value assessed in Cox regression models. In 483 (63.3 ± 8.5 years, 54.9% men), 1561 analysed over median duration 9.5 years. mean not significantly different MACE. At level, the adjusted hazard ratio (HR) 95% confidence interval (CI) 0.970 (95% CI: 0.933–1.008, P = 0.121) when average per patient analysed, 0.992 0.961–1.024, 0.622) only most obstructive lesion evaluated, 0.981 0.946–1.016, 0.285) highest individual Adjusted HRs vessel-specific right artery, left anterior descending circumflex 0.957 0.830–1.104, 0.548), 0.989 0.954–1.025, 0.550), 0.739 0.293–1.865, 0.522), respectively, predicting Conclusion referred to clinically suspected CAD, did predict follow-up.
Язык: Английский
Процитировано
11
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Фев. 24, 2024
Abstract Background Insulin resistance (IR) is associated with coronary artery disease (CAD) severity. However, its underlying mechanisms are not fully understood. Therefore, our study aimed to explore the relationship between IR and inflammation investigate synergistic mediating effects of on association CAD Methods Consecutive patients who underwent angiography computed tomography April 2018 March 2023 were enrolled. The triglyceride–glucose index (TyG index) peri-coronary adipose tissue (PCAT) attenuation around proximal right (RCA) used evaluate inflammation, respectively. correlation TyG PCAT was analyzed using linear regression models. Logistic models further for investigating A mediation analysis assessed severity mediated by inflammation. Results total 569 participants (mean age, 62 ± 11 years; 67.8% men) included in study. positively ( r = 0.166; P < 0.001). After adjusting potential confounders, per standard deviation increment a 1.791 Hounsfield unit (HU) increase (95% confidence interval [CI], 0.920–2.662 HU; 0.001) attenuation. In total, 382 (67.1%) had multivessel CAD. high-TyG index/high group approximately 3.2 times odds compared those low-TyG index/low (odds ratio, 3.199; 95%CI, 1.826–5.607; Mediation indicated that 31.66% Conclusions correlated showed Furthermore, partially Controlling high may provide additional benefits.
Язык: Английский
Процитировано
10
European Radiology, Год журнала: 2021, Номер 31(10), С. 7251 - 7261
Опубликована: Апрель 16, 2021
To investigate the association of pericoronary adipose tissue mean attenuation (PCATMA) with coronary artery disease (CAD) characteristics on computed tomography angiography (CCTA).We retrospectively investigated 165 symptomatic patients who underwent third-generation dual-source CCTA at 70kVp: 93 and 72 without CAD (204 arteries plaque, 291 plaque). was evaluated for presence per artery. PCATMA measured proximally across most severe stenosis. Patient-level, proximal defined as three main arteries. Analyses were performed patient vessel level.Mean -96.2 ± 7.1 HU -95.6 7.8HU (p = 0.644). In lesion-specific similar (-96.1 9.6 HU, -95.9 11.2 p 0.608). Lesion-specific plaque (-94.7 HU) differed from (-97.2 0.015). Minimal stenosis showed higher (-94.0 than (-98.5 0.030). non-calcified, mixed, calcified -96.5 -94.6 -89.9 0.004). Vessel-based total lipid-rich necrotic core, burden a very weak to moderate correlation PCATMA.Lesion-specific in plaque. non-calcified mixed plaques compared plaques, minimal severe; did not show these relationships. This suggests that is related development vulnerability.• undergoing 70 kVp, those • contrast measurement vessels, clear relationships degree.
Язык: Английский
Процитировано
44
British Journal of Radiology, Год журнала: 2023, Номер 96(1145)
Опубликована: Янв. 6, 2023
Pericoronary adipose tissue (PCAT) is the fat deposit surrounding coronary arteries. Although PCAT part of larger epicardial (EAT) depot, it has different pathophysiological features and roles in atherosclerosis process. While EAT evaluation been studied for years, a relatively new concept. PCAT, especially mean attenuation derived from CT images may be used to evaluate inflammatory status arteries non-invasively. The most commonly measure, PCATMA, 3 mm thickness around proximal right artery with length 40 mm. PCATMA can analyzed on per-lesion, per-vessel or per-patient basis. Apart other measures have studied, such as thickness, volume. Studies shown associations between anatomical functional severity disease. associated plaque components high-risk features, discriminate patients flow obstructing stenosis myocardial infarction. Whether value an individual patient basis remains determined. Furthermore, imaging settings, kV levels clinical factors age sex affect measurements, which complicate implementation practice. For widely implemented, standardized methodology needed. This review gives overview reported methodologies current literature potential use cases
Язык: Английский
Процитировано
21