Journal of Computer Assisted Tomography,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Objective:
Vascular
inflammation
affects
acute
coronary
syndrome
(ACS)
occurrence
in
patients
with
stable
angina.
Coronary
can
be
represented
by
the
pericoronary
fat
attenuation
index
(FAI).
This
study
investigated
quantitative
prognostic
value
of
plaque
characteristics
and
FAI
Methods:
Risk
factors
for
ACS
angina
pectoris
were
retrospectively
analyzed.
The
diagnostic
these
determined;
Kaplan-Meier
curves
used
to
predict
event
incidence.
Results:
After
postpropensity
score
matching,
data
60
130
without
ACS,
respectively,
Pericoronary
FAI,
lipid
volume,
percentage
narrowest
segment
significantly
improved
diagnosis
Luminal
stenosis
≥50%
>−88
Hounsfield
units
(HU)
independent
risk
Perileft
anterior
descending
artery
(LAD)
HU
better
predicted
than
did
peri-LAD
≤−88
HU.
Conclusions:
In
angina,
volume
ability
luminal
occurrence.
Furthermore,
could
Cardiovascular Research,
Journal Year:
2021,
Volume and Issue:
unknown
Published: Aug. 27, 2021
Abstract
Aims
Coronary
computed
tomography
angiography
(CCTA)
is
a
first-line
modality
in
the
investigation
of
suspected
coronary
artery
disease
(CAD).
Mapping
perivascular
fat
attenuation
index
(FAI)
on
routine
CCTA
enables
non-invasive
detection
inflammation
by
quantifying
spatial
changes
composition.
We
now
report
performance
new
medical
device,
CaRi-Heart®,
which
integrates
standardized
FAI
mapping
together
with
clinical
risk
factors
and
plaque
metrics
to
provide
individualized
cardiovascular
prediction.
Methods
results
The
study
included
3912
consecutive
patients
undergoing
as
part
care
USA
(n
=
2040)
Europe
1872).
These
cohorts
were
used
generate
age-specific
nomograms
percentile
curves
reference
maps
for
interpretation
FAI.
first
output
CaRi-Heart®
FAI-Score
each
artery,
provides
measure
adjusted
technical,
biological,
anatomical
characteristics.
then
incorporated
into
prediction
algorithm
CCTA-derived
Risk
that
predicts
likelihood
fatal
cardiac
event
at
8
years.
was
trained
US
population
its
validated
externally
European
population.
It
improved
discrimination
over
factor-based
model
[Δ(C-statistic)
0.085,
P
0.01
Cohort
0.149,
<
0.001
cohort]
had
consistent
net
benefit
decision
curve
analysis
above
baseline
traditional
across
spectrum
risk.
Conclusion
allows
measurement
calculating
artery.
device
reliable
patient's
absolute
incorporating
along
comprehensive
adipose
tissue
phenotyping.
This
integration
advances
prognostic
utility
individual
paves
way
use
dual
diagnostic
tool
among
referred
CCTA.
Cardiovascular Diabetology,
Journal Year:
2022,
Volume and Issue:
21(1)
Published: March 18, 2022
Abstract
Background
Pericoronary
adipose
tissue
(PCAT)
attenuation
on
coronary
computed
tomography
angiography
(CTA)
is
a
non-invasive
biomarker
for
pericoronary
inflammation.
We
aimed
to
investigate
the
prognostic
value
of
PCAT
in
patients
with
type
2
diabetes
mellitus
(T2DM).
Methods
included
333
T2DM
(mean
age,
66
years;
male
patients,
211;
mean
body
mass
index,
25
kg/m
)
who
underwent
clinically
indicated
CTA
and
examined
their
CT
findings,
artery
calcium
score,
pericardial
fat
volume,
stenosis
(>
50%
luminal
narrowing),
high-risk
plaque
features
low-attenuation
and/or
positive
remodelling
spotty
calcification,
attenuation.
assessed
Hounsfield
units
(HU)
proximal
40-mm
segments
left
anterior
descending
(LAD)
right
(RCA).
Cardiovascular
events
were
defined
as
cardiac
death,
hospitalisation
acute
syndrome,
late
revascularisation,
heart
failure.
Results
During
median
follow-up
4.0
years,
we
observed
31
cardiovascular
events.
LAD-PCAT
was
significantly
higher
than
those
without
(−
68.5
±
6.5
HU
vs
−
70.8
6.1
HU,
p
=
0.045),
whereas
RCA-PCAT
not
(p
0.089).
High
70.7
HU;
value)
associated
model
that
adverse
such
significant
(hazard
ratio;
2.69,
95%
confidence
interval;
1.17–0.20,
0.020).
After
adding
C-statistic
global
chi-square
values
increased
from
0.65
0.70
0.037)
10.9–15.0
0.043),
respectively.
Conclusions
In
undergoing
CTA,
high
could
predict
This
suggests
assessing
can
help
physicians
identify
patients.
Cardiovascular Diabetology,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Feb. 24, 2024
Abstract
Background
Insulin
resistance
(IR)
is
associated
with
coronary
artery
disease
(CAD)
severity.
However,
its
underlying
mechanisms
are
not
fully
understood.
Therefore,
our
study
aimed
to
explore
the
relationship
between
IR
and
inflammation
investigate
synergistic
mediating
effects
of
on
association
CAD
Methods
Consecutive
patients
who
underwent
angiography
computed
tomography
April
2018
March
2023
were
enrolled.
The
triglyceride–glucose
index
(TyG
index)
peri-coronary
adipose
tissue
(PCAT)
attenuation
around
proximal
right
(RCA)
used
evaluate
inflammation,
respectively.
correlation
TyG
PCAT
was
analyzed
using
linear
regression
models.
Logistic
models
further
for
investigating
A
mediation
analysis
assessed
severity
mediated
by
inflammation.
Results
total
569
participants
(mean
age,
62
±
11
years;
67.8%
men)
included
in
study.
positively
(
r
=
0.166;
P
<
0.001).
After
adjusting
potential
confounders,
per
standard
deviation
increment
a
1.791
Hounsfield
unit
(HU)
increase
(95%
confidence
interval
[CI],
0.920–2.662
HU;
0.001)
attenuation.
In
total,
382
(67.1%)
had
multivessel
CAD.
high-TyG
index/high
group
approximately
3.2
times
odds
compared
those
low-TyG
index/low
(odds
ratio,
3.199;
95%CI,
1.826–5.607;
Mediation
indicated
that
31.66%
Conclusions
correlated
showed
Furthermore,
partially
Controlling
high
may
provide
additional
benefits.
European Heart Journal - Cardiovascular Imaging,
Journal Year:
2024,
Volume and Issue:
25(10), P. 1351 - 1359
Published: Aug. 6, 2024
Abstract
Aims
Pericoronary
adipose
tissue
(PCAT)
attenuation
obtained
by
coronary
computed
tomography
angiography
(CCTA)
has
been
associated
with
inflammation
and
outcomes.
Whether
PCAT
is
predictive
of
major
adverse
cardiac
events
(MACE)
during
long-term
follow-up
unknown.
Methods
results
Symptomatic
patients
artery
disease
(CAD)
who
underwent
CCTA
were
included,
clinical
outcomes
evaluated.
was
measured
at
all
lesions
for
three
arteries
using
semi-automated
software.
A
comparison
between
without
MACE
made
on
both
a
per-lesion
per-patient
level.
The
value
assessed
in
Cox
regression
models.
In
483
(63.3
±
8.5
years,
54.9%
men),
1561
analysed
over
median
duration
9.5
years.
mean
not
significantly
different
MACE.
At
level,
the
adjusted
hazard
ratio
(HR)
95%
confidence
interval
(CI)
0.970
(95%
CI:
0.933–1.008,
P
=
0.121)
when
average
per
patient
analysed,
0.992
0.961–1.024,
0.622)
only
most
obstructive
lesion
evaluated,
0.981
0.946–1.016,
0.285)
highest
individual
Adjusted
HRs
vessel-specific
right
artery,
left
anterior
descending
circumflex
0.957
0.830–1.104,
0.548),
0.989
0.954–1.025,
0.550),
0.739
0.293–1.865,
0.522),
respectively,
predicting
Conclusion
referred
to
clinically
suspected
CAD,
did
predict
follow-up.
American Journal of Roentgenology,
Journal Year:
2024,
Volume and Issue:
223(5)
Published: Aug. 21, 2024
Background:
Pericoronary
adipose
tissue
(PCAT)
attenuation
and
fat
index
(FAI)
may
serve
as
markers
of
inflammation
risk
adverse
cardiac
events.
However,
standardization
relevant
CT
acquisition
reconstruction
parameters
is
lacking.
