Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 14, 2025
Gender-
and
sex-based
disparities
in
response
to
immune-checkpoint
inhibitors
(ICI)
has
been
reported
a
variety
of
tumor
types.
Women
have
different
anatomy
with
recurrent
urinary
tract
infections,
sex
hormonal
profile,
intrinsic
differences
local
systemic
immune
systems
urobiome
composition.
Existing
literature
data
pan-cancer
context
reveal
contradictory
results,
real-world
evidence
urothelial
carcinoma
(UC)
is
lacking.
This
was
real-world,
multicenter,
international,
observational
study
determine
the
effects
on
clinical
outcomes
metastatic
(mUC)
patients
progressing
or
recurring
after
platinum-based
therapy
treated
pembrolizumab
as
part
routine
care.
A
total
1039
patients,
from
January
1st,
2016
December
31st,
2023
68
cancer
centers
were
included.
Our
showed
that
women
had
shorter
OS
than
men,
13%
advantage
5-year
rate
for
male
patients.
deeper
understanding
these
results
may
inform
sex-stratification
future
prospective
trials
help
develop
strategies
reduce
magnitude
observed
outcomes.
Aktuelle Urologie,
Год журнала:
2025,
Номер
56(02), С. 158 - 163
Опубликована: Апрель 1, 2025
Zusammenfassung
Geschlechtsunterschiede
in
der
Medizin
spielen
mittlerweile
eine
nicht
mehr
wegzudenkende
Rolle,
sowohl
Diagnostik
als
auch
Therapie.
Risikofaktoren
und
Mortalität
variieren
je
nach
Geschlecht,
Krankheiten
äußern
sich
unterschiedlich.
In
müssen
Geschlecht
unterschiedliche
Aspekte
Betracht
gezogen
werden.
Bei
Blasenkarzinomen
zum
Beispiel
kommt
es
bei
Frauen
häufig
zu
Verzögerungen
Diagnose,
weil
Hämaturie
oft
benignen
Erkrankungen
wie
Harnwegsinfekten
zugeschrieben
wird.
Therapieentscheidungen
sollte
das
ebenso
Rolle
spielen.
Um
ein
nennen,
haben
Immuncheckpoint-Inhibitoren
Nierenzellkarzinomen
Männern
besseres
Ansprechen
Frauen.
Auch
die
Outcomes
onkologischer
Therapie
urologischen
Tumoren
Geschlecht.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 28, 2024
Across
the
wide
range
of
clinical
conditions,
there
exists
a
sex
imbalance
where
biological
females
are
more
prone
to
autoimmune
diseases
and
males
some
cancers.
These
discrepancies
combinatory
consequence
lifestyle
environmental
factors
such
as
smoking,
alcohol
consumption,
obesity,
oncogenic
viruses,
well
other
intrinsic
traits
including
chromosomes
hormones.
While
emergence
immuno-oncology
(I/O)
has
revolutionised
cancer
care,
efficacy
across
multiple
cancers
may
be
limited
because
complex,
dynamic
interplay
between
tumour
its
microenvironment
(TME).
Indeed,
gender
can
also
influence
varying
effectiveness
I/O.
Androgen
receptor
(AR)
plays
an
important
role
in
tumorigenesis
shaping
TME.
Here,
we
lay
out
epidemiological
context
disparity
then
review
current
literature
on
how
AR
signalling
contributes
observation
via
altered
development
immunology.
We
offer
insights
into
AR-mediated
immunosuppressive
mechanisms,
with
hope
translating
preclinical
evidence
oncology
improved
outcomes
personalised,
I/O-based
care.
Cancer Immunology Immunotherapy,
Год журнала:
2024,
Номер
73(8)
Опубликована: Июнь 4, 2024
Abstract
Background
There
is
an
ongoing
debate
as
to
whether
sex
could
be
associated
with
immune
checkpoint
inhibitor
(ICI)
benefit.
Existing
literature
data
reveal
contradictory
results,
and
on
first-line
combinations
are
lacking.
Method
This
was
a
real-world,
multicenter,
international,
observational
study
determine
the
effects
clinical
outcomes
in
metastatic
renal
cell
carcinoma
(mRCC)
patients
treated
immuno-oncology
therapy.
Results
A
total
of
1827
mRCC
from
71
cancer
centers
21
countries
were
included.
The
median
OS
38.7
months
(95%
CI
32.7–44.2)
overall
population:
40.0
32.7–51.6)
males
26.4–41.0)
females
(
p
=
0.202).
higher
vs.
aged
18-49y
(36.9
months,
95%
29.0–51.6,
24.8
16.8–40.4,
0.426,
+
19%
2y-OS
rate,
72%
53%,
0.006),
clear
histology
subgroup
(44.2
35.8–55.7,
26.0–41.0,
0.047),
sarcomatoid
differentiation
(34.4
26.4–59.0,
15.3
8.9–41.0,
<
0.001).
Sex
female
independent
negative
prognostic
factor
population
(HR
1.72,
1.15
−
2.57,
0.008).
Conclusions
Although
female’s
innate
adaptive
immunity
has
been
observed
more
active
than
male’s,
women
histology,
differentiation,
those
under
50
years
age
showed
shorter
males.
Immunotherapy,
Год журнала:
2023,
Номер
15(15), С. 1309 - 1322
Опубликована: Сен. 11, 2023
Aim:
To
compare
the
efficacy
of
first-line
immune
checkpoint
inhibitor
(ICI)-based
combinations
in
metastatic
renal
cell
carcinoma
(mRCC)
patients
stratified
by
chronological
age.
Methods:
According
to
Preferred
Reporting
Items
for
Systematic
Reviews
and
Meta-Analyses
(PRISMA)
guidelines,
hazard
ratios
overall
survival
(OS)
from
randomized
controlled
trials
were
synthesized.
Results:
Five
RCTs
eligible
meta-analyses.
ICI-based
significantly
improved
OS
compared
with
sunitinib
alone,
both
younger
(<65
years)
older
(≥65
patients,
whereas
benefit
was
better
(p
=
0.007).
did
not
improve
aged
≥75
years.
Treatment
rankings
showed
age-related
differential
recommendations
regarding
OS.
Conclusion:
greater
patients.
Age-related
differences
could
help
enrich
shared
decision-making.Scientists
have
found
a
special
way
treat
type
cancer
called
carcinoma.
They
use
combination
medicines
that
body's
system
fight
cancer.
These
treatments
are
very
effective
recommended
as
first
choice
this
However,
people
get
older,
their
systems
may
work
well.
Studies
looking
at
how
these
different
age
groups,
it
discovered
chances
all
no
matter
they
also
noticed
got
even
more
benefits
treatments.
Because
discoveries,
doctors
can
now
make
decisions
about
which
treatment
cancer,
depending
on
patient
Therapeutic Advances in Medical Oncology,
Год журнала:
2024,
Номер
16
Опубликована: Янв. 1, 2024
Kidney
cancer
is
a
common
malignancy
that
constitutes
around
5%
of
all
cases.
Males
are
twice
as
likely
to
acquire
renal
cell
carcinoma
(RCC)
compared
females
and
experience
higher
rate
mortality.
These
disparities
indicate
sex
hormone
(SH)-dependent
pathways
may
have
an
impact
on
the
aetiology
pathophysiology
RCC.
Examination
SH
involvement
in
conventional
signalling
pathways,
well
genetics
genomics,
especially
ribonucleic
acid,
reveal
further
insights
into
sex-related
differences.
An
understanding
SHs
their
influence
kidney
essential
offer
patients
individualized
medicine
would
better
meet
needs
terms
prevention,
diagnosis
treatment.
This
review
presents
differences
clinical
manifestation
underlying
biological
processes.
