Polyphenols and Human Health: The Role of Bioavailability

Nutrients, Год журнала: 2021, Номер 13(1), С. 273 - 273

Опубликована: Янв. 19, 2021

Polyphenols are a group of phytochemicals with potential health-promoting effects. They classified as flavonoid (flavonols, flavanols, flavones, flavanones, isoflavones, and anthocyanins) non-flavonoid molecules (phenolic acids, hydroxycinnamic lignans, stilbenes, tannins). Although an increasing number trials have shown correlation among polyphenol consumption reduction in risk factors for chronic diseases, discrepancies explaining their positive effects been found terms the bioavailability. In fact, polyphenols show low bioavailability due to several factors: interaction food matrix, metabolic processes mediated by liver (phase I II metabolism), intestine microbiota. On other hand, biological activities phenol compounds may be metabolites, which produced vivo, recent studies confirmed that these antioxidant anti-phlogistic properties. This review discusses performed consider different sources. Factors influencing main classes also considered.

Язык: Английский

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Concept, mechanism, and applications of phenolic antioxidants in foods

Journal of Food Biochemistry, Год журнала: 2020, Номер 44(9)

Опубликована: Июль 20, 2020

In this review, the concept of phenolic antioxidants, mechanisms action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety free radicals. The mechanism actions involved either hydrogen atom transfer, transfer single electron, sequential proton loss electron chelation transition metals. foods, PCs act antioxidants which are measured several in vitro spectroscopic methods. found milk wide range dairy products sole purposes color, taste, storage stability, quality enhancement. role three types food additives, that is, antimicrobial, antioxidant, flavoring agents critically literature revealed present foods possess health benefits such antibacterial, antihyperlipidemic, anticancer, cardioprotective, neuroprotective, antidiabetic properties. Practical strong safer than synthetic antioxidants. occurrence plant warranted continuous review applications. This therefore, presented updated comprehensive overview concept, mechanism, foods.

Язык: Английский

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Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics

Nutrients, Год журнала: 2021, Номер 14(1), С. 137 - 137

Опубликована: Дек. 28, 2021

The present review summarizes the studies carried out on this topic in last five years. According to new definitions, among all compounds included group of prebiotics, polyphenols are probably most important secondary metabolites produced by plant kingdom. Many these types have low bioavailability, therefore reaching colon unaltered form. Once colon, interact with intestinal microbes bidirectionally modulating them and, consequently, releasing metabolites. Despite much research various metabolites, little is known about chemistry metabolic routes used different bacteria species. In context, aims investigate prebiotic effect preclinical and clinical studies, highlighting that consumption leads an increase beneficial bacteria, as well production valuable conclusion, there evidence supporting polyphenols, but further needed humans.

Язык: Английский

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p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects

Antioxidants, Год журнала: 2019, Номер 8(8), С. 275 - 275

Опубликована: Авг. 4, 2019

Controlling unwanted hyperpigmentation is a major challenge in dermatology and cosmetology, safe efficacious antimelanogenic agents are deemed useful for this purpose. p-Coumaric acid natural metabolite contained many edible plants, its antioxidant activities reducing oxidative stress inflammatory reactions have been demonstrated various experimental models. has the optimal structure to be competitive inhibitor of tyrosinase that catalyzes key melanin biosynthetic pathway. Experimental evidence supports notion as it was found more potent tyrosinase, especially toward human enzymes, than other well-known inhibitors such arbutin kojic acid. inhibited synthesis murine melanoma cells, epidermal melanocytes, reconstituted three-dimensional skin Ex-vivo permeation experiments in-vivo efficacy tests p-coumaric confirmed efficient transdermal delivery functional erythema development pigmentation due ultraviolet radiation exposure. Human studies further supported effectiveness hypopigmentation depigmentation. These findings suggest good potential used skin-lightening active ingredient cosmetics. Future needed extensively examine safety develop an optimized cosmetic formulation best performance lightening.

Язык: Английский

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Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Foods, Год журнала: 2020, Номер 9(4), С. 534 - 534

Опубликована: Апрель 24, 2020

Nature has generously offered a wide range of herbs (e.g., thyme, oregano, rosemary, sage, mint, basil) rich in many polyphenols and other phenolic compounds with strong antioxidant biochemical properties. This paper focuses on several natural occurring acids (caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) first gives an overview their most common plant sources. A summary the recently reported activities o/w emulsions is also provided as vitro lipid-based model system. Exploring interfacial activity could help to further elucidate potential health properties against oxidative stress conditions biological membranes (such lipoproteins). Finally, this review reports latest literature evidence concerning specific examined acids.

Язык: Английский

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Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

Nutrients, Год журнала: 2020, Номер 12(8), С. 2190 - 2190

Опубликована: Июль 23, 2020

Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged food products rich HCAs; however, processing, dietary intake, bioaccessibility pharmacokinetics a impact on HCAs to reach the target tissue order exert their biological activities. In particular, metabolism is of importance since HCAs’ metabolites could either lose activity or be even more potent compared parent compounds. this review, sources pharmacokinetic properties esters presented discussed. The main focus along with activities benefits. Special emphasis given specific comparison

Язык: Английский

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Exploring the potential of antioxidants from fruits and vegetables and strategies for their recovery

Innovative Food Science & Emerging Technologies, Год журнала: 2022, Номер 77, С. 102974 - 102974

Опубликована: Март 4, 2022

A balanced and nutritious diet is the cornerstone of good health. The nutritional pyramid advises eating 5 servings fruit vegetables a day as basic principle healthy diet, they provide essential nutrients such vitamins minerals, well fiber antioxidants. Consuming them in adequate quantities improves immune system helps prevent diseases diabetes, obesity, heart disease even certain types cancer. Among most nutrient-dense are This context for this review, which an exhaustive analysis has been carried out bioactive compounds with antioxidant capacity available widely produced Spain, considering not only studies that identify these compounds, but also those analyze their effects on human Furthermore, it worth highlighting interest extraction by-product streams from vegetable processing circular economy. Therefore, review includes examples green technologies antioxidants waste fractions. In field, microwave ultrasound-assisted have found to be efficient, both terms yields, similar conventional technologies, operating conditions required process. However, enzyme cocktails or pulsed electric fields show promising results.

Язык: Английский

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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 171, С. 289 - 331

Опубликована: Фев. 18, 2021

Although oral drug delivery is the preferred administration route and has been used for centuries, modern discovery development pipelines challenge conventional formulation approaches highlight insufficient mechanistic understanding of processes critical to absorption. This review presents opinion UNGAP scientists on four key themes across absorption landscape: (1) specific patient populations, (2) regional differences in gastrointestinal tract, (3) advanced formulations (4) food-drug interactions. The pediatric geriatric issues colonic absorption, poorly water-soluble (small molecules) permeable (peptides, RNA etc.) drugs, as well vast realm food effects, are some topics discussed detail. identified controversies gaps current absorption-related create a roadmap future research.

Язык: Английский

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Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies

Redox Biology, Год журнала: 2024, Номер 71, С. 103095 - 103095

Опубликована: Фев. 20, 2024

This systematic review provides an overview of the available evidence on inter-individual variability (IIV) in absorption, distribution, metabolism, and excretion (ADME) phenolic metabolites its determinants. Human studies were included investigating metabolism bioavailability (poly)phenols reporting IIV. One hundred fifty-three met inclusion criteria. Inter-individual differences mainly related to gut microbiota composition activity but also genetic polymorphisms, age, sex, ethnicity, BMI, (patho)physiological status, physical activity, depending (poly)phenol sub-class considered. Most IIV has been poorly characterised. Two major types observed. resulted metabolite gradients that can be further classified into high low excretors, as seen for all flavonoids, acids, prenylflavonoids, alkylresorcinols, hydroxytyrosol. The other type is based clusters individuals defined by qualitative (producers vs. non-producers), ellagitannins (urolithins), isoflavones (equol O-DMA), resveratrol (lunularin), preliminarily avenanthramides (dihydro-avenanthramides), or quali-quantitative metabotypes characterized different proportions specific metabolites, flavan-3-ols, flavanones, even isoflavones. Future works are needed shed light current open issues limiting our understanding this phenomenon likely conditions health effects dietary (poly)phenols.

Язык: Английский

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Natural Antioxidants: Advancing Stability and Performance in Sustainable Biobased and Biodegradable Plastics

Compounds, Год журнала: 2025, Номер 5(1), С. 4 - 4

Опубликована: Фев. 3, 2025

The depletion of fossil fuels and environmental concerns have driven the development sustainable materials, including bio-based biodegradable plastics, as alternatives to conventional plastics. Although these plastics aid in waste management climate change mitigation, their vulnerability oxidative degradation impacts longevity, durability, performance. Natural antioxidants such tocopherols, flavonoids, tannins, extracted from plants or agri-food waste, present a alternative synthetic stabilizers by enhancing thermal stability polymers like poly(lactic acid) (PLA), poly(butylene succinate) (PBS), succinate-adipate) (PBSA), adipate-co-terephthalate) (PBAT), poly(hydroxyalkanoate) (PHA), starch-based materials. This review highlights recent advances stabilized with natural antioxidants, mechanisms action, role improving material properties for applications packaging. Additionally, it explores impact on recycling processes, advancements composite production techniques, future research directions. Bioplastics can achieve enhanced performance, reduce support circular economy incorporating antioxidants.

Язык: Английский

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