Multiple Sclerosis Journal,
Год журнала:
2023,
Номер
29(13), С. 1569 - 1577
Опубликована: Окт. 26, 2023
As
exercise
exerts
neurobiological
and
immunomodulatory
effects,
it
might
also
act
as
a
disease-modifying
intervention
in
MS.
However,
clear
mechanistic
link
between
effects
MS
has
yet
to
be
established.Establish
recommendations
for
future
studies
MS.In
regular
meetings,
members
of
the
mechanisms
action
group
within
MoXFo
(Moving
eXercise
research
Forward
MS)
initiative
evaluated
gaps
knowledge
discussed
unmet
needs
research.We
concluded
that
biomarkers
assessed
translational
humans
animals
are
essential
decipher
underlying
Consequently,
we
defined
definitions
different
types
examined
operationalized
their
use
align
with
question
optimal
testing
time
points.
Furthermore,
provide
key
considerations
improve
rigor
minimal
reporting
criteria
animal
studies.The
resulting
intended
quality
consequently
lead
better
understanding
therapeutic
approaches.
Research Quarterly for Exercise and Sport,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Апрель 22, 2025
The
relationship
between
functional
capacity
and
disability
status
in
individuals
with
Multiple
Sclerosis
(MS)
is
well
established.
However,
to
date,
the
interference
of
lower
limb
strength
this
classic
correlation
has
not
been
studied.
Therefore,
study
aimed
investigate
mediating
role
muscle
variables,
including
maximum
(MVIC)
explosive
(RFD),
status,
measured
by
Expanded
Disability
Status
Scale
(EDSS),
test
outcomes
a
MS
sample.
A
total
49
patients
performed
4
tests:
timed
up-and-go
(TUG),
sit-to-stand
(STS),
10-meter
walk
(10MWT),
6-minute
(6MWT),
as
measurement
MVIC
RFD.
statistical
mediation
analysis
was
conducted
examine
influence
on
EDSS
capacity.
Regarding
MVIC,
effect
6MWT
(indirect
=
48%,
p
.013),
10MWT
18.1%,
.015)
TUG
27.2%,
.003)
decreased.
RFD
late
(0-200),
34.8%
.0048),
18.0%,
.021)
25.0%,
.014)
variables
play
significant
PLoS ONE,
Год журнала:
2025,
Номер
20(5), С. e0323821 - e0323821
Опубликована: Май 22, 2025
Traditional
methods
for
evaluating
postoperative
human
motion
in
orthopedics
suffer
from
high
equipment
costs,
time-consuming
detection
processes,
and
can
only
provide
static
two-dimensional
image
information.
To
improve
the
efficiency
accuracy
of
assessment
orthopedics,
this
study
proposes
an
improved
algorithm
on
basis
kinematic
constraints
inertial
measurement
units
orthopedics.
Compared
with
other
methods,
average
error
standard
deviation
measuring
joint
range
after
orthopedic
surgery
based
were
smallest.
The
wrist
1.23°
1.63°,
respectively.
highest.
4s
98%,
calculating
Angle
is
also
better
than
traditional
algorithms.
method
has
applicability,
which
effectively
monitoring
reduce
support
personalized
management
intervention,
further
providing
reference
optimization
Behavioral Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Июнь 7, 2024
There
is
increasing
interest
by
researchers
and
clinicians
in
behavior
change
interventions
for
promoting
physical
activity
persons
newly
diagnosed
with
MS.
Ideally,
such
require
the
delivery
of
techniques
(BCTs)
based
on
theory
selection
BCTs
might
further
tailoring
this
MS
subpopulation.
The
current
study
examined
preferred
informing
design
early-stages
We
recruited
interviewed
20
(i.e.,
disease
duration
≤
2
years).
interviews
were
conducted
online
via
video
conferencing
platform
followed
a
semi-structured
script.
During
interviews,
participants
provided
opinions
regarding
an
ideal
program,
mapped
Intervention
Functions
Behavior
Change
Wheel,
BCTs,
BCT
groups.
Ten
frequently
mentioned
identified
as
strategies
intervention
among
These
focused
providing
social
support,
skills
performance
regulation,
knowledge
benefits
This
research
provides
refined
list
that
can
be
included
when
designing
tailored
European Journal of Neurology,
Год журнала:
2024,
Номер
31(10)
Опубликована: Авг. 7, 2024
Healthy
lifestyle
behaviour
modification
may
improve
health
outcomes
in
people
with
multiple
sclerosis
(pwMS),
but
empirical
evidence
is
needed
to
confirm
prior
study
findings.
We
developed
an
online
multimodal
intervention
(Multiple
Sclerosis
Online
Course)
examine
the
impact
of
on
pwMS
via
a
randomized
control
trial
(RCT).
However,
present
specifically
analyses
baseline
data
assess
engagement
healthy
lifestyles
by
RCT
participants
and
cross-sectional
associations
outcomes.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 25, 2024
Multiple
sclerosis
(MS)
is
a
progressively
debilitating
disorder
that
has
seen
notable
rise
in
prevalence
recent
years.
This
study
examines
the
burden
of
MS
from
1990
to
2019,
providing
detailed
analysis
by
age,
sex,
and
sociodemographic
index
(SDI)
across
204
countries
territories.
Cells,
Год журнала:
2024,
Номер
13(23), С. 1940 - 1940
Опубликована: Ноя. 22, 2024
Background:
Regular
physical
activity
plays
a
crucial
role
in
modulating
cellular
metabolism
and
mitigating
the
progression
of
neurodegenerative
diseases
such
as
Alzheimer’s,
Parkinson’s,
Multiple
Sclerosis.
Objective:
The
objective
this
review
is
to
evaluate
molecular
mechanisms
by
which
exercise
influences
metabolism,
with
focus
on
its
potential
therapeutic
intervention
for
neurological
disorders.
Methods:
A
comprehensive
literature
was
conducted
using
peer-reviewed
scientific
articles,
period
between
2015
2024,
analyze
effects
mitochondrial
function,
oxidative
stress,
metabolic
health.
Results:
findings
indicate
that
promotes
biogenesis,
enhances
phosphorylation,
reduces
reactive
oxygen
species,
contributing
improved
energy
production
resilience.
These
adaptations
are
associated
delayed
disease
reduced
symptoms
patients
conditions.
Additionally,
integrating
nutritional
strategies
may
further
enhance
outcomes
addressing
disturbances
comprehensively.
Conclusions:
This
concludes
personalized
protocols
should
be
developed
optimize
benefits
diseases,
while
future
research
biomarker
development
individualized
treatment
approaches.
highlight
importance
non-pharmacological
interventions
managing
diseases.
Neurological Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Апрель 7, 2025
This
study
aimed
to
evaluate
the
effects
of
PNF
on
pain,
motor
function,
fatigue,
and
quality
life
in
MS
patients.
A
randomized,
controlled,
single-blind
was
conducted.
Forty-four
patients
were
randomly
assigned
either
Group
(PNFG,
n
=
22,
16
female)
or
Control
(CG,
female).
PNFG
underwent
supervised
combined
aerobic
training
thrice
weekly
for
8
weeks,
while
CG
followed
a
home
exercise
regimen.
Various
measures
employed,
including
Visual
Analogue
Scale
(VAS)
Timed
Up
Go
(TUG)
test,
Functional
Reach
Test
(FRT),
Six-Minute
Walk
(6-MWT),
Fatigue
Severity
(FSS),
Impact
(FIS),
Dexterity
Questionnaire-24
(DextQ-24)
Multiple
Sclerosis
Quality
Life-54
(MSQoL-54).
exhibited
significant
improvements
VAS
(p
0.000),
FRT
0.001),
TUG
6-MWT
FIS
0.007),
DextQ-24
0.033),
MSQoL-54
scores
(Physical
Health
Composite,
Mental
p
0.005,
0.002,
respectively)
<
0.05).
also
showed
0.018),
FSS
0.006),
psychosocial
function
0.017,
0.001,
respectively),
ADL
0.045)
outperformed
(Dressing,
0.038)
subscales
(emotional
well-being,
energy,
health
perception,
0.007,
0.037,
0.044,
is
first
randomized
controlled
trial
show
that
improves
upper
limb
(skill)
physiotherapy
effectively
improved
fatigue
life,
with
group
achieving
better
outcomes.
Both
modalities
offered
accessible
rehabilitation
options.
