Vitamin B6 status is related to disease severity and modulated by endurance exercise in individuals with multiple sclerosis: a secondary analysis of a randomized controlled trial

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Role of Maximum and Explosive Strength in the Relationship Between the Expanded Disability Status Scale (EDSS) and Functional Capacity in People with Multiple Sclerosis: A Mediation Analysis

Research Quarterly for Exercise and Sport, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: April 22, 2025

The relationship between functional capacity and disability status in individuals with Multiple Sclerosis (MS) is well established. However, to date, the interference of lower limb strength this classic correlation has not been studied. Therefore, study aimed investigate mediating role muscle variables, including maximum (MVIC) explosive (RFD), status, measured by Expanded Disability Status Scale (EDSS), test outcomes a MS sample. A total 49 patients performed 4 tests: timed up-and-go (TUG), sit-to-stand (STS), 10-meter walk (10MWT), 6-minute (6MWT), as measurement MVIC RFD. statistical mediation analysis was conducted examine influence on EDSS capacity. Regarding MVIC, effect 6MWT (indirect = 48%, p .013), 10MWT 18.1%, .015) TUG 27.2%, .003) decreased. RFD late (0-200), 34.8% .0048), 18.0%, .021) 25.0%, .014) variables play significant

Language: Английский

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Clinical variables influencing the perception of fatigue in people with multiple sclerosis: a cross-sectional study using FSIQ-RMS

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 25, 2024

Abstract Background Physical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence development fatigue, such as gender, education, body mass index (BMI), Expanded Disability Status Scale (EDSS), disease duration, working status (Ws), physiotherapy (Ph), and disease-modifying therapies (DMTs). Fatigue Symptoms Impacts Questionnaire-Relapsing (FSIQ-RMS) a patient-reported outcome (PRO) that allows to define impact PwMS clearly. This study aimed assess on by using FSIQ-RMS. Methods The participants were enrolled from May July 2021 MS Centers Sant’Andrea Hospital Policlinico Umberto I Rome. was evaluated FSIQ-RMS, validated, culturally adapted Italian. Clinical demographic data collected at same time. Results We 178 [Female 74.16%; RMS 82.58%, SPMS 17.52%]. FSIQ-RMS scores significantly correlated EDSS (p-value < 0.01). Analysis variance between means showed statistically significant difference BMI groups 24hours_FSIQ-RMS score 7days_FSIQ-RMS ( p 0.01), lower group having highest scores. Furthermore, perceived improved both subjects performing Ph 0.05) those who actively work Conclusions use real-world setting confirmed underweight high levels disability are closely related fatigue. In addition, active Ws strongly PwMS.

Language: Английский

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Advanced neuroimaging techniques to explore the effects of motor and cognitive rehabilitation in multiple sclerosis

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(7), P. 3806 - 3848

Published: May 1, 2024

Language: Английский

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Global burden of multiple sclerosis and its attributable risk factors, 1990–2019

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Multiple sclerosis (MS) is a progressively debilitating disorder that has seen notable rise in prevalence recent years. This study examines the burden of MS from 1990 to 2019, providing detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries territories.

Language: Английский

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An Immersive Virtual Kitchen Training System for People with Multiple Sclerosis: A Development and Validation Study

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(9), P. 3222 - 3222

Published: April 30, 2023

Rehabilitation via virtual reality (VR) training tools allows repetitive, intensive, and task-specific practice in a controlled safe environment. Our goal was to develop validate novel immersive VR system based on the of real-life activities kitchen environment people with multiple sclerosis (pwMS) upper-limb dysfunction. The application includes several tasks, i.e., tidying up kitchen, preparing hamburger soup meal, dish washing. Following development phase, tested for an 8-week intervention period small sample pwMS suffering from Suitability Evaluation Questionnaire systems served as primary outcome. scores enjoyment, sense comfort system, feelings success control, realism, easy-to-understand instructions, assists rehabilitation therapy, were between 4.0 4.6, indicating high satisfaction. eye discomfort, dizziness, nausea, disorientation during 2.8 1.3, low-to-moderate interference system. is feasible paves way future RCTs examine benefits compared standard care, thus improving functionality upper limbs pwMS.

Language: Английский

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A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(10), P. 7307 - 7336

Published: May 11, 2024

Language: Английский

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Preferred Behavior Change Techniques for Physical Activity Interventions among Persons Newly Diagnosed with Multiple Sclerosis: A Qualitative Study

Behavioral Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: June 7, 2024

There is increasing interest by researchers and clinicians in behavior change interventions for promoting physical activity persons newly diagnosed with MS. Ideally, such require the delivery of techniques (BCTs) based on theory selection BCTs might further tailoring this MS subpopulation. The current study examined preferred informing design early-stages We recruited interviewed 20 (i.e., disease duration ≤ 2 years). interviews were conducted online via video conferencing platform followed a semi-structured script. During interviews, participants provided opinions regarding an ideal program, mapped Intervention Functions Behavior Change Wheel, BCTs, BCT groups. Ten frequently mentioned identified as strategies intervention among These focused providing social support, skills performance regulation, knowledge benefits This research provides refined list that can be included when designing tailored

Language: Английский

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Environmental factors related to multiple sclerosis progression

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 464, P. 123161 - 123161

Published: Aug. 6, 2024

Language: Английский

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Baseline engagement with healthy lifestyles and their associations with health outcomes in people with multiple sclerosis enrolled in an online multimodal lifestyle course

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(10)

Published: Aug. 7, 2024

Healthy lifestyle behaviour modification may improve health outcomes in people with multiple sclerosis (pwMS), but empirical evidence is needed to confirm prior study findings. We developed an online multimodal intervention (Multiple Sclerosis Online Course) examine the impact of on pwMS via a randomized control trial (RCT). However, present specifically analyses baseline data assess engagement healthy lifestyles by RCT participants and cross-sectional associations outcomes.

Language: Английский

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