eNeuro, Год журнала: 2024, Номер 11(9), С. ENEURO.0183 - 24.2024
Опубликована: Сен. 1, 2024
Язык: Английский
Physics of Life Reviews, Год журнала: 2024, Номер 48, С. 132 - 161
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
10
Journal of Parkinson s Disease, Год журнала: 2023, Номер 13(4), С. 453 - 471
Опубликована: Май 10, 2023
Parkinson's disease (PD) is a neurodegenerative with heavy burden on patients, families, and society. Deep brain stimulation (DBS) can improve the symptoms of PD patients for whom medication insufficient. However, current open-loop uninterrupted conventional DBS (cDBS) has inherent limitations, such as adverse effects, rapid battery consumption, need frequent parameter adjustment. To overcome these shortcomings, adaptive (aDBS) was proposed to provide responsive optimized PD. This topic attracted scientific interest, growing body preclinical clinical evidence shown its benefits. both achievements challenges have emerged in this novel field. date, only limited reviews comprehensively analyzed full framework procedures aDBS implementation. Herein, we review data discuss achievement future perspectives treatment.
Язык: Английский
Процитировано
18
npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)
Опубликована: Фев. 21, 2024
Abstract Beta hypersynchrony was recently introduced into clinical practice in Parkinson’s disease (PD) to identify the best stimulation contacts and for adaptive deep brain (aDBS) sensing. However, many other oscillopathies accompany disease, beta power sensing may not be optimal all patients. The aim of this work study potential usefulness phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded analyzed PD patients ( n = 19). HFOs evaluated a resting-state condition; PAC then studied compared electrode contact positions, structural connectivity, medication state. Beta-HFO (mainly 200–500 Hz range) observed subjects. detectable more specifically motor part STN HFOs. Moreover, presence better corresponds setup based on effect. is also sensitive laterality symptoms dopaminergic therapy, where greater cluster reflects affected side “off” Coupling between known correlate seems than itself could helpful selection probably as future input signal aDBS.
Язык: Английский
Процитировано
8
European Journal of Neuroscience, Год журнала: 2025, Номер 61(1)
Опубликована: Янв. 1, 2025
ABSTRACT Excessive beta oscillations in the subthalamic nucleus are established as a primary electrophysiological biomarker for motor impairment Parkinson's disease and currently used feedback signals adaptive deep brain stimulation systems. However, there is still need optimization of parameters identification optimal biomarkers that can accommodate varying patient conditions, such ON OFF levodopa medication. The precise boundaries ‘pathological’ oscillatory ranges, associated with different aspects impairment, not fully clarified. In this study, we hypothesized analysing periodic aperiodic components activity separately identifying functionally distinct subranges within 8–35 Hz based on properties may reveal robust specific impairment. We analysed 14 patients disease. Local field potentials were recorded at rest from externalized electrodes postoperatively, both before after administration. showed administration suppressed across broad frequency range (11–32 Hz) increased slope component. Changes correlated symptom alleviation. Periodic was linked to severity: Peak amplitude 14‐ 20‐Hz overall state, whereas 7‐ 11‐Hz bradykinesia state. Our findings suggest that, addition low beta, alpha component serve promising potential DBS
Язык: Английский
Процитировано
1
Movement Disorders, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Abstract Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep stimulation (DBS), a comprehensive comparison of their profiles is lacking. Objectives To systematically compare the neurophysiological dynamics clinical properties three biomarkers—low‐frequency, beta (β), finely tuned γ (FTG) activity. Methods We investigated 14 PD patients implanted Medtronic Percept PC, who underwent up two 4‐week multimodal recording periods on regular stimulation. Subthalamic nucleus local field potentials (LFPs) low‐frequency, β, FTG were recorded. Additionally, objective motor states, physical heart rate using wearables, as well medication‐intake times, sleep‐awake subjective diaries co‐registered. LFP also compared high‐resolution in‐hospital recordings under off / dopaminergic conditions. Results reliably indexed setting at group individual levels, these spectral could be anticipated by recordings. Both low‐frequency correlated wearable‐based dyskinesia scores, whereas diary‐based events only linked FTG. Importantly, indicated ‐medication regardless presence despite potential motion artifacts. The 24‐hour profile revealed large circadian power shifts that may overdrive dynamics. Conclusion Despite limitations low‐temporal resolution recordings, this work provides valuable insights into biomarkers. Specifically, it highlights utility primary reliable indicator DBS. © 2025 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Язык: Английский
Процитировано
1
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Март 25, 2025
Abstract Deep brain stimulation (DBS) is a neuroelectronic therapy for the treatment of broad range neurological disorders, including Parkinson’s disease. Current DBS technologies face important limitations, such as large electrode size, invasiveness, and lack adaptive based on biomarker monitoring. In this study, we investigate potential benefits using nanoporous reduced graphene oxide (rGO) technology in DBS, by implanting flexible high-density array rGO microelectrodes (25 µm diameter) subthalamic nucleus (STN) healthy hemi-parkinsonian rats. We demonstrate that these record action potentials with high signal-to-noise ratio, allowing precise localization STN tracking multiunit-based Parkinsonian biomarkers. The bidirectional capability to deliver focal high-fidelity signals unlocks visualization local neuromodulation multiunit biomarker. These findings high-resolution neural interfaces closed-loop preclinical models.
Язык: Английский
Процитировано
1
Movement Disorders, Год журнала: 2023, Номер 38(5), С. 818 - 830
Опубликована: Март 28, 2023
Abstract Background The landscape of neurophysiological symptoms and behavioral biomarkers in basal ganglia signals for movement disorders is expanding. clinical translation sensing‐based deep brain stimulation (DBS) also requires a thorough understanding the anatomical organization spectral within subthalamic nucleus (STN). Objectives aims were to systematically investigate topography, including wide range sub‐bands STN local field potentials (LFP) Parkinson's disease (PD) patients, evaluate its predictive performance response DBS. Methods STN‐LFPs recorded from 70 PD patients (130 hemispheres) awake at rest using multicontact DBS electrodes. A comprehensive spatial characterization, hot spot localization focality estimation, was performed multiple (delta, theta, alpha, low‐beta, high‐beta, low‐gamma, high‐gamma, fast‐gamma (FG) as well low‐ fast high‐frequency oscillations [HFO]) compared rigidity biomarker map established used predict Results shows heterogeneous topographic distribution different biomarkers, with strongest segregation inferior‐superior axis. Relative superiorly localized beta spot, HFOs (FG, slow HFO) up 2 mm more inferiorly. Beta are spatially spread other sub‐bands. Both proximity contacts distance higher‐frequency spots best Conclusions properties target structure can additionally be informative implementation next‐generation © 2023 Authors. Movement Disorders published by Wiley Periodicals LLC on behalf International Parkinson Disorder Society.
Язык: Английский
Процитировано
15
npj Parkinson s Disease, Год журнала: 2023, Номер 9(1)
Опубликована: Март 11, 2023
Although subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson's disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes optimizing DBS parameter settings, which may contribute to inefficacies. One that could aid efficacy the orientation current administered, albeit precise mechanisms underlying optimal contact orientations and associated benefits are not well understood. Herein, 24 PD received monopolar left STN during magnetoencephalography standardized movement protocols interrogate directional specificity STN-DBS administration on accelerometer metrics fine hand movements. Our findings demonstrate elicit larger DBS-evoked cortical responses ipsilateral sensorimotor cortex, importantly, differentially predictive smoother profiles contact-dependent manner. Moreover, we summarize traditional evaluations (e.g., therapeutic windows, side effects) comprehensive review optimal/non-optimal settings. Together, these data suggest quantitative provide insight characterizing parameters necessary symptoms future.
Язык: Английский
Процитировано
14
Parkinsonism & Related Disorders, Год журнала: 2023, Номер 110, С. 105364 - 105364
Опубликована: Март 20, 2023
Язык: Английский
Процитировано
12
Deep Brain Stimulation, Год журнала: 2023, Номер 2, С. 1 - 5
Опубликована: Май 16, 2023
ObjectivesParkinson patients with chronic DBS routinely receive sensing-enabled implantable pulse generators upon battery replacement. Here we aimed to assess whether and/or how local field potential based reprogramming may be of use in this population.MethodsIn four Parkinson on treatment bilateral STN-DBS and implanted the Percept™ PC generator, employed an approach select stimulation contacts amplitudes beta-activity. When applicable, effect parameter adjustments effectiveness DBS-induced side effects was assessed.ResultsIn one out eight electrodes, LFP-guided contact different from clinically determined one. Beta-based therapeutic windows could defined five electrodes. were performed two patients, resulting improved motor fluctuations decreased stimulation-induced respectively.DiscussionLFP-guided has improve decrease selected cases. Prospective controlled research is required clinical usefulness reprogramming.
Язык: Английский
Процитировано
12