Internal Medicine Journal,
Год журнала:
2024,
Номер
54(7), С. 1056 - 1065
Опубликована: Июнь 5, 2024
Normal-anion-gap
metabolic
acidosis
(NAGMA)
is
a
common
but
often
under-recognised
and
poorly
understood
condition,
especially
by
less-experienced
clinicians.
In
adults,
NAGMA
might
be
an
initial
clue
to
more
significant
underlying
pathology,
such
as
autoimmune
diseases,
hypergammaglobulinemia
or
drug
toxicities.
However,
identifying
the
aetiology
can
challenging
due
diverse
processes
involved
in
development
of
acidosis.
A
better
understanding
pathophysiology
help
treating
physicians
suspect
evaluate
condition
early
reach
correct
diagnosis.
This
article
provides
overview
renal
acid-base
regulation,
discusses
pathophysiological
developing
framework
for
evaluation
accurate
AJP Renal Physiology,
Год журнала:
2023,
Номер
324(6), С. F532 - F543
Опубликована: Апрель 27, 2023
Phosphoenolpyruvate
carboxykinase
1
(PCK1)
is
highly
expressed
in
the
proximal
tubule.
We
show
here
that
this
enzyme
crucial
for
maintenance
of
normal
tubular
physiology,
lactate,
and
glucose
homeostasis.
PCK1
a
regulator
acid-base
balance
ammoniagenesis.
Preventing
downregulation
during
renal
injury
improves
function,
rendering
it
an
important
target
disease.
Clinical Kidney Journal,
Год журнала:
2023,
Номер
16(8), С. 1249 - 1257
Опубликована: Март 14, 2023
ABSTRACT
Chronic
kidney
disease
(CKD)
is
a
global
health
issue
with
increasing
prevalence.
Despite
large
improvements
in
current
therapies,
slowing
CKD
progression
remains
challenge.
A
better
understanding
of
renal
pathophysiology
needed
to
offer
new
therapeutic
targets.
The
role
metabolism
alterations
and
mitochondrial
dysfunction
tubular
cells
increasingly
recognized
progression.
In
proximal
cells,
associated
switch
from
fatty
acid
oxidation
glycolysis.
Glucose
synthesis
through
gluconeogenesis
one
the
principal
physiological
functions
kidney.
Loss
stage-dependent
manner
key
feature
contributes
systemic
possibly
local
metabolic
complications.
consequences
observed
may
be
related
an
accumulation
precursors,
such
as
glycogen,
but
also
various
enzymes.
basic
features
their
modifications
during
will
reviewed.
influence
on
described,
well
consequences.
Finally,
interventions
discussed.
ACS Sensors,
Год журнала:
2024,
Номер
9(5), С. 2622 - 2633
Опубликована: Май 3, 2024
Early
diagnosis
of
drug-induced
kidney
injury
(DIKI)
is
essential
for
clinical
treatment
and
intervention.
However,
developing
a
reliable
method
to
trace
origins
through
retrospective
studies
remains
challenge.
In
this
study,
we
designed
ordered
fried-bun-shaped
Au
nanocone
arrays
(FBS
NCAs)
create
microarray
chips
as
surface-enhanced
Raman
scattering
(SERS)
analysis
platform.
Subsequently,
the
principal
component
(PCA)-two-layer
nearest
neighbor
(TLNN)
model
was
constructed
identify
analyze
SERS
spectra
exosomes
from
renal
induced
by
cisplatin
gentamycin.
The
established
PCA-TLNN
successfully
differentiated
at
different
stages
causes,
capturing
most
significant
spectral
features
distinguishing
these
variations.
For
induction
times,
accuracy
reached
97.8%
(cisplatin)
93.3%
(gentamicin).
caused
agents,
100%
(7
days)
96.7%
(14
days).
This
study
demonstrates
that
combination
label-free
exosome
machine
learning
could
serve
an
innovative
strategy
medical
therapeutic
Pflügers Archiv - European Journal of Physiology,
Год журнала:
2024,
Номер
476(4), С. 579 - 592
Опубликована: Янв. 27, 2024
Abstract
Metabolic
acidosis
is
a
frequent
complication
in
non-transplant
chronic
kidney
disease
(CKD)
and
after
transplantation.
It
occurs
when
net
endogenous
acid
production
exceeds
excretion.
While
nephron
loss
with
reduced
ammoniagenesis
the
main
cause
of
retention
CKD
patients,
additional
pathophysiological
mechanisms
are
likely
inflicted
transplant
recipients.
Functional
tubular
damage
by
calcineurin
inhibitors
seems
to
play
key
role
causing
renal
acidosis.
Notably,
experimental
clinical
studies
over
past
decades
have
provided
evidence
that
metabolic
may
not
only
be
consequence
but
also
driver
disease.
In
acidosis,
activation
hormonal
systems
complement
system
resulting
fibrosis
been
described.
Further
changes
metabolism
will
contribute
deeper
understanding
pathophysiology
CKD.
alkali
supplementation
case
serum
bicarbonate
<
22
mmol/l
has
endorsed
guidelines
for
many
years
slow
functional
decline,
among
other
considerations,
beneficial
effects
thresholds
treatment
lately
under
intense
debate.
This
review
article
discusses
this
topic
light
most
recent
results
trials
assessing
efficacy
dietary
pharmacological
interventions
patients.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(10), С. 12797 - 12808
Опубликована: Март 3, 2023
To
date,
imaging-guided
multimodality
therapy
is
important
to
improve
the
accuracy
of
diagnosis
renal
fibrosis,
and
nanoplatforms
for
are
gaining
more
attention.
There
many
limitations
deficiencies
in
clinical
use
early-stage
multimodal
imaging
can
contribute
thoroughly
provide
in-detail
information
effective
diagnosis.
Melanin
an
endogenous
biomaterial,
we
developed
ultrasmall
particle
size
melanin
nanoprobe
(MNP-PEG-Mn)
based
on
photoacoustic
(PA)
magnetic
resonance
(MR)
dual-modal
imaging.
MNP-PEG-Mn
nanoprobe,
with
average
diameter
about
2.7
nm,
be
passively
targeted
accumulation
kidney,
it
has
excellent
free
radical
scavenging
antioxidant
abilities
without
further
exacerbating
fibrosis.
Using
normal
group
signal
as
a
control,
results
showed
that
MR
(MAI)
PA
(PAI)
signals
reached
strongest
at
6
h
when
entered
7
day
fibrosis
via
left
vein
tail
end
mice;
however,
strength
gradient
change
were
significantly
weaker
28
than
group.
The
phenomenon
preliminarily
indicates
PAI/MRI
dual-modality
contrast
medium
candidate,
outstanding
ability
application
potential.
Background
The
early
identification
of
patients
at
high
risk
for
acute
kidney
injury
(AKI)
with
a
poor
prognosis
is
crucial
to
prevent
complications
and
minimize
mortality.
This
study
sought
investigate
the
association
between
albumin-corrected
anion
gap
(ACAG)
all-cause
mortality
among
critically
ill
AKI.
PeerJ,
Год журнала:
2024,
Номер
12, С. e17316 - e17316
Опубликована: Апрель 29, 2024
This
review
discusses
the
importance
of
homeostasis
with
a
particular
emphasis
on
acid-base
(AB)
balance,
crucial
aspect
pH
regulation
in
living
systems.
Two
primary
organ
systems
correct
deviations
from
standard
balance:
respiratory
system
via
gas
exchange
and
kidneys
proton/bicarbonate
secretion
reabsorption.
Focusing
kidney
functions,
we
describe
complexity
renal
architecture
its
challenges
for
experimental
research.
We
address
specific
roles
different
nephron
segments
(the
proximal
convoluted
tubule,
loop
Henle
distal
tubule)
homeostasis,
while
explaining
physiological
significance
ion
processes
maintained
by
kidneys,
particularly
role
bicarbonate
ions
(HCO
3
−
)
as
an
essential
buffer
body.
The
will
be
interest
to
researchers
fields
physiology,
biochemistry
molecular
biology,
which
builds
strong
foundation
critically
evaluates
existing
studies.
Our
helps
identify
gaps
knowledge
thoroughly
understanding
literature
related
homeostasis.
