Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

Chemical Society Reviews, Год журнала: 2010, Номер 40(1), С. 387 - 426

Опубликована: Авг. 17, 2010

The study of biological systems in a holistic manner (systems biology) is increasingly being viewed as necessity to provide qualitative and quantitative descriptions the emergent properties complete system. Systems biology performs studies focussed on complex interactions system components; emphasising whole rather than individual parts. Many perturbations mammalian (diet, disease, drugs) are multi-factorial small parts insufficient understand phenotypic changes induced. Metabolomics one functional level tool employed investigate metabolites with other (metabolism) but also regulatory role through interaction genes, transcripts proteins (e.g. allosteric regulation). Technological developments driving force behind advances scientific knowledge. Recent two analytical platforms mass spectrometry (MS) nuclear magnetic resonance (NMR) spectroscopy have driven forward discipline metabolomics. In this critical review, an introduction metabolites, metabolomes, metabolomics MS NMR will be provided. applications for health-disease continuum, drug efficacy toxicity dietary effects health reviewed. current limitations future goals discussed (374 references).

Язык: Английский

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The food metabolome: a window over dietary exposure

American Journal of Clinical Nutrition, Год журнала: 2014, Номер 99(6), С. 1286 - 1308

Опубликована: Апрель 24, 2014

Язык: Английский

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Review and evaluation of innovative technologies for measuring diet in nutritional epidemiology

International Journal of Epidemiology, Год журнала: 2012, Номер 41(4), С. 1187 - 1203

Опубликована: Авг. 1, 2012

Introduction The use of innovative technologies is deemed to improve dietary assessment in various research settings. However, their relative merits nutritional epidemiological studies, which require accurate quantitative estimates the usual intake at individual level, still need be evaluated. Objective To report on inventory available for and critically evaluate strengths weaknesses as compared with conventional methodologies (i.e. Food Frequency Questionnaires, food records, 24-hour recalls) used studies. Methods A list currently was identified from English-language journals, using PubMed Web Science. search criteria were principally based date publication (between 1995 2011) pre-defined keywords. Results Six main groups ('Personal Digital Assistant-', 'Mobile-phone-', 'Interactive computer-', 'Web-', 'Camera- tape-recorder-' 'Scan- sensor–based' technologies). Compared Personal Assistant mobile phone devices seem recording through possibility 'real-time' eating events, but validity estimate intakes low moderate. In recalls, there limited knowledge regarding accuracy fully automated approaches; methodological problems, such inaccuracy self-reported portion sizes might more critical than interview-based applications. contrast, measurement errors web-based paper-based Questionnaires are most likely similar, suggesting that underlying methodology unchanged by technology. Conclusions Most new seen have overlapping features methods predominantly epidemiology. Their potential enhance cost- time-effective, less laborious ways data collection higher subject acceptance, though integration studies would additional considerations, study objectives, target population financial resources available. even technologies, inherent bias related will not resolved. More therefore crucial investigate technologies.

Язык: Английский

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Dietary assessment methods in epidemiological research: current state of the art and future prospects

F1000Research, Год журнала: 2017, Номер 6, С. 926 - 926

Опубликована: Июнь 16, 2017

Self-reported dietary intake is assessed by methods of real-time recording (food diaries and the duplicate portion method) recall (dietary histories, food frequency questionnaires, 24-hour recalls). Being less labor intensive, are more frequently employed in nutritional epidemiological investigations. However, sources error, which include participants’ inability to fully accurately their intakes as well limitations inherent composition databases applied convert reported consumption energy nutrient intakes, may limit validity generated information. The use biomarkers often recommended overcome such errors better capture intra-individual variability intake; nevertheless, it has its own challenges. To address measurement error associated with large investigations integrate sub-studies for validation calibration questionnaires and/or administer a combination different assessment (e.g. administration biomarker levels). Recent advances omics field could enrich list reliable nutrition biomarkers, whereas new approaches employing web-based smart phone applications reduce respondent burden and, possibly, reporting bias. Novel technologies increasingly integrated traditional methods, but some still remain. In analyses, always need be adjusted total daily account related reporting.

Язык: Английский

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Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies

American Journal of Clinical Nutrition, Год журнала: 2018, Номер 108(5), С. 1069 - 1091

Опубликована: Апрель 27, 2018

High dietary intake or blood concentrations (as biomarkers of intake) vitamin C, carotenoids, and E have been associated with reduced risk cardiovascular disease, cancer, mortality, but these associations not systematically assessed.

Язык: Английский

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Induction of Epigenetic Alterations by Dietary and Other Environmental Factors

Advances in genetics, Год журнала: 2010, Номер unknown, С. 3 - 39

Опубликована: Янв. 1, 2010

Язык: Английский

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Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies

American Journal of Clinical Nutrition, Год журнала: 2010, Номер 93(2), С. 314 - 321

Опубликована: Дек. 23, 2010

Язык: Английский

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Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations

American Journal of Clinical Nutrition, Год журнала: 2014, Номер 100(1), С. 208 - 217

Опубликована: Апрель 17, 2014

Язык: Английский

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Dietary biomarkers: advances, limitations and future directions

Nutrition Journal, Год журнала: 2012, Номер 11(1)

Опубликована: Дек. 1, 2012

The subjective nature of self-reported dietary intake assessment methods presents numerous challenges to obtaining accurate and nutritional status. This limitation can be overcome by the use biomarkers, which are able objectively assess consumption (or exposure) without bias errors. need for biomarkers was addressed Institute Medicine, who recognized lack as a knowledge gap requiring future research. purpose this article is review existing literature on currently available including novel specific foods components, validity, reliability sensitivity markers. revealed several in additional validation research; research also needed produce sensitive, specific, cost-effective noninvasive biomarkers. emerging field metabolomics may help advance development food/nutrient yet advances food metabolome databases needed. availability that estimate components could greatly enhance targeting compliance national recommendations well direct associations with disease outcomes. More necessary refine accounting confounding factors, establish new indicators intake, develop techniques cost-effective, noninvasive, rapid measures

Язык: Английский

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Identifying biomarkers of dietary patterns by using metabolomics

American Journal of Clinical Nutrition, Год журнала: 2016, Номер 105(2), С. 450 - 465

Опубликована: Дек. 29, 2016

Язык: Английский

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