PubMed,
Год журнала:
2024,
Номер
49(4), С. 205 - 218
Опубликована: Апрель 1, 2024
Physical
activity
has
a
positive
effect
on
human
health
and
emotional
well-being.
However,
in
both
amateur
professional
athletes,
training
poses
risk
of
acute
or
chronic
injury
through
repetitive
overloading
bones,
joints,
muscles.
Inflammation
can
be
an
adverse
intense
exercise
caused
by
several
factors
including
oxidative
stress.
The
present
narrative
review
summarizes
current
knowledge
inflammatory
markers
induced
physical
exercise.
Post-exercise
recovery
may
reduce
responses
is
key
to
effective
adaptation
muscle
tissues
sustained
exertion.
Cell Death and Disease,
Год журнала:
2021,
Номер
12(11)
Опубликована: Окт. 18, 2021
Lysosomes
are
organelles
involved
in
cell
metabolism,
waste
degradation,
and
cellular
material
circulation.
They
play
a
key
role
the
maintenance
of
physiological
homeostasis.
Compared
with
lysosomal
content
other
organs,
that
kidney
is
abundant,
abnormalities
associated
occurrence
development
certain
renal
diseases.
Lysosomal
structure
function
intrinsic
cells
impaired
diabetic
disease
(DKD).
Promoting
biosynthesis
and/or
restoring
can
repair
damaged
podocytes
proximal
tubular
epithelial
cells,
delay
progression
DKD.
homeostasis
may
be
advantageous
alleviating
Here,
we
systematically
reviewed
latest
advances
relationship
between
dyshomeostasis
DKD
based
on
recent
literature
to
further
elucidate
mechanism
injury
diabetes
mellitus
highlight
application
potential
as
new
prevention
treatment
strategy
for
However,
research
screening
effective
interventions
still
its
infancy,
thus
should
focus
future
studies.
The
out
cell-specific
regulation
targets
according
different
stages
DKD,
so
realize
controllable
targeted
during
successful
clinical
this
therapeutic
strategy.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 10, 2023
Diabetic
kidney
disease
(DKD)
is
a
major
microvascular
complication
of
diabetes
and
leading
cause
end-stage
renal
worldwide.
Autophagy
plays
an
important
role
in
maintaining
cellular
homeostasis
physiology.
In
DKD,
the
accumulation
advanced
glycation
end
products
induces
decreased
autophagy-related
protein
expression
transcription
factor
EB
(TFEB)
nuclear
transfer,
to
impaired
autophagy
lysosomal
function
blockage
autophagic
flux.
This
accelerates
resident
cell
injury
apoptosis,
mediates
macrophage
infiltration
phenotypic
changes,
ultimately
aggravated
proteinuria
fibrosis
DKD.
Natural
polyphenols
show
promise
treating
DKD
by
regulating
promoting
transfer
TFEB
repair.
review
summarizes
characteristics
potential
application
mechanisms
some
known
natural
as
regulators
with
goal
contributing
deeper
understanding
polyphenol
treatment
development
their
applications.
Finally,
we
point
out
limitations
current
research
provide
outlook
for
future
research.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 1, 2024
Abstract
Kidney
filtration
is
ensured
by
the
interaction
of
podocytes,
endothelial
and
mesangial
cells.
Immunoglobulin
accumulation
at
barrier
pathognomonic
for
glomerular
injury.
The
mechanisms
that
regulate
filter
permeability
are
unknown.
Here,
we
identify
a
pivotal
role
proteasome
in
specific
cell
type.
Combining
genetic
inhibitor-based
human,
pig,
mouse,
Drosophila
models
demonstrate
maintains
integrity,
with
podocytes
requiring
constitutive
cells
immunoproteasomal
activity.
Endothelial
immunoproteasome
deficiency
as
well
inhibition
disrupt
mice,
resulting
pathologic
immunoglobulin
deposition.
Mechanistically,
observe
reduced
endocytic
activity,
which
leads
to
altered
membrane
recycling
receptor
turnover.
This
work
expands
concept
(immuno)proteasome
control
protease
orchestrating
protein
degradation
antigen
presentation
endocytosis,
providing
new
therapeutic
targets
treat
disease-associated
accumulations.
Cellular Physiology and Biochemistry,
Год журнала:
2021,
Номер
55(S4), С. 68 - 95
Опубликована: Сен. 15, 2021
Protein
homeostasis
strongly
depends
on
the
targeted
and
selective
removal
of
unneeded
or
flawed
proteins,
protein
aggregates,
damaged
excess
organelles
by
two
main
intracellular
degradative
systems,
namely
ubiquitin
proteasomal
system
(UPS)
autophagosomal
lysosomal
system.
Despite
representing
completely
distinct
mechanisms
degradation,
which
underlie
differing
regulatory
mechanisms,
growing
evidence
suggests
that
UPS
autophagy
interact
especially
in
situations
overwhelming
impairment,
both
are
involved
podocyte
proteostasis
pathogenesis
injury.
The
differential
impact
biology
disease
development
progression
is
not
understood.
Recent
advances
understanding
role
reviewed
here.
Clinics,
Год журнала:
2021,
Номер
76, С. e2643 - e2643
Опубликована: Янв. 1, 2021
Fabry
disease
(FD)
is
an
X-linked
lysosomal
caused
by
variants
of
the
GLA
gene;
formation
defective
alpha-galactosidase
A
contributes
to
accumulation
substrates
in
several
organs.
Chronic
inflammation
thought
contribute
organ
damage
FD
patients.In
total,
36
classic
patients
(15
men/21
women)
and
25
healthy
controls
(20
men/8
were
assessed.
The
Mainz
Severity
Score
Index
(MSSI)
was
established
after
conducting
interviews
with
chart
review.
Serum
IL-6,
IL-1β,
TNF-α
levels
evaluated
both
groups.The
mean
age
(years)
for
43.1±15.4
that
47.4±12.2
(p>0.05).
Twenty-two
(59.5%)
treated
enzyme
replacement
therapy
(ERT).
IL-6
significantly
higher
than
controls.
Patients
ERT
had
serum
those
not
ERT.
There
no
difference
IL-1β
between
who
not.
MSSI
scores
correlated
(r=0.60,
p<0.001)
(r=0.45,
p<0.001).FD
associated
elevated
this
cohort.
ERT,
particularly,
women,
exhibited
ERT;
reflecting
greater
burden.
