A lysosome-targeted dual-responsive fluorescent probe for simultaneous detection of NO and H2S in living cells, wild-type C. elegans and zebrafish DOI

Qiao Zhao,

Fengying Yuan,

Bin Xiao

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 228, P. 112224 - 112224

Published: May 15, 2024

Language: Английский

The role of lysosomes in metabolic and autoimmune diseases DOI
Frédéric Gros, Sylviane Muller

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(6), P. 366 - 383

Published: March 9, 2023

Language: Английский

Citations

78
Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling DOI Creative Commons
Anastasiia D. Vlasova, Siarhei Bukhalovich, Diana F. Bagaeva

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3327 - 3349

Published: Jan. 1, 2024

Organelle optogenetics is an approach to control cell physiology by targeted expression of microbial rhodopsins in membranes subcellular organelles.

Language: Английский

Citations

5
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration DOI Creative Commons

Wiebke Sachs,

Lukas Blume, Desirée Loreth

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 1, 2024

Abstract Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at barrier pathognomonic for glomerular injury. The mechanisms that regulate filter permeability are unknown. Here, we identify a pivotal role proteasome in specific cell type. Combining genetic inhibitor-based human, pig, mouse, Drosophila models demonstrate maintains integrity, with podocytes requiring constitutive cells immunoproteasomal activity. Endothelial immunoproteasome deficiency as well inhibition disrupt mice, resulting pathologic immunoglobulin deposition. Mechanistically, observe reduced endocytic activity, which leads to altered membrane recycling receptor turnover. This work expands concept (immuno)proteasome control protease orchestrating protein degradation antigen presentation endocytosis, providing new therapeutic targets treat disease-associated accumulations.

Language: Английский

Citations

4
Relationship between lysosomal dyshomeostasis and progression of diabetic kidney disease DOI Creative Commons
Man Wu, Minjie Zhang, Yaozhi Zhang

et al.

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(11)

Published: Oct. 18, 2021

Lysosomes are organelles involved in cell metabolism, waste degradation, and cellular material circulation. They play a key role the maintenance of physiological homeostasis. Compared with lysosomal content other organs, that kidney is abundant, abnormalities associated occurrence development certain renal diseases. Lysosomal structure function intrinsic cells impaired diabetic disease (DKD). Promoting biosynthesis and/or restoring can repair damaged podocytes proximal tubular epithelial cells, delay progression DKD. homeostasis may be advantageous alleviating Here, we systematically reviewed latest advances relationship between dyshomeostasis DKD based on recent literature to further elucidate mechanism injury diabetes mellitus highlight application potential as new prevention treatment strategy for However, research screening effective interventions still its infancy, thus should focus future studies. The out cell-specific regulation targets according different stages DKD, so realize controllable targeted during successful clinical this therapeutic strategy.

Language: Английский

Citations

25
A Cys-regulated two-photon lysosomal targetable fluorescent probe and its application for the diagnosis of kidney diseases DOI
Yonghe Tang, Juanjuan Peng, Rui Guo

et al.

Journal of Luminescence, Journal Year: 2023, Volume and Issue: 257, P. 119745 - 119745

Published: Feb. 2, 2023

Language: Английский

Citations

10
Regulation of autophagy by natural polyphenols in the treatment of diabetic kidney disease: therapeutic potential and mechanism DOI Creative Commons
Tong‐Tong Liu, Qi Jin, Liping Yang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 10, 2023

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and leading cause end-stage renal worldwide. Autophagy plays an important role in maintaining cellular homeostasis physiology. In DKD, the accumulation advanced glycation end products induces decreased autophagy-related protein expression transcription factor EB (TFEB) nuclear transfer, to impaired autophagy lysosomal function blockage autophagic flux. This accelerates resident cell injury apoptosis, mediates macrophage infiltration phenotypic changes, ultimately aggravated proteinuria fibrosis DKD. Natural polyphenols show promise treating DKD by regulating promoting transfer TFEB repair. review summarizes characteristics potential application mechanisms some known natural as regulators with goal contributing deeper understanding polyphenol treatment development their applications. Finally, we point out limitations current research provide outlook for future research.

Language: Английский

Citations

10
The intelligent podocyte: sensing and responding to a complex microenvironment DOI
John F. Bertram, Luise A. Cullen‐McEwen, Vinícius Andrade‐Oliveira

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Lysosomes-targeting near-infrared fluorescent probe for the detection of pH in living cells DOI
Chang Liu, Huimin Yan, Jian Wu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2022, Volume and Issue: 278, P. 121368 - 121368

Published: May 11, 2022

Language: Английский

Citations

14
The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology DOI Creative Commons

Lukas Heintz,

Catherine Meyer-Schwesinger

Cellular Physiology and Biochemistry, Journal Year: 2021, Volume and Issue: 55(S4), P. 68 - 95

Published: Sept. 15, 2021

Protein homeostasis strongly depends on the targeted and selective removal of unneeded or flawed proteins, protein aggregates, damaged excess organelles by two main intracellular degradative systems, namely ubiquitin proteasomal system (UPS) autophagosomal lysosomal system. Despite representing completely distinct mechanisms degradation, which underlie differing regulatory mechanisms, growing evidence suggests that UPS autophagy interact especially in situations overwhelming impairment, both are involved podocyte proteostasis pathogenesis injury. The differential impact biology disease development progression is not understood. Recent advances understanding role reviewed here.

Language: Английский

Citations

16
Increased Serum Interleukin-6 and Tumor Necrosis Factor Alpha Levels in Fabry Disease: Correlation with Disease Burden DOI Creative Commons
Nilton Salles Rosa Neto, Judith Campos de Barros Bento, Valéria F. Caparbo

et al.

Clinics, Journal Year: 2021, Volume and Issue: 76, P. e2643 - e2643

Published: Jan. 1, 2021

Fabry disease (FD) is an X-linked lysosomal caused by variants of the GLA gene; formation defective alpha-galactosidase A contributes to accumulation substrates in several organs. Chronic inflammation thought contribute organ damage FD patients.In total, 36 classic patients (15 men/21 women) and 25 healthy controls (20 men/8 were assessed. The Mainz Severity Score Index (MSSI) was established after conducting interviews with chart review. Serum IL-6, IL-1β, TNF-α levels evaluated both groups.The mean age (years) for 43.1±15.4 that 47.4±12.2 (p>0.05). Twenty-two (59.5%) treated enzyme replacement therapy (ERT). IL-6 significantly higher than controls. Patients ERT had serum those not ERT. There no difference IL-1β between who not. MSSI scores correlated (r=0.60, p<0.001) (r=0.45, p<0.001).FD associated elevated this cohort. ERT, particularly, women, exhibited ERT; reflecting greater burden.

Language: Английский

Citations

13