Dopamine signals integrate innate and learnt valences to regulate memory dynamics DOI Creative Commons
Mark J. Schnitzer, Cheng Huang, Junjie Luo

и другие.

Research Square (Research Square), Год журнала: 2022, Номер unknown

Опубликована: Авг. 11, 2022

Abstract To survive in dynamic environments, animals make behavioral decisions based on innate and learnt information about the valences of sensory cues. In brains multiple species, valence signals are initially encoded by distinct neural populations1–7 but then reconverge downstream brain structures that guide choices6–9. This reconvergence hinges prior acquisition information, which turn might depend upon signals. However, it remains unknown whether how cues shape information. Here we show fruit fly brain, interactions between within interconnected short- long-term memory units mushroom body jointly regulate formation expression via modulation dopamine teaching By using time-lapse, vivo optical voltage imaging to record spiking with millisecond-resolution flies undergoing olfactory associative conditioning, found PPL1 neurons (PPL1-DANs) heterogeneously bi-directionally encode punishment, reward, odor-valence Learning modulates these representations a way combines allows PPL1-DANs storage their targets, output (MBONs). PPL1-γ1pedc PPL1-γ2α’1 control short-term formation. After repeated feedback carrying data from MBON-γ1pedc>α/β PPL1-α’2α2 PPL1-α3 allow cells previously promote long-lasting A computational model constrained connectome our explains integrate storage, extinction, traces. The yields non-intuitive predictions effects different training protocols, experiments confirm. Overall, achieves flexible learning through dopamine-mediated integration parallel sets DAN/MBON interconnections. hybrid physiologic-anatomic mechanism may be general means ecological regulates other species relying dopaminergic signaling, including vertebrate basal ganglia10.

Язык: Английский

Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior DOI Creative Commons
Taylor Hart,

Dominic D. Frank,

Lindsey E. Lopes

и другие.

Cell, Год журнала: 2023, Номер 186(14), С. 3079 - 3094.e17

Опубликована: Июнь 15, 2023

Ants communicate via large arrays of pheromones and possess expanded, highly complex olfactory systems, with antennal lobes in the brain comprising up to ∼500 glomeruli. This expansion implies that odors could activate hundreds glomeruli, which would pose challenges for higher-order processing. To study this problem, we generated transgenic ants expressing genetically encoded calcium indicator GCaMP sensory neurons. Using two-photon imaging, mapped complete glomerular responses four ant alarm pheromones. Alarm robustly activated ≤6 activity maps three inducing panic our species converged on a single glomerulus. These results demonstrate that, rather than using broadly tuned combinatorial encoding, employ precise, narrowly tuned, stereotyped representations The identification central hub glomerulus behavior suggests simple neural architecture is sufficient translate pheromone perception into behavioral outputs.

Язык: Английский

Процитировано

24
Acute ozone exposure impairs detection of floral odor, learning, and memory of honey bees, through olfactory generalization DOI Creative Commons
Fabien Démares,

Laëtitia Gibert,

Pierre Creusot

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 827, С. 154342 - 154342

Опубликована: Март 5, 2022

Язык: Английский

Процитировано

31
Neonicotinoid effects on tropical bees: Imidacloprid impairs innate appetitive responsiveness, learning and memory in the stingless bee Melipona quadrifasciata DOI
João Marcelo Robazzi Bignelli Valente Aguiar, Roberta Cornélio Ferreira Nocelli, Martín Giurfa

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 877, С. 162859 - 162859

Опубликована: Март 16, 2023

Язык: Английский

Процитировано

20
Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee DOI Creative Commons
Julie Carcaud, Marianne Otte,

Bernd Grünewald

и другие.

PLoS Biology, Год журнала: 2023, Номер 21(1), С. e3001984 - e3001984

Опубликована: Янв. 31, 2023

Understanding of the neural bases for complex behaviors in Hymenoptera insect species has been limited by a lack tools that allow measuring neuronal activity simultaneously different brain regions. Here, we developed first pan-neuronal genetic driver Hymenopteran model organism, honey bee, and expressed calcium indicator GCaMP6f under control bee synapsin promoter. We show is widely brain, allowing to record from multiple To assess power this tool, focused on olfactory system, recording simultaneous responses antennal lobe, more poorly investigated lateral horn (LH) mushroom body (MB) calyces. Neural 16 distinct odorants demonstrate odorant quality (chemical structure) quantity are faithfully encoded lobe. In contrast, odor coding LH departs simple physico-chemical coding, supporting role structure biological value odorants. further robust several pheromone odorants, key drivers social behavior, LH. Combined, these recordings represent use neurogenetic tool large-scale eusocial will be utility assessing underpinnings other sensory modalities cognitive abilities.

Язык: Английский

Процитировано

16
Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances DOI Creative Commons
Ke Li,

Xiasang Chen,

Pingli Dai

и другие.

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 20, 2023

The use of agricultural neonicotinoid insecticides has sub-lethal chronic effects on bees that are more prevalent than acute toxicity. Among these insecticides, thiacloprid, a commonly used compound with low toxicity, attracted significant attention due to its potential impact the olfactory and learning abilities honeybees. effect larval exposure thiacloprid antennal activity adult honeybees ( Apis mellifera L.) is not yet fully understood. To address this knowledge gap, laboratory-based experiments were conducted in which honeybee larvae administered (0.5 mg/L 1.0 mg/L). Using electroantennography (EAG), impacts selectivity common floral volatiles evaluated. Additionally, odor-related memory also assessed. results study reveal, for first time, decreased antenna EAG responses scents, leading increased high-dose (1.0 mg/L) group compared control (0 vs . mg/L: p = 0.042). suggest negatively affected odor-associated paired acquisition, as well medium-term (1 h) 0.019) long-term (24 0.037) amplitudes dramatically reduced following R-linalool training 0.001; 0 0.5 0.027), while activities only differed significantly between unpaired groups. Our indicated concentrations may affect perception behaviors These findings have important implications safe agrochemicals environment.

Язык: Английский

Процитировано

14
Precision detection of select human lung cancer biomarkers and cell lines using honeybee olfactory neural circuitry as a novel gas sensor DOI

Michael Parnas,

Autumn K. McLane-Svoboda,

Elyssa Cox

и другие.

Biosensors and Bioelectronics, Год журнала: 2024, Номер 261, С. 116466 - 116466

Опубликована: Июнь 4, 2024

Язык: Английский

Процитировано

6
Peripheral taste detection in honey bees: What do taste receptors respond to? DOI
Louise Bestea, Alexandre Réjaud, Jean‐Christophe Sandoz

и другие.

European Journal of Neuroscience, Год журнала: 2021, Номер 54(2), С. 4417 - 4444

Опубликована: Май 2, 2021

Abstract Understanding the neural principles governing taste perception in species that bear economic importance or serve as research models for other sensory modalities constitutes a strategic goal. Such is case of honey bee ( Apis mellifera ), which environmentally and socioeconomically important, given its crucial role pollinator agent agricultural landscapes has served traditional model visual olfactory neurosciences on communication, navigation, learning memory. Here we review current knowledge gustatory receptors to provide an integrative view peripheral detection this insect, highlighting specificities commonalities with insect species. We describe behavioral electrophysiological responses several tastant categories relate these responses, whenever possible, known molecular receptor mechanisms. Overall, adopted evolutionary comparative perspective understand define key questions should be answered future centered insect.

Язык: Английский

Процитировано

31
The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect DOI Creative Commons
Louise Bestea, Marco Paoli, Patrick Arrufat

и другие.

iScience, Год журнала: 2021, Номер 25(1), С. 103619 - 103619

Опубликована: Дек. 11, 2021

The neuropeptide F (NPF) and its short version (sNPF) mediate food- stress-related responses in solitary insects. In the honeybee, a social insect where food collection defensive are socially regulated, only sNPF has an identified receptor. Here we increased artificially levels honeybee foragers studied consequences of this manipulation various forms appetitive aversive responsiveness. Increasing partially fed bees turned them into equivalent starved animals, enhancing both their consumption responsiveness to gustatory olfactory stimuli. Neural activity circuits animals was reduced could be rescued by treatment level bees. contrast, had no effect on nociceptive Our results thus identify as key modulator hunger food-related bees, which at core foraging activities.

Язык: Английский

Процитировано

28
Transient active zone remodeling in the Drosophila mushroom body supports memory DOI Creative Commons
Oriane Turrel, Niraja Ramesh, Marc Escher

и другие.

Current Biology, Год журнала: 2022, Номер 32(22), С. 4900 - 4913.e4

Опубликована: Ноя. 1, 2022

Язык: Английский

Процитировано

21
The neuroecology of olfaction in bees DOI Creative Commons

Wendy Carolina Gomez Ramirez,

Nyasha KT Thomas,

Iman J Muktar

и другие.

Current Opinion in Insect Science, Год журнала: 2023, Номер 56, С. 101018 - 101018

Опубликована: Фев. 25, 2023

The focus of bee neuroscience has for a long time been on only handful social honeybee and bumblebee species, out thousands bees species that have described. On the other hand, information about chemical ecology is much more abundant. Here we attempted to compile scarce olfactory systems across species. We also review major categories intra- inter-specific behaviors bees, with specific recent literature. finish by discussing most promising avenues research in near future.

Язык: Английский

Процитировано

12