Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

BMC Medical Research Methodology, Год журнала: 2022, Номер 22(1)

Опубликована: Янв. 22, 2022

Abstract Background Longitudinal observational cohort studies in cancer patients are important to move research and clinical practice forward. Continued study participation (study retention) is of importance maintain the statistical power facilitate representativeness findings. This aimed investigate retention attrition (drop-out) its associated sociodemographic factors among head neck (HNC) informal caregivers included Netherlands Quality Life Biomedical Cohort Study (NET-QUBIC). Methods NET-QUBIC a longitudinal 739 HNC 262 with collection patient-reported outcome measures (PROMs), fieldwork data (interview, objective tests medical examination) biobank materials. was described from baseline (before treatment) up 2-years follow-up (after treatment). Sociodemographic characteristics components at (PROMs, samples) general (participation least one component) were investigated using Chi-square, Fisher exact or independent t-tests ( p < 0.05). Results 80% alive (66% all patients) 70% who participating (52% caregivers). Attrition most often caused by mortality, logistic, physical, psychological-related reasons. Tumor stage I/II, better physical performance (lower) comorbidity score PROMs component patients. No (patients), overall sample (patients caregivers) (caregivers) identified. A (among higher age follow-up. Conclusions Retention rates high two years (i.e. an active patient). Nevertheless, some selection shown terms tumor stage, performance, age, which might limit samples. To findings future benefit oversampling specific subgroups, such as poor outcomes younger caregivers.

Язык: Английский

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The association between sleep problems and general quality of life in cancer patients and in the general population

Frontiers in Psychology, Год журнала: 2022, Номер 13

Опубликована: Дек. 15, 2022

It is well-known that patients with cancer frequently experience sleep problems, and quality associated general of life (QoL). The aims this study were to analyze the relationship between problems other components QoL in more detail investigate sex age differences comparison population.This comprised one population sample (n = 4,476) eight samples 323 4,020). Sleep Quality was measured using questionnaire EORTC QLQ-C30.All patient groups reported than population. all facets both highest associations found for fatigue (r 0.52) emotional functioning -0.47). association lower -0.37) -0.46). Female markedly male did (d 0.45), while difference 0.15). In contrast population, younger had greater trouble sleeping older -0.17).The results underline significance role mental factors play problems. Health care providers should pay special attention female concerning issue.

Язык: Английский

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Association of Insomnia and Obstructive Sleep Apnea with Worse Oral Mucositis and Quality of Life in Head and Neck Cancer Patients Undergoing Radiation Therapy

Cancers, Год журнала: 2024, Номер 16(7), С. 1335 - 1335

Опубликована: Март 29, 2024

Background: Patients with head and neck cancer (HNC) undergoing radiation therapy (RT) often experience sleep disturbances that may contribute to oral mucositis (OM) quality of life (QOL). Methods: HNC treated RT at a single institution were examined. Sleep questionnaires given on the first day assess for insomnia obstructive apnea (OSA). Patient-reported QOL assessed during RT. Associations between OSA using Mann–Whitney U test. Linear mixed models associations OM. Results: Among 87 patients, 34 patients (39%) had subthreshold or greater 47 (54%) screened positive OSA. Upon completion, worse physical function (p = 0.005), fatigue 0.01), < 0.001), sticky saliva 0.002). screening 0.02), 0.007), 0.009), pain 0.005). linear model evaluation, 0.01) screen 0.002) associated Conclusion: Insomnia are highly prevalent in These OM treatment.

Язык: Английский

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The Association between Sleep Quality and Fatigue in Colorectal Cancer Survivors up until Two Years after Treatment: A Cross-Sectional and Longitudinal Analysis

Cancers, Год журнала: 2022, Номер 14(6), С. 1527 - 1527

Опубликована: Март 16, 2022

Fatigue is a distressing complaint with high detriment to quality of life that persists in one-third colorectal cancer survivors after treatment. Previous studies mixed groups patients have suggested sleep associated fatigue. We aimed investigate this association up until two years post-treatment. Data on n = 388 stage I-III were utilized from the EnCoRe study. Sleep and fatigue measured at 6 weeks 6, 12, 24 months was using Pittsburgh Quality Index (cross-sectional analysis only) single-item insomnia scale EORTC QLQ-C30. by Checklist Individual Strength. Linear mixed-model regression analyses analysed associations between cross-sectionally longitudinally. Longitudinal revealed worsening over time significantly increased levels (β per 0.5 SD increase EORTC-insomnia score 2.56, 95% Cl: 1.91, 3.22). Significant cross-sectional observed worse higher all points. Worse during first

Язык: Английский

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Psychoneurological Symptoms and Biomarkers of Stress and Inflammation in Newly Diagnosed Head and Neck Cancer Patients: A Network Analysis

Current Oncology, Год журнала: 2022, Номер 29(10), С. 7109 - 7121

Опубликована: Сен. 28, 2022

Psychoneurological symptoms are commonly reported by newly diagnosed head and neck cancer (HNC) patients, yet there is limited research on the associations of these with biomarkers stress inflammation. In this article, pre-treatment data a multi-center cohort HNC patients were analyzed using network analysis to examine connections between (poor sleep quality, anxiety, depression, fatigue, oral pain), (diurnal cortisol slope), inflammation markers (c-reactive protein [CRP], interleukin [IL]-6, IL-10, tumor necrosis factor alpha [TNF-α]), covariates (age body mass index [BMI]). Three centrality indices calculated: degree (number connections), closeness (proximity variable other variables), betweenness (based number times located shortest path any pair variables). sample 264 poor quality fatigue had highest index; CRP IL-6 index. The model yielded two clusters: symptoms—cortisol slope—CRP cluster IL-6—IL-10—TNF-α—age—BMI cluster. Both clusters connected most prominently via IL-6. Our findings provide evidence that CRP, play an important role in interconnections psychoneurological patients.

Язык: Английский

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Sleep Quality and Associated Factors Among Adult Cancer Patients Under Treatment at Oncology Units in Amhara Region, Ethiopia

Nature and Science of Sleep, Год журнала: 2022, Номер Volume 14, С. 1049 - 1062

Опубликована: Июнь 1, 2022

Poor sleep quality, a common, under-diagnosed, and under-treated problem in cancer patients, has negative physical psychological consequences, but its prevalence associated factors are not well studied Ethiopia. Thus, the present study aimed to assess of quality among adult patients receiving treatment at oncology units Amhara region, Ethiopia.An institution-based cross-sectional was conducted with under region from April 12 May 12/2021. A systematic random sampling technique used select 423 samples. Data were collected using structured Interviewer-administered questionnaire. Sleep depression assessed by Pittsburgh Quality Index subscale Hospital Anxiety Depression Scale, respectively. Bivariable multivariable logistic regression analyses computed, considering p < 0.25 candidate variables for analysis 0.05 be statistically significant final model.A total 410 participated this study. The mean participant's age 44.2 (range: 20-77) years. More than half (52.7%) participants received chemotherapy remaining treated combination treatments. Two-hundred ninety-three (71.5%) had poor 28.5% good quality. found significantly advanced [AOR = 1.037, 95% CI: (1.012-1.062)]; having depressive symptoms 2.862, (1.133, 7.228)]; distant metastasis 3.758, (1.585, 8.909)]; increased severity pain 1.331, (1.106, 1.601)].The high patients. Early screening management problems crucial cancer.

Язык: Английский

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Sleep quality trajectories from head and neck cancer diagnosis to six months after treatment

Oral Oncology, Год журнала: 2021, Номер 115, С. 105211 - 105211

Опубликована: Фев. 15, 2021

Patients with head and neck cancer (HNC) often report disturbances in their sleep quality, impairing quality of life. This study aims to examine the trajectories from diagnosis up 6-month after treatment, as well pre-treatment risk factors for poor trajectories.Sleep (Pittsburgh index) was measured shortly (pre-treatment), at 3 6 months finishing treatment. were categorized into 5 trajectory groups. We examined association sociodemographic clinical characteristics, coping style, HNC symptoms, psychological distress.Among 412 included patients, about a half either had persistent good (37.6%) or an improving (16.5%) trajectory. About third (21.8%) worsening (10.9%) The remaining patients (13.1%), alternated between sleep. Using reference outcome, sleepers more likely be woman (odds ratio [OR] = 1.98, 95% confidence interval [CI] 1.01-3.90), use painkillers prior treatment (OR 2.52, CI 1.33-4.77), have anxiety symptoms 1.26, 1.15-1.38).Unfavorable are prevalent among A periodic evaluation starting is necessary identify problems, especially high-risk group.

Язык: Английский

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Symptom clusters and quality of life in ambulatory patients with multiple myeloma

Supportive Care in Cancer, Год журнала: 2022, Номер 30(6), С. 4961 - 4970

Опубликована: Фев. 19, 2022

Язык: Английский

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Exercise regimens for improved sleep quality in adult breast cancer survivors: systematic review and network meta-analysis

BMJ Supportive & Palliative Care, Год журнала: 2023, Номер 13(4), С. 393 - 400

Опубликована: Авг. 16, 2023

Objective The relative efficacy of exercise regimens for improving sleep quality in adult breast cancer survivors remains unknown. This network meta-analysis aimed to compare the various survivors. Methods study searched four electronic databases relevant literature from inception 18 July 2023. Randomised controlled trials reporting effects on adults with were included. A random-effects based frequentist framework was performed. Results In total, 35 including 3374 Compared usual care, endurance training combined resistance significantly improved (standardised mean differences (SMDs) = −0.97; 95% CI −1.50 −0.43; certainty evidence=moderate) (p<0.05). Endurance (SMDs: −1.42; CIs: −2.31 −0.53; moderate) achieved superior results compared stretching exercises surface under cumulative ranking curve analysis indicated that ranked as top effective treatment among other (71%). Conclusions is Our provide evidence can improve

Язык: Английский

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Demographic, clinical, and sociocognitive determinants related to physical activity and dietary intake in patients with ovarian cancer: A cross-sectional study

Gynecologic Oncology, Год журнала: 2024, Номер 183, С. 39 - 46

Опубликована: Март 18, 2024

To study physical activity and dietary intake among patients with ovarian cancer to examine which demographic, clinical, sociocognitive determinants are associated these behaviours.

Язык: Английский

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