Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review

NeuroImage, Год журнала: 2022, Номер 249, С. 118870 - 118870

Опубликована: Янв. 1, 2022

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced technique that enables in vivo reconstruction of the brain's white matter connections at macro scale. It provides important tool for quantitative mapping structural connectivity using measures or tissue microstructure. Over last two decades, study brain dMRI has played a prominent role neuroimaging research landscape. In this paper, we provide high-level overview how used to enable analysis health and disease. We focus on types analyses tractography, including: 1) tract-specific refers typically hypothesis-driven studies particular anatomical fiber tracts, 2) connectome-based more data-driven generally entire brain. first review methodology involved three main processing steps are common across most approaches including methods correction, segmentation quantification. For each step, aim describe methodological choices, their popularity, potential pros cons. then have matter, focusing applications neurodevelopment, aging, neurological disorders, mental neurosurgery. conclude that, while there been considerable advancements technologies breadth applications, nevertheless remains no consensus about "best" researchers should remain cautious when interpreting results clinical applications.

Язык: Английский

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The complexities underlying epilepsy in people with glioblastoma

The Lancet Neurology, Год журнала: 2023, Номер 22(6), С. 505 - 516

Опубликована: Апрель 27, 2023

Язык: Английский

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White Matter Tracts and Diffuse Lower-Grade Gliomas: The Pivotal Role of Myelin Plasticity in the Tumor Pathogenesis, Infiltration Patterns, Functional Consequences and Therapeutic Management

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Март 2, 2022

For many decades, interactions between diffuse lower-grade glioma (LGG) and brain connectome were neglected. However, the neoplasm progression is intimately linked to its environment, especially white matter (WM) tracts their myelin status. First, while etiopathogenesis of LGG unclear, this tumor seems appear during adolescence, it mostly located within anterior associative cerebral areas. Because these structures correspond those which myelinated later in maturation process, WM myelination could play a role development LGG. Second, fibers characteristics also participate diffusion, since cells migrate along subcortical pathways, when exhibiting demyelinated phenotype, may result large invasion parenchyma. Third, such migratory pattern can induce functional (neurological, cognitive behavioral) disturbances, because represent main limitation neuroplastic potential. These parameters are critical for tailoring an individualized therapeutic strategy, both (i) regarding timing active treatment(s) must be proposed earlier, before too wide infiltration bundles, (ii) anatomic extent surgical resection irradiation, should take account connectivity. Therefore, new science connectomics integrated management, based upon improved understanding interplay across dissemination reactional neural networks reconfiguration, order optimize long-term oncological outcomes. To end, mechanisms activity-dependent plasticity better investigated.

Язык: Английский

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The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review

Acta Neurochirurgica, Год журнала: 2022, Номер 164(10), С. 2789 - 2809

Опубликована: Авг. 9, 2022

Язык: Английский

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The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude

Brain Sciences, Год журнала: 2022, Номер 12(4), С. 504 - 504

Опубликована: Апрель 15, 2022

Diffuse low-grade gliomas (DLGGs) are heterogeneous and poorly circumscribed neoplasms with isolated tumor cells that extend beyond the margins of lesion depicted on MRI. Efforts to demarcate glioma core from surrounding healthy brain led us define an intermediate region, so-called peritumoral zone (PTZ). Although most studies about PTZ have been conducted high-grade gliomas, purpose here is review cellular, metabolic, radiological characteristics in specific context DLGG. A better delineation PTZ, which neural tissue strongly interact, may open new therapeutic avenues optimize both functional oncological results. First, a connectome-based “supratotal” surgical resection (i.e., removal addition core) resulted prolonged survival by limiting risk malignant transformation, while improving quality life, thanks control seizures. Second, timing order (neo)adjuvant medical treatments can be modulated according pattern infiltration. Third, development drugs specifically targeting could considered (such as immunotherapy) epileptological perspective. Further multimodal investigations needed maximize long-term outcomes DLGG patients.

Язык: Английский

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Translational Connectomics: overview of machine learning in macroscale Connectomics for clinical insights

BMC Neurology, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 28, 2024

Язык: Английский

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Using machine learning to evaluate large-scale brain networks in patients with brain tumors: Traditional and non-traditional eloquent areas

Neuro-Oncology Advances, Год журнала: 2022, Номер 4(1)

Опубликована: Янв. 1, 2022

Large-scale brain networks and higher cognitive functions are frequently altered in neuro-oncology patients, but comprehensive non-invasive mapping is difficult to achieve the clinical setting. The objective of our study evaluate traditional non-traditional eloquent areas tumor patients using a machine-learning platform.We retrospectively included who underwent surgery for resection at Institution. Preoperative MRI with T1-weighted DTI sequences were uploaded into Quicktome platform. We categorized integrity nine large-scale networks: language, sensorimotor, visual, ventral attention, central executive, default mode, dorsal salience limbic. Network was correlated preoperative data.One-hundred study. most affected network executive (49%), followed by mode (43%) attention (32%). Patients deficits showed significantly number before (3.42 vs 2.19, P < .001), compared without deficits. Furthermore, we found that neurologic had an average 2.19 1.51 at-risk, them being related (P .001).Our results show tumors, even when presenting evident In study, commonly areas. Integrating techniques setting may help elucidate how preserve higher-order associated those networks.

Язык: Английский

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Naso-Ethmoidal Schwannoma: From Pathology to Surgical Strategies

Cancers, Год журнала: 2025, Номер 17(7), С. 1068 - 1068

Опубликована: Март 22, 2025

Background: Naso-ethmoidal schwannoma is a rare slow-growing tumor arising from the Schwann cells of sinonasal tract. This study discusses evolution surgical approaches to naso-ethmoidal schwannomas with respect growth and recent advances in minimally invasive techniques. Materials Methods: A comprehensive literature review on Embase online electronic database benign was performed. Demographic, clinical, neuroradiological, pathological, factors were analyzed discussed. Results: Twenty-five cases met inclusion criteria. No predilection for gender evident. The mean age at diagnosis 40.2 years old. Nasal obstruction most common presenting symptom (64%), followed by headache (60%), hypo-anosmia (24%), visual impairment (24%). Skull base orbital involvement registered 64% 16% cases, respectively. Surgery unique curative treatment, endoscopic endonasal approach which plays leading role (44%). Gross total resection possible all associated no recurrence. perioperative complication rate 32% mainly consisted cerebrospinal fluid leakage. time treatment 21 months. All patients alive last follow up. Conclusion: only schwannomas, main goal relief clinical manifestations. route represents master lesions confined midline. Transcranial transorbital play complementary when large intracranial extension occur,

Язык: Английский

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The death of localizationism: The concepts of functional connectome and neuroplasticity deciphered by awake mapping, and their implications for best care of brain-damaged patients

Revue Neurologique, Год журнала: 2021, Номер 177(9), С. 1093 - 1103

Опубликована: Сен. 23, 2021

Язык: Английский

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Augmented surgical decision-making for glioblastoma: integrating AI tools into education and practice

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Июнь 7, 2024

Surgical decision-making for glioblastoma poses significant challenges due to its complexity and variability. This study investigates the potential of artificial intelligence (AI) tools in improving “decision-making processes” surgery. A systematic review literature identified 10 relevant studies, primarily focused on predicting resectability surgery-related neurological outcomes. AI tools, especially rooted radiomics connectomics, exhibited promise resection extent through precise tumor segmentation tumor-network relationships. However, they demonstrated limited effectiveness postoperative dynamic less quantifiable nature patient-related factors. Recognizing these challenges, including datasets interpretability requirement medical applications, underscores need standardization, algorithm optimization, addressing variability model performance then further validation clinical settings. While holds potential, it currently does not possess capacity emulate nuanced process utilized by experienced neurosurgeons comprehensive approach

Язык: Английский

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