Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review

NeuroImage, Journal Year: 2022, Volume and Issue: 249, P. 118870 - 118870

Published: Jan. 1, 2022

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced technique that enables in vivo reconstruction of the brain's white matter connections at macro scale. It provides important tool for quantitative mapping structural connectivity using measures or tissue microstructure. Over last two decades, study brain dMRI has played a prominent role neuroimaging research landscape. In this paper, we provide high-level overview how used to enable analysis health and disease. We focus on types analyses tractography, including: 1) tract-specific refers typically hypothesis-driven studies particular anatomical fiber tracts, 2) connectome-based more data-driven generally entire brain. first review methodology involved three main processing steps are common across most approaches including methods correction, segmentation quantification. For each step, aim describe methodological choices, their popularity, potential pros cons. then have matter, focusing applications neurodevelopment, aging, neurological disorders, mental neurosurgery. conclude that, while there been considerable advancements technologies breadth applications, nevertheless remains no consensus about "best" researchers should remain cautious when interpreting results clinical applications.

Language: Английский

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The complexities underlying epilepsy in people with glioblastoma

The Lancet Neurology, Journal Year: 2023, Volume and Issue: 22(6), P. 505 - 516

Published: April 27, 2023

Language: Английский

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White Matter Tracts and Diffuse Lower-Grade Gliomas: The Pivotal Role of Myelin Plasticity in the Tumor Pathogenesis, Infiltration Patterns, Functional Consequences and Therapeutic Management

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 2, 2022

For many decades, interactions between diffuse lower-grade glioma (LGG) and brain connectome were neglected. However, the neoplasm progression is intimately linked to its environment, especially white matter (WM) tracts their myelin status. First, while etiopathogenesis of LGG unclear, this tumor seems appear during adolescence, it mostly located within anterior associative cerebral areas. Because these structures correspond those which myelinated later in maturation process, WM myelination could play a role development LGG. Second, fibers characteristics also participate diffusion, since cells migrate along subcortical pathways, when exhibiting demyelinated phenotype, may result large invasion parenchyma. Third, such migratory pattern can induce functional (neurological, cognitive behavioral) disturbances, because represent main limitation neuroplastic potential. These parameters are critical for tailoring an individualized therapeutic strategy, both (i) regarding timing active treatment(s) must be proposed earlier, before too wide infiltration bundles, (ii) anatomic extent surgical resection irradiation, should take account connectivity. Therefore, new science connectomics integrated management, based upon improved understanding interplay across dissemination reactional neural networks reconfiguration, order optimize long-term oncological outcomes. To end, mechanisms activity-dependent plasticity better investigated.

Language: Английский

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The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review

Acta Neurochirurgica, Journal Year: 2022, Volume and Issue: 164(10), P. 2789 - 2809

Published: Aug. 9, 2022

Language: Английский

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The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(4), P. 504 - 504

Published: April 15, 2022

Diffuse low-grade gliomas (DLGGs) are heterogeneous and poorly circumscribed neoplasms with isolated tumor cells that extend beyond the margins of lesion depicted on MRI. Efforts to demarcate glioma core from surrounding healthy brain led us define an intermediate region, so-called peritumoral zone (PTZ). Although most studies about PTZ have been conducted high-grade gliomas, purpose here is review cellular, metabolic, radiological characteristics in specific context DLGG. A better delineation PTZ, which neural tissue strongly interact, may open new therapeutic avenues optimize both functional oncological results. First, a connectome-based “supratotal” surgical resection (i.e., removal addition core) resulted prolonged survival by limiting risk malignant transformation, while improving quality life, thanks control seizures. Second, timing order (neo)adjuvant medical treatments can be modulated according pattern infiltration. Third, development drugs specifically targeting could considered (such as immunotherapy) epileptological perspective. Further multimodal investigations needed maximize long-term outcomes DLGG patients.

Language: Английский

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Using machine learning to evaluate large-scale brain networks in patients with brain tumors: Traditional and non-traditional eloquent areas

Neuro-Oncology Advances, Journal Year: 2022, Volume and Issue: 4(1)

Published: Jan. 1, 2022

Large-scale brain networks and higher cognitive functions are frequently altered in neuro-oncology patients, but comprehensive non-invasive mapping is difficult to achieve the clinical setting. The objective of our study evaluate traditional non-traditional eloquent areas tumor patients using a machine-learning platform.We retrospectively included who underwent surgery for resection at Institution. Preoperative MRI with T1-weighted DTI sequences were uploaded into Quicktome platform. We categorized integrity nine large-scale networks: language, sensorimotor, visual, ventral attention, central executive, default mode, dorsal salience limbic. Network was correlated preoperative data.One-hundred study. most affected network executive (49%), followed by mode (43%) attention (32%). Patients deficits showed significantly number before (3.42 vs 2.19, P < .001), compared without deficits. Furthermore, we found that neurologic had an average 2.19 1.51 at-risk, them being related (P .001).Our results show tumors, even when presenting evident In study, commonly areas. Integrating techniques setting may help elucidate how preserve higher-order associated those networks.

Language: Английский

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Translational Connectomics: overview of machine learning in macroscale Connectomics for clinical insights

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 28, 2024

Language: Английский

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Naso-Ethmoidal Schwannoma: From Pathology to Surgical Strategies

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1068 - 1068

Published: March 22, 2025

Background: Naso-ethmoidal schwannoma is a rare slow-growing tumor arising from the Schwann cells of sinonasal tract. This study discusses evolution surgical approaches to naso-ethmoidal schwannomas with respect growth and recent advances in minimally invasive techniques. Materials Methods: A comprehensive literature review on Embase online electronic database benign was performed. Demographic, clinical, neuroradiological, pathological, factors were analyzed discussed. Results: Twenty-five cases met inclusion criteria. No predilection for gender evident. The mean age at diagnosis 40.2 years old. Nasal obstruction most common presenting symptom (64%), followed by headache (60%), hypo-anosmia (24%), visual impairment (24%). Skull base orbital involvement registered 64% 16% cases, respectively. Surgery unique curative treatment, endoscopic endonasal approach which plays leading role (44%). Gross total resection possible all associated no recurrence. perioperative complication rate 32% mainly consisted cerebrospinal fluid leakage. time treatment 21 months. All patients alive last follow up. Conclusion: only schwannomas, main goal relief clinical manifestations. route represents master lesions confined midline. Transcranial transorbital play complementary when large intracranial extension occur,

Language: Английский

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Augmented surgical decision-making for glioblastoma: integrating AI tools into education and practice

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Surgical decision-making for glioblastoma poses significant challenges due to its complexity and variability. This study investigates the potential of artificial intelligence (AI) tools in improving “decision-making processes” surgery. A systematic review literature identified 10 relevant studies, primarily focused on predicting resectability surgery-related neurological outcomes. AI tools, especially rooted radiomics connectomics, exhibited promise resection extent through precise tumor segmentation tumor-network relationships. However, they demonstrated limited effectiveness postoperative dynamic less quantifiable nature patient-related factors. Recognizing these challenges, including datasets interpretability requirement medical applications, underscores need standardization, algorithm optimization, addressing variability model performance then further validation clinical settings. While holds potential, it currently does not possess capacity emulate nuanced process utilized by experienced neurosurgeons comprehensive approach

Language: Английский

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Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8953 - 8953

Published: Aug. 16, 2024

Gliomas present a complex challenge in neuro-oncology, often accompanied by the debilitating complication of epilepsy. Understanding biological interaction and common pathways between gliomagenesis epileptogenesis is crucial for improving current understanding tumorigenesis also developing effective management strategies. Shared genetic molecular mechanisms, such as IDH mutations dysregulated glutamate signaling, contribute to both tumor progression seizure development. Targeting these pathways, through direct inhibition mutant enzymes or modulation receptors, holds promise patient outcomes. Additionally, advancements surgical techniques, like supratotal resection guided connectomics, offer opportunities maximally safe enhanced control. Advanced imaging modalities further aid identifying epileptogenic foci tailoring treatment approaches based on tumor's metabolic characteristics. This review aims explore interplay gliomagenesis, epileptogenesis, neural circuit remodeling, offering insights into shared innovative strategies improve outcomes patients with gliomas associated

Language: Английский

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