Journal of Neural Transmission, Год журнала: 2023, Номер 130(8), С. 1049 - 1056
Опубликована: Март 18, 2023
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 85, С. 101840 - 101840
Опубликована: Янв. 2, 2023
Язык: Английский
Процитировано
63
Journal of Neural Transmission, Год журнала: 2023, Номер 130(10), С. 1207 - 1218
Опубликована: Июль 7, 2023
Язык: Английский
Процитировано
19
Neurochemistry International, Год журнала: 2024, Номер 179, С. 105808 - 105808
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
8
Journal of Neural Transmission, Год журнала: 2024, Номер unknown
Опубликована: Фев. 13, 2024
Язык: Английский
Процитировано
5
Neuropsychiatric Disease and Treatment, Год журнала: 2025, Номер Volume 21, С. 241 - 256
Опубликована: Фев. 1, 2025
Background and Aim: Depression is thought to affect up half of Parkinson's patients at some point during their illness, while anxiety reported by about 40% PD patients. The study aimed assess the prevalence depression among with disease (PD) in Saudi Arabia. Methods: involved Arabian citizens residents aged 40 or older PD, who completed internet-survey (including online email-based data collection) telephone-survey trained interviewers. We used Disease Questionnaire for quality-of-Life assessment questionnaire (PDQ-39), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7). Results: included 46 participants, whom 37% were 60– 69 years, 67% male, 46% had a university education, 87% married. symptoms present 84.8% 73.9% experienced anxiety. lacking social support 8 times more likely develop major [OR = 8.27, 95% CI (1.47– 46.31), p 0.016] 5 experience 5.36, (1.14– 25.26), 0.034]. Those unable perform daily living activities faced stigma 16.5 higher likelihood 16.5, (1.62– 168.48), 0.018]. Furthermore, cognitive impairment increased 11 11.43, (1.83– 71.42), 0.009]. Conclusion: reveals high patients, linked physical impairments isolation. Many report no mental health improvement despite treatment, highlighting need routine assessments, support, tailored interventions enhance quality life. small sample size may limit statistical power, precision, generalizability study's findings. Keywords: Parkinson disease, depression, anxiety, Arabia
Язык: Английский
Процитировано
0
npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)
Опубликована: Март 2, 2025
Abstract Parkinson’s disease is a highly heterogeneous disorder, encompassing complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We aimed to investigate genome-wide DNA methylation networks in post-mortem brain samples test for region-specific association with common Of traits tested, we identify co-methylation module the substantia nigra significant correlation depressive Notably, expression genes annotated loci present within this are found be significantly enriched neuronal subtypes nigra. These findings highlight potential involvement neuronal-specific changes regards symptoms disease.
Язык: Английский
Процитировано
0
Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106872 - 106872
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107717 - 107717
Опубликована: Март 1, 2025
Anxiety and depression are common non-motor symptoms of Parkinson's disease (PD) that significantly affect patients' quality life. In recent years, our understanding PD has advanced through multifaceted studies on the pathological mechanisms associated with anxiety in PD. These classic psychiatric involve complex pathophysiology, both distinct features connections to underlying aetiology Furthermore, co-occurrence blurs boundaries between them. Therefore, a comprehensive summary pathogenic will aid better addressing emergence these This article integrates neuroanatomical, neural projection, neurotransmitter, neuroinflammatory, brain-gut axis, neurotrophic, hypothalamic-pituitary-adrenal genetic perspectives provide description core alterations PD, aiming an up-to-date perspective broader therapeutic prospects for patients suffering from or depression.
Язык: Английский
Процитировано
0
Neuropsychopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0
Journal of Parkinson s Disease, Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Electroretinography has emerged as a promising tool for identifying retinal functional anomalies in major psychiatric and neurodevelopmental disorders, such schizophrenia, depressive disorder, bipolar autism spectrum positioning it potential biomarker of monoaminergic dysfunction. However, despite its potential, electroretinography studies Parkinson's disease (PD) over the past decades have been inconsistent, largely due to variations research methodologies. These limitations diminish hinder association between electrophysiological responses PD neuropathology. To address this challenge, review examines most relevant sources data variability reduced reproducibility aimed at detecting signature characteristic PD. We propose consolidation four key protocol factors five cohort criteria enhance diagnostic accuracy research. As protocols are adapted from their clinical origins purposes, we argue that careful attention must be given electrode type placement, well like age, sex, duration severity, medication intake, conditions, comorbidities selection ensure reproducible results. Suggesting inconsistencies these areas may explain reported results contribute lack consensus on which parameters comprise PD, ultimately offer recommendations improve utility techniques early biomarkers
Язык: Английский
Процитировано
0