American Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 14(6), С. 371 - 390
Опубликована: Янв. 1, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 85, С. 101840 - 101840
Опубликована: Янв. 2, 2023
Язык: Английский
Процитировано
63
Journal of Neural Transmission, Год журнала: 2023, Номер 130(10), С. 1207 - 1218
Опубликована: Июль 7, 2023
Язык: Английский
Процитировано
19
Neurochemistry International, Год журнала: 2024, Номер 179, С. 105808 - 105808
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
8
npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)
Опубликована: Март 2, 2025
Abstract Parkinson’s disease is a highly heterogeneous disorder, encompassing complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We aimed to investigate genome-wide DNA methylation networks in post-mortem brain samples test for region-specific association with common Of traits tested, we identify co-methylation module the substantia nigra significant correlation depressive Notably, expression genes annotated loci present within this are found be significantly enriched neuronal subtypes nigra. These findings highlight potential involvement neuronal-specific changes regards symptoms disease.
Язык: Английский
Процитировано
1
Journal of Neural Transmission, Год журнала: 2024, Номер unknown
Опубликована: Фев. 13, 2024
Язык: Английский
Процитировано
5
Medicina, Год журнала: 2023, Номер 59(6), С. 1138 - 1138
Опубликована: Июнь 13, 2023
Background and Objectives: Parkinson’s disease (PD) is a clinically heterogeneous disorder with poorly understood pathological contributing factors. Depression presents one of the most frequent non-motor PD manifestations, several genetic polymorphisms have been suggested that could affect depression risk in PD. Therefore, this review we collected recent studies addressing role factors development PD, aiming to gain insights into its molecular pathobiology enable future targeted effective treatment strategies. Materials Methods: searched PubMed Scopus databases for peer-reviewed research articles published English (pre-clinical clinical as well relevant reviews meta-analyses) investigating architecture pathophysiology depression. Results: particular, genes related serotoninergic pathway (sodium-dependent serotonin transporter gene, SLC6A4, tryptophan hydrolase-2 TPH2), dopamine metabolism neurotransmission (dopamine receptor D3 DRD3, aldehyde dehydrogenase 2 ALDH2), neurotrophic (brain-derived factor BDNF), endocannabinoid system (cannabinoid CNR1), circadian rhythm (thyrotroph embryonic TEF), sodium-dependent neutral amino acid B(0)AT2 SLC6A15), PARK16 locus were detected altering susceptibility among patients. However, gene (SLC6A3), monoamine oxidase A (MAOA) B (MAOB) genes, catechol-O-methyltransferase (COMT), CRY1, CRY2 not Conclusions: specific mechanisms underlying potential diversity are still under investigation, however, there evidence they may involve neurotransmitter imbalance, mitochondrial impairment, oxidative stress, neuroinflammation, dysregulation their downstream signaling pathways.
Язык: Английский
Процитировано
9
Neuropsychiatric Disease and Treatment, Год журнала: 2025, Номер Volume 21, С. 241 - 256
Опубликована: Фев. 1, 2025
Background and Aim: Depression is thought to affect up half of Parkinson's patients at some point during their illness, while anxiety reported by about 40% PD patients. The study aimed assess the prevalence depression among with disease (PD) in Saudi Arabia. Methods: involved Arabian citizens residents aged 40 or older PD, who completed internet-survey (including online email-based data collection) telephone-survey trained interviewers. We used Disease Questionnaire for quality-of-Life assessment questionnaire (PDQ-39), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7). Results: included 46 participants, whom 37% were 60– 69 years, 67% male, 46% had a university education, 87% married. symptoms present 84.8% 73.9% experienced anxiety. lacking social support 8 times more likely develop major [OR = 8.27, 95% CI (1.47– 46.31), p 0.016] 5 experience 5.36, (1.14– 25.26), 0.034]. Those unable perform daily living activities faced stigma 16.5 higher likelihood 16.5, (1.62– 168.48), 0.018]. Furthermore, cognitive impairment increased 11 11.43, (1.83– 71.42), 0.009]. Conclusion: reveals high patients, linked physical impairments isolation. Many report no mental health improvement despite treatment, highlighting need routine assessments, support, tailored interventions enhance quality life. small sample size may limit statistical power, precision, generalizability study's findings. Keywords: Parkinson disease, depression, anxiety, Arabia
Язык: Английский
Процитировано
0
Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106872 - 106872
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107717 - 107717
Опубликована: Март 1, 2025
Anxiety and depression are common non-motor symptoms of Parkinson's disease (PD) that significantly affect patients' quality life. In recent years, our understanding PD has advanced through multifaceted studies on the pathological mechanisms associated with anxiety in PD. These classic psychiatric involve complex pathophysiology, both distinct features connections to underlying aetiology Furthermore, co-occurrence blurs boundaries between them. Therefore, a comprehensive summary pathogenic will aid better addressing emergence these This article integrates neuroanatomical, neural projection, neurotransmitter, neuroinflammatory, brain-gut axis, neurotrophic, hypothalamic-pituitary-adrenal genetic perspectives provide description core alterations PD, aiming an up-to-date perspective broader therapeutic prospects for patients suffering from or depression.
Язык: Английский
Процитировано
0
Neuropsychopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0