Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(14), P. 1525 - 1525
Published: July 15, 2024
The
diagnosis
of
oral
lichen
planus
(OLP)
poses
many
challenges
due
to
its
nonspecific
clinical
symptoms
and
histopathological
features.
Therefore,
the
diagnostic
process
should
include
a
thorough
history,
immunological
tests,
histopathology.
Our
study
aimed
enhance
accuracy
OLP
by
integrating
direct
immunofluorescence
(DIF)
results
with
data
develop
multivariate
predictive
model
based
on
Artificial
Neural
Network.
Eighty
patients
were
assessed
using
DIF
for
various
markers
(immunoglobulins
classes
G,
A,
M;
complement
3;
fibrinogen
type
1
2)
characteristics
such
as
age,
gender,
lesion
location.
Statistical
analysis
was
performed
machine
learning
techniques
in
Statistica
13.
following
variables
assessed:
age
day
onset,
immunofluorescence,
location
white
patches,
locations
erosions,
treatment
medications
dietary
supplement
intake,
dental
status,
smoking
flossing,
mouthwash.
Four
statistically
significant
selected
after
initial
assessment.
final
model,
neural
networks,
achieved
85%
testing
sample
71%
validation
sample.
Significant
predictors
included
stress
at
patches
under
tongue,
erosions
mandibular
gingiva.
In
conclusion,
while
shows
promise,
larger
datasets
more
comprehensive
are
needed
improve
OLP,
highlighting
need
further
research
collaborative
collection
efforts.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 3038 - 3038
Published: Feb. 3, 2023
Lichen
planus
is
a
chronic
disease
affecting
the
skin,
appendages,
and
mucous
membranes.
A
cutaneous
lichen
rare
occurring
in
less
than
1%
of
general
population,
while
oral
illness
up
to
five
times
more
prevalent;
still,
both
forms
equally
impair
patient’s
quality
life.
The
etiology
not
entirely
understood.
Yet,
immune-mediated
mechanisms
have
been
recognized
since
environmental
factors
such
as
hepatitis
virus
infection,
mechanical
trauma,
psychological
stress,
or
microbiome
changes
can
trigger
genetically
susceptible
individuals.
According
current
understanding,
immunopathogenesis
caused
by
cell-mediated
cytotoxicity,
particularly
cytotoxic
T
lymphocytes,
whose
activity
further
influenced
Th1
IL-23/Th-17
axis.
However,
other
immunocytes
inflammatory
pathways
complement
these
mechanisms.
This
paper
presents
comprehensive
insight
into
actual
knowledge
about
planus,
with
causal
genetic
being
discussed,
described,
principal
effectors
its
circuits
identified.
Oral Diseases,
Journal Year:
2022,
Volume and Issue:
29(4), P. 1382 - 1394
Published: Jan. 9, 2022
Abstract
Objectives
The
association
of
OLP
with
other
autoimmune
processes
points
to
the
possibility
that
OLP‐affected
patients
are
actually
developing
an
status
predisposes
them
autoaggression
against
different
targets.
This
systematic
review
and
meta‐analysis
aim
evaluate
current
evidence
on
prevalence
disorders
in
their
magnitude
association.
Methods
We
searched
PubMed,
Embase,
Web
Science,
Scopus
databases
for
studies
published
before
May
2021,
no
limitation
regards
publication
date
or
language.
evaluated
quality
studies,
carried
out
meta‐analyses
performed
heterogeneity,
subgroups,
meta‐regression,
small‐study
effects
analyses.
Results
Inclusion
criteria
were
met
by
153
(23,327
patients).
Our
results
indicate
existence
high
a
frequent
between
some
disorders,
especially
thyroid
disease
(PP
=
7.96%,
95%
CI
6.32–9.75;
OR
1.99,
1.60–2.49,
p
<
0.001)
diabetes
mellitus
9.41%,95%
8.16–10.74;
1.64,
1.34–2.00,
0.001).
Conclusions
study
demonstrates
comorbidity
diseases
as
well
respectively.
Quality
should
be
upgraded
(fibromyalgia,
gastrointestinal
rheumatic
diseases,
Sjogren's
syndrome,
lupus
erythematosus,
dermatological
diseases)
which
data
do
not
allow
us
know
whether
they
really
associated
OLP.
Oral Diseases,
Journal Year:
2022,
Volume and Issue:
29(7), P. 2624 - 2637
Published: Nov. 13, 2022
Recent
new
terminologies
have
been
proposed
for
lesions
in
the
sphere
of
oral
lichen
planus
(OLP)
that
theoretically
present
unique
aetiological,
clinical,
prognostic
or
management
characteristics
different
from
those
so-called
typical
forms
OLP.
We
aimed
to
critically
analyse
what
concepts
and
related
OLP
should
we
accept
based
on
available
evidence.
A
review
literature
was
carried
out
order
New
include
lichenoid
lesions;
contact
reactions,
drug
reactions
context
graft-versus-host
disease;
chronic
ulcerative
stomatitis;
pemphigoid;
some
are
difficult
categorise,
such
as
with
features
proliferative
verrucous
leukoplakia
upper
labial
mucosa.
multidisciplinary,
multicontinent
working
group
has
recently
published
a
guideline
recommendations
modifying
definitions
associated
disease,
among
which
reasoned,
evidence-based
justification
change
is
considered
essential.
An
in-depth
analysis
newly
terms
OLP-related
shows
many
them
not
justified.
In
this
paper,
set
our
position
basis
existing
evidence
appropriateness
use
these
terms.
World Journal of Gastroenterology,
Journal Year:
2022,
Volume and Issue:
28(41), P. 5893 - 5909
Published: Oct. 31, 2022
Lichen
planus
(LP)
is
a
frequent,
chronic
inflammatory
disease
involving
the
skin,
mucous
membranes
and/or
skin
appendages.
Esophageal
involvement
in
lichen
(ELP)
clinically
important
albeit
underdiagnosed
condition.
This
narrative
review
aims
to
give
an
overview
of
current
knowledge
on
ELP,
its
prevalence,
pathogenesis,
clinical
manifestation,
diagnostic
criteria,
and
therapeutic
options
order
provide
support
management.
Studies
ELP
were
collected
using
PubMed/Medline.
Relevant
therapeutical
characteristics
from
published
patient
cohorts
including
our
own
cohort
extracted
summarized.
mainly
affects
middle-aged
women.
The
principal
symptom
dysphagia.
However,
asymptomatic
cases
despite
progressed
macroscopic
esophageal
lesions
may
occur.
pathogenesis
unknown,
however
immune-mediated
mechanism
probable.
Endoscopically,
characterized
by
mucosal
denudation
tearing,
trachealization,
hyperkeratosis.
Scarring
stenosis
occur
courses.
Histologic
findings
include
detachment,
T-lymphocytic
infiltrations,
epithelial
apoptosis
(Civatte
bodies),
dyskeratosis,
Direct
immuno-fluorescence
shows
fibrinogen
deposits
along
basement
membrane
zone.
To
date,
there
no
established
therapy.
treatment
with
topical
steroids
induces
symptomatic
histologic
improvement
two
thirds
patients
general.
More
severe
require
therapy
immunosuppressors.
In
stenosis,
endoscopic
dilation
be
necessary.
regarded
as
precancerous
condition
transition
squamous
cell
carcinoma
has
been
documented
literature.
yet
differential
diagnosis
for
unclear
dysphagia
or
esophagitis.
Timely
might
prevent
potential
sequelae
such
development
invasive
carcinoma.
Further
studies
are
needed
gain
more
about
options.
Medicina oral, patología oral y cirugía bucal,
Journal Year:
2023,
Volume and Issue:
unknown, P. e229 - e237
Published: Jan. 1, 2023
Background:
Oral
lichen
planus
(OLP)
is
a
prevalent
autoimmune
chronic
inflammatory
disease
of
unknown
etiology.The
importance
the
association
between
hepatic
and
OLP
lies
in
fact
that
many
these
disorders
(HC,
HB,
cirrhosis,
steatosis)
behave
as
risk
factors
for
hepatocellular
carcinoma.Material
Methods:
We
searched
PubMed,
Embase,
Web
Science,
Scopus
studies
published
before
January
2022.We
evaluated
quality
(Joanna
Briggs
Institute
tool).We
performed
meta-analyses,
investigated
heterogeneity
studies,
we
also
carried
out
subgroups,
meta-regression,
smallstudy
effects
analyses.146
(21,187
patients)
were
included
this
study.Our
study
aims
to
evaluate
current
evidence
on
prevalence
magnitude
diseases
(especially
those
with
malignancy),
carcinoma
OLP.Results:
Our
results
suggest
patients
present
significant
tendency
development
hepatitis
B
(OR=1.62,
95%CI=1.01-2.40,p=0.02),
C
(OR=4.09,
95%CI=2.77-6.03,p<0.001),
cirrhosis
(OR=5.58,95%CI=1.83-16.96,p=0.002),
steatosis
(OR=5.71,95%CI=0.97-33.60,p=0.05)
(OR=3.10,95%CI=1.14-8.43,p=0.03).Conclusions:
Patients
should
be
rule
presence
disease,
which
can
lead
carcinoma,
allowing
an
early
diagnosis
would
help
better
approach
liver
notable
improvement
prognosis
terms
both
progression
severity.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(11), P. 3224 - 3224
Published: May 30, 2024
Depressive
disorders
are
a
growing
problem
worldwide.
They
also
characterized
by
high
comorbidity,
including
from
the
circle
of
dermatological
diseases.
Autoimmune
diseases
seem
to
be
particularly
correlated
with
depressive
raising
question
their
possible
common
pathomechanism.
The
PubMed
database
was
searched,
focusing
on
results
published
after
2016.
A
particular
reciprocal
correlation
psoriasis,
atopic
dermatitis,
alopecia
areata,
impetigo,
lupus
and
systemic
scleroderma
found.
One
explanation
for
co-occurrence
above
is
that
inflammatory
theory
may
applicable
depression,
various
elements
which
apply
autoimmune
Clinical Oral Investigations,
Journal Year:
2023,
Volume and Issue:
27(6), P. 3057 - 3069
Published: Feb. 14, 2023
Abstract
Objectives
Oral
lichen
planus
with
exclusive
keratotic
reticular,
papular,
and/or
plaque-like
lesions
(K-OLP)
is
a
clinical
pattern
of
OLP
that
may
be
associated
complex
symptomatology
and
psychological
alteration.
The
aim
the
study
was
to
evaluate
prevalence
anxiety
(A)
depression
(D)
in
patients
K-OLP,
analyzing
potential
predictors
which
can
affect
mental
health
status.
Methods
Three
hundred
K-OLP
versus
300
healthy
controls
(HC)
were
recruited
15
Italian
universities.
Numeric
Rating
Scale
(NRS),
Total
Pain
Index
(T-PRI),
Hamilton
Scales
for
Depression
Anxiety
(HAM-D
HAM-A)
administered.
Results
showed
statistically
higher
scores
NRS,
T-PRI,
HAM-D,
HAM-A
compared
HC
(
p
-value
<
0.001
**
).
A
D
found
158
(52.7%)
148
(49.3%)
patients.
Strong
linear
correlations
identified
between
HAM-A,
employment
status
status,
female
gender.
Multivariate
logistic
regression
revealed
HAM-D
greatest
increase
R2
value
patients,
respectively
(DR2
=
55.5%
0.001**;
DR2
56.5%
0.001**).
Conclusions
HC,
also
subjects
without
pain,
suggesting
processing
pain
certain
way
independent
mood.
Clinical
relevance
Mood
disorders
assessment
should
carefully
performed
relation
obtain
complete
analysis
