Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 3, 2023
Abstract
Objectives
This
study
aimed
to
assess
the
periodontal
condition
in
COVID-19
patients
and
determine
multidirectional
association
between
severe
generalized
periodontitis
outcomes.
Materials
Methods
Periodontal
conditions
were
clinically
assessed
214
hospitalized
due
COVID-19,
course
of
disease
was
registered
prospectively
from
hospital
admission.
A
conceptual
model
developed
predict
impact
on
poor
symptomatology,
intensive
care
unit
(ICU)
admission,
death
patients.
The
tested
using
Structure
Equation
Modeling
(SEM)
outcomes
as
affected
by
periodontitis,
when
including
comorbidities,
patient's
age,
smoking
habit
potential
confounding
variables.
Results
Severe
diagnosed
51
(23.8%)
patients,
52
(26.8%)
died
aggravated
COVID-19.
SEM
analysis
revealed
that
positively
associated
with
severe-critical
symptoms
[standard
coefficient
(sc)
=
0.166;
95%CI
0.014–0.319;
p
0.032]
influenced
confounders
(age
smoking).
Significant
associations
observed
pathway
presentation
ICU
admission
(sc
0.995;
0.924–1.065;
<
0.001)
0.512;
0.392–0.631;
0.001].
Conclusions
Findings
suggest
may
play
a
role
aggravation
risks
subsequent
need
for
death.
Clinical
Relevance:
These
results
elucidate
probable
relationship
emphasizing
importance
risk
factor
accentuating
needs
prevention
handle
inhibition
complications.
The Saudi Dental Journal,
Год журнала:
2023,
Номер
35(5), С. 443 - 450
Опубликована: Май 7, 2023
Peri-implantitis
is
an
inflammatory
condition
induced
by
bacterial
biofilm
that
affects
the
soft
and
hard
tissues
surrounding
dental
implants,
compromising
success
of
implant
therapy.
Recent
studies
have
highlighted
potential
links
between
peri-implant
health
systemic
inflammation,
including
uncontrolled
diabetes
mellitus,
psychological
stress,
cardiovascular
disease,
obesity,
infectious
diseases
such
as
COVID-19.
As
peri-implantitis
may
trigger
inflammation
elevating
circulating
levels
pro-inflammatory
cytokines,
which
could
unknown
impacts
on
overall
health.
While
relationship
periodontal
conditions
better
understood,
association
disease
remains
unclear.
Therefore,
this
comprehensive
review
aims
to
summarize
most
recent
evidence
focusing
biological
complications,
microbiology,
biomarkers.
This
enhance
our
understanding
promote
further
research
in
field
discussing
latest
insights
clinical
implications.
Molecular Medicine Reports,
Год журнала:
2024,
Номер
29(3)
Опубликована: Янв. 17, 2024
Periodontitis
is
a
common
chronic
inflammatory
and
destructive
disease
in
the
mouth
considered
to
be
associated
with
systemic
diseases.
Accumulating
evidence
has
suggested
that
periodontitis
risk
factor
for
pulmonary
diseases
such
as
pneumonia,
obstructive
(COPD),
asthma,
coronavirus
2019
(COVID‑19)
lung
cancer.
The
presence
of
periodontal
pathogens
been
detected
samples
from
variety
Periodontal
can
involved
by
promoting
adhesion
invasion
respiratory
pathogens,
regulating
apoptosis
epithelium
inducing
overexpression
mucin
disrupting
balance
immune
systemin
cells.
Additionally,
measures
control
plaque
maintain
health
tissue
decrease
incidence
adverse
events.
This
suggests
close
association
between
present
study
aimed
review
clinical
COPD,
COVID‑19
cancer,
propose
possible
mechanism
potential
role
linking
disease.
could
provide
direction
further
research
on
novel
ideas
diagnosis
treatment
management
these
two
Clinical Oral Investigations,
Год журнала:
2023,
Номер
27(S1), С. 3 - 13
Опубликована: Апрель 20, 2023
Abstract
Objectives
The
objective
of
the
present
narrative
review
was
to
evaluate
evidence
a
possible
association
between
periodontitis
and
COVID-19,
its
biological
plausibility,
using
as
models
potential
associations
with
cardiovascular
diseases,
diabetes,
some
respiratory
diseases.
Methods
A
recent
systematic
used
main
reference
explore
different
including
following
two
focussed
questions:
PECOS
question,
aimed
epidemiological
evidence,
PICOS
designed
derived
from
intervention
studies.
In
addition
that
other
relevant
scientific
documents,
consensus
papers,
were
carefully
selected
appraised.
Findings
Convincing
found
support
plausibility
behind
those
is
based
on
four
factors:
(1)
bacteraemia
oral
bacteria
periodontal
pathogens,
(2)
increased
systemic
inflammation,
(3)
common
genetic
factors,
(4)
environmental
risk
factors.
Limited
initial
available
an
COVID-19
complications.
Among
proposed
factors
explain
suggested
association,
combination
previously
mentioned
plus
additional
related
SARS-CoV-2
characteristics
pathogenicity,
has
been
suggested.
Conclusions
Initial
suggests
may
be
associated
more
severe
higher
death
due
COVID-19.
Clinical
relevance
Due
severity
for
efforts
should
made
improve
health,
promotion
healthy
habits,
such
hygiene.
West Kazakhstan Medical Journal,
Год журнала:
2025,
Номер
67(2), С. 162 - 176
Опубликована: Июнь 2, 2025
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
dysbiotic
oral
microbiome
and
an
altered
immune
response.
It
affects
approximately
10%
of
the
adult
population
one
leading
causes
tooth
loss.
Beyond
its
local
consequences,
periodontitis
closely
associated
with
systemic
diseases,
including
cardiovascular
disorders,
type
2
diabetes,
rheumatoid
arthritis,
osteoporosis,
kidney
disease,
Alzheimer’s
pneumonia,
pregnancy
complications,
COVID-19.
The
main
mechanisms
underlying
this
relationship
include
inflammation,
spread
bacteria
their
toxins
through
bloodstream,
activation
cells
capable
exacerbating
inflammation
in
other
organs.
For
instance,
bacterial
lipopolysaccharides
(LPS)
periodontopathogens
such
as
Porphyromonas
gingivalis
can
contribute
to
development
atherosclerosis,
endotoxemia,
autoimmune
reactions.
Further
clinical
studies
are
required
establish
causal
develop
effective
treatment
strategies.
A
deeper
understanding
these
may
facilitate
interdisciplinary
approaches
prevention
both
related
diseases.
Abstract
Background
A
possible
relationship
between
periodontitis
(PD)
and
COVID-19
its
adverse
outcomes
has
been
suggested.
Hence,
the
present
systematic
review
meta-analysis
aimed
to
investigate
available
evidence
regarding
potential
association
outcomes.
Materials
methods
PubMed,
Scopus,
Web
of
Science,
Google
Scholar
were
searched
for
relevant
studies
published
up
April
15
th
,
2023.
Studies
that
evaluated
PD
included.
Risk
bias
was
by
two
reviewers,
meta-analyses
performed
using
RevMan
5.3
software.
Results
total
22
involving
92,535
patients
from
USA,
Europe,
Asia,
Middle
East
South
America
included;
these,
12
pooled
into
meta-analysis.
Most
(19
studies)
reported
a
significant
COVID-19.
The
data
found
outcomes:
more
severe
symptoms
(OR
=
6.95,
P
0.0008),
ICU
admissions
3.15,
0.0001),
mortality
1.92,
0.21).
Additionally,
compared
mild
PD,
significantly
associated
with
higher
risks
(
0.02);
admission
0.0001);
rates
0.0001).
results
also
revealed
58%
risk
infection
in
0.00001).
Conclusions
findings
suggest
poor
periodontal
health
However,
owing
observed
methodological
heterogeneity
across
included
studies,
further
prospective
cohort
standardized
methodologies
are
warranted
unravel
disease
Dental Journal (Majalah Kedokteran Gigi),
Год журнала:
2024,
Номер
57(1), С. 50 - 55
Опубликована: Фев. 2, 2024
Background:
Previous
research
studies
have
found
the
persistence
of
various
COVID-19
symptoms
even
after
patient
tested
negative
on
a
PCR
test;
this
incident
is
now
known
as
long
COVID.
These
COVID
are
reported
to
appear
in
oral
cavity
including
effects
periodontal
disease,
both
and
disease
release
similar
proinflammatory
cytokines
such
Acute
phase
proteins,
CRP,
TNF-α,
IL-1β,
IL-2,
IL-6,
IFN-g.
Purpose:
This
study
aims
show
periodontal-disease
severity-frequency
distribution
survivors
with
non-COVID-19
patients.
Methods:
Patients’
secondary
data
Periodontics
Clinic
Faculty
Dentistry
at
Trisakti
University
Dental
Hospital
(n=40)
consisted
20
samples
from
who
experienced
group
selected
according
inclusion
criteria.
Afterward,
was
recapitulated
processed
into
report.
Results:
The
percentage
generalized
gingivitis
highest
patients,
while
periodontitis
Based
staging
grading
methods,
it
not
proven
that
increases
severity
periodontitis.
Conclusion:
shows
has
increased.
Meanwhile,
general
increased
However,
there
no
based
method
World Journal of Virology,
Год журнала:
2024,
Номер
13(4)
Опубликована: Окт. 18, 2024
Periodontitis
is
the
inflammation
of
supporting
structures
around
dentition.
Several
microbial
agents,
mostly
bacteria,
have
been
identified
as
causative
factors
for
periodontal
disease.
On
other
hand,
oral
cavity
a
rich
reservoir
viruses
since
it
contains
wide
variety
cell
types
that
can
be
targeted
by
viruses.
Traditionally,
focus
research
about
flora
has
on
bacteria
because
most
widespread
diseases,
like
periodontitis
and
dental
caries,
are
outcomes
bacterial
infection.
However,
recently
especially
after
emergence
coronavirus
disease
2019,
there
growing
tendency
toward
including
also
into
scope
microbiome
investigations.
The
global
high
prevalence
viral
infections
may
point
out
to
concomitant
or
synergistic
effect
between
two.
Although
exact
nature
mechanism
still
not
clearly
understood,
this
could
speculated
through
manipulation
immune
system
viruses;
hence
facilitating
furthermore
colonization
tissues
bacteria.
This
review
provides
an
extensive
detailed
update
role
common
herpes
family
(herpes
simplex,
varicella-zoster,
Epstein-Barr,
cytomegalovirus),
Human
papillomaviruses,
immunodeficiency
virus
severe
acute
respiratory
syndrome
2
in
initiation,
progression
prognosis
periodontitis.
Current Oral Health Reports,
Год журнала:
2023,
Номер
10(4), С. 163 - 174
Опубликована: Ноя. 3, 2023
Abstract
Purpose
of
Review
In
recent
years,
much
attention
has
focused
on
the
role
poor
oral
health
in
development
or
worsening
systemic
diseases,
including
COVID-19.
The
mouth
is
an
important
site
cellular
infection
early
disease
course
We
review
how
pathology,
and
specifically
viral
within
cavity,
may
mediate
severity
duration
particular,
previously
reported
model
SARS-CoV-2
vascular
delivery
from
to
lungs
via
bloodstream
revisited.
Recent
Findings
proposed
that
oral-vascular-pulmonary
route
could
facilitate
severe
lung
This
pathway
also
explain
vital
link
between
periodontitis
COVID-19
severity,
higher
mortality
risk.
pathogenesis
reconsidered
light
findings
regarding
involvement
as
a
reservoir,
pathological
processes
blood,
pulmonary
vasculature,
elsewhere
body.
Oral
dysbiosis
effect
hygiene
mitigating
are
discussed.
evidence
for
persistence
intravascular
passage
rest
body
blood
discussed
context
post-acute
COVID
(long
COVID).
Summary
High
load
status
associated
with
increasing
risk
death.
Pathophysiological
links
activity
mouth,
status,
outcome
provide
rationale
further
evaluation
oral-vascular-systemic
patients
acute
long
COVID.
potential
benefits
protocols
periodontal
procedures
warrant
investigation.
Current Oral Health Reports,
Год журнала:
2024,
Номер
11(1), С. 1 - 7
Опубликована: Янв. 3, 2024
Abstract
Purpose
of
Review
Periodontitis
has
been
linked
to
various
systemic
diseases
and
conditions.
Given
their
shared
comorbidities,
extensive
research
carried
out
explore
the
link
between
periodontitis
COVID-19.
Recent
Findings
A
growing
body
evidence
suggests
that
could
increase
risk
COVID-19
infection
its
complications.
It
suggested
association
two
be
due
immunological,
coagulation,
genetic,
microbiological
reasons.
The
effect
on
immune
system
expression
receptors
used
by
SARS-CoV2
infect
cells
(transmembrane
protease,
serine
2
[TMPRSS2],
angiotensin-converting
enzyme
[ACE2])
prime
an
exacerbated
reaction
against
virus.
Moreover,
there
is
indicating
also
complications
altering
coagulation
pathways,
periodontal
pathogens
were
identified
in
respiratory
patients
suffering
from
severe
In
addition,
it
was
found
both
share
some
genetic
similarities,
suggesting
through
common
pathways.
Summary
this
review,
we
discuss
above-mentioned
associations
make
case
for
prevention
treatment
avoid
SARS-CoV-2
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Март 27, 2023
Background
Studies
have
highlighted
a
possible
influence
of
gingival
and
periodontal
disease
(PD)
on
COVID-19
risk
severity.
However,
the
evidence
is
based
hospital-based
studies
community-level
data
are
sparse.
Objectives
We
described
epidemiological
pattern
SARS-CoV-2
infection
in
Delhi
evaluated
associations
PD
with
incident
regionally
representative
urban
Indian
population.
Methods
In
prospective
study
nested
within
Centre
for
Cardiometabolic
Risk
Reduction
South-Asia
(CARRS)
study,
participants
clinical
status
available
at
baseline
(2014–16)
(
n
=
1,727)
were
approached
between
October
2021
to
March
2022.
Information
incidence,
testing,
management,
severity
was
collected
as
per
WHO
case
criteria
along
vaccination
status.
Absolute
incidence
computed
by
age,
sex,
oral
health.
Differences
rates
tested
using
log-rank
test.
Poisson
regression
models
used
evaluate
independent
COVID-19,
adjusted
socio-demographic
behavioral
factors,
presence
comorbidity,
medication
use.
Results
Among
1,727
participants,
mean
age
44.0
years,
45.7%
men,
84.5%
had
or
89.4%
received
least
one
dose
vaccine.
Overall,
35%
606)
24%
146/606)
positive.
As
total
number
cases
210,
constituting
12%
The
sex-specific
higher
among
men
older
but
women
aged
>60
years
than
same
age.
rate
did
not
differ
significantly
those
having
healthy
periodontium
(19.1
vs.
16.5/1,000
person-years)
there
no
difference
Conclusion
Gingival
associated
increased
COVID-19.