Peri-implantitis and systemic inflammation: A critical update

The Saudi Dental Journal, Год журнала: 2023, Номер 35(5), С. 443 - 450

Опубликована: Май 7, 2023

Peri-implantitis is an inflammatory condition induced by bacterial biofilm that affects the soft and hard tissues surrounding dental implants, compromising success of implant therapy. Recent studies have highlighted potential links between peri-implant health systemic inflammation, including uncontrolled diabetes mellitus, psychological stress, cardiovascular disease, obesity, infectious diseases such as COVID-19. As peri-implantitis may trigger inflammation elevating circulating levels pro-inflammatory cytokines, which could unknown impacts on overall health. While relationship periodontal conditions better understood, association disease remains unclear. Therefore, this comprehensive review aims to summarize most recent evidence focusing biological complications, microbiology, biomarkers. This enhance our understanding promote further research in field discussing latest insights clinical implications.

Язык: Английский

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Advances in the relationship between periodontopathogens and respiratory diseases (Review)

Molecular Medicine Reports, Год журнала: 2024, Номер 29(3)

Опубликована: Янв. 17, 2024

Periodontitis is a common chronic inflammatory and destructive disease in the mouth considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis risk factor for pulmonary diseases such as pneumonia, obstructive (COPD), asthma, coronavirus 2019 (COVID‑19) lung cancer. The presence of periodontal pathogens been detected samples from variety Periodontal can involved by promoting adhesion invasion respiratory pathogens, regulating apoptosis epithelium inducing overexpression mucin disrupting balance immune systemin cells. Additionally, measures control plaque maintain health tissue decrease incidence adverse events. This suggests close association between present study aimed review clinical COPD, COVID‑19 cancer, propose possible mechanism potential role linking disease. could provide direction further research on novel ideas diagnosis treatment management these two

Язык: Английский

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Oral and systemic health: is there a “new” link with COVID-19?

Clinical Oral Investigations, Год журнала: 2023, Номер 27(S1), С. 3 - 13

Опубликована: Апрель 20, 2023

Abstract Objectives The objective of the present narrative review was to evaluate evidence a possible association between periodontitis and COVID-19, its biological plausibility, using as models potential associations with cardiovascular diseases, diabetes, some respiratory diseases. Methods A recent systematic used main reference explore different including following two focussed questions: PECOS question, aimed epidemiological evidence, PICOS designed derived from intervention studies. In addition that other relevant scientific documents, consensus papers, were carefully selected appraised. Findings Convincing found support plausibility behind those is based on four factors: (1) bacteraemia oral bacteria periodontal pathogens, (2) increased systemic inflammation, (3) common genetic factors, (4) environmental risk factors. Limited initial available an COVID-19 complications. Among proposed factors explain suggested association, combination previously mentioned plus additional related SARS-CoV-2 characteristics pathogenicity, has been suggested. Conclusions Initial suggests may be associated more severe higher death due COVID-19. Clinical relevance Due severity for efforts should made improve health, promotion healthy habits, such hygiene.

Язык: Английский

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Association Mechanisms Between Periodontal Diseases and Systemic Pathology

West Kazakhstan Medical Journal, Год журнала: 2025, Номер 67(2), С. 162 - 176

Опубликована: Июнь 2, 2025

Periodontitis is a chronic inflammatory disease caused by dysbiotic oral microbiome and an altered immune response. It affects approximately 10% of the adult population one leading causes tooth loss. Beyond its local consequences, periodontitis closely associated with systemic diseases, including cardiovascular disorders, type 2 diabetes, rheumatoid arthritis, osteoporosis, kidney disease, Alzheimer’s pneumonia, pregnancy complications, COVID-19. The main mechanisms underlying this relationship include inflammation, spread bacteria their toxins through bloodstream, activation cells capable exacerbating inflammation in other organs. For instance, bacterial lipopolysaccharides (LPS) periodontopathogens such as Porphyromonas gingivalis can contribute to development atherosclerosis, endotoxemia, autoimmune reactions. Further clinical studies are required establish causal develop effective treatment strategies. A deeper understanding these may facilitate interdisciplinary approaches prevention both related diseases.

Язык: Английский

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The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Сен. 9, 2023

Abstract Background A possible relationship between periodontitis (PD) and COVID-19 its adverse outcomes has been suggested. Hence, the present systematic review meta-analysis aimed to investigate available evidence regarding potential association outcomes. Materials methods PubMed, Scopus, Web of Science, Google Scholar were searched for relevant studies published up April 15 th , 2023. Studies that evaluated PD included. Risk bias was by two reviewers, meta-analyses performed using RevMan 5.3 software. Results total 22 involving 92,535 patients from USA, Europe, Asia, Middle East South America included; these, 12 pooled into meta-analysis. Most (19 studies) reported a significant COVID-19. The data found outcomes: more severe symptoms (OR = 6.95, P 0.0008), ICU admissions 3.15, 0.0001), mortality 1.92, 0.21). Additionally, compared mild PD, significantly associated with higher risks ( 0.02); admission 0.0001); rates 0.0001). results also revealed 58% risk infection in 0.00001). Conclusions findings suggest poor periodontal health However, owing observed methodological heterogeneity across included studies, further prospective cohort standardized methodologies are warranted unravel disease

Язык: Английский

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Periodontal disease severity in patients with long COVID and non-COVID-19

Dental Journal (Majalah Kedokteran Gigi), Год журнала: 2024, Номер 57(1), С. 50 - 55

Опубликована: Фев. 2, 2024

Background: Previous research studies have found the persistence of various COVID-19 symptoms even after patient tested negative on a PCR test; this incident is now known as long COVID. These COVID are reported to appear in oral cavity including effects periodontal disease, both and disease release similar proinflammatory cytokines such Acute phase proteins, CRP, TNF-α, IL-1β, IL-2, IL-6, IFN-g. Purpose: This study aims show periodontal-disease severity-frequency distribution survivors with non-COVID-19 patients. Methods: Patients’ secondary data Periodontics Clinic Faculty Dentistry at Trisakti University Dental Hospital (n=40) consisted 20 samples from who experienced group selected according inclusion criteria. Afterward, was recapitulated processed into report. Results: The percentage generalized gingivitis highest patients, while periodontitis Based staging grading methods, it not proven that increases severity periodontitis. Conclusion: shows has increased. Meanwhile, general increased However, there no based method

Язык: Английский

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Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses

World Journal of Virology, Год журнала: 2024, Номер 13(4)

Опубликована: Окт. 18, 2024

Periodontitis is the inflammation of supporting structures around dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On other hand, oral cavity a rich reservoir viruses since it contains wide variety cell types that can be targeted by viruses. Traditionally, focus research about flora has on bacteria because most widespread diseases, like periodontitis and dental caries, are outcomes bacterial infection. However, recently especially after emergence coronavirus disease 2019, there growing tendency toward including also into scope microbiome investigations. The global high prevalence viral infections may point out to concomitant or synergistic effect between two. Although exact nature mechanism still not clearly understood, this could speculated through manipulation immune system viruses; hence facilitating furthermore colonization tissues bacteria. This review provides an extensive detailed update role common herpes family (herpes simplex, varicella-zoster, Epstein-Barr, cytomegalovirus), Human papillomaviruses, immunodeficiency virus severe acute respiratory syndrome 2 in initiation, progression prognosis periodontitis.

Язык: Английский

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The Oral-Vascular-Pulmonary Infection Route: a Pathogenic Mechanism Linking Oral Health Status to Acute and Post-Acute COVID-19

Current Oral Health Reports, Год журнала: 2023, Номер 10(4), С. 163 - 174

Опубликована: Ноя. 3, 2023

Abstract Purpose of Review In recent years, much attention has focused on the role poor oral health in development or worsening systemic diseases, including COVID-19. The mouth is an important site cellular infection early disease course We review how pathology, and specifically viral within cavity, may mediate severity duration particular, previously reported model SARS-CoV-2 vascular delivery from to lungs via bloodstream revisited. Recent Findings proposed that oral-vascular-pulmonary route could facilitate severe lung This pathway also explain vital link between periodontitis COVID-19 severity, higher mortality risk. pathogenesis reconsidered light findings regarding involvement as a reservoir, pathological processes blood, pulmonary vasculature, elsewhere body. Oral dysbiosis effect hygiene mitigating are discussed. evidence for persistence intravascular passage rest body blood discussed context post-acute COVID (long COVID). Summary High load status associated with increasing risk death. Pathophysiological links activity mouth, status, outcome provide rationale further evaluation oral-vascular-systemic patients acute long COVID. potential benefits protocols periodontal procedures warrant investigation.

Язык: Английский

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Association Between Periodontitis and COVID-19

Current Oral Health Reports, Год журнала: 2024, Номер 11(1), С. 1 - 7

Опубликована: Янв. 3, 2024

Abstract Purpose of Review Periodontitis has been linked to various systemic diseases and conditions. Given their shared comorbidities, extensive research carried out explore the link between periodontitis COVID-19. Recent Findings A growing body evidence suggests that could increase risk COVID-19 infection its complications. It suggested association two be due immunological, coagulation, genetic, microbiological reasons. The effect on immune system expression receptors used by SARS-CoV2 infect cells (transmembrane protease, serine 2 [TMPRSS2], angiotensin-converting enzyme [ACE2]) prime an exacerbated reaction against virus. Moreover, there is indicating also complications altering coagulation pathways, periodontal pathogens were identified in respiratory patients suffering from severe In addition, it was found both share some genetic similarities, suggesting through common pathways. Summary this review, we discuss above-mentioned associations make case for prevention treatment avoid SARS-CoV-2

Язык: Английский

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Epidemiological pattern of COVID-19 and its association with periodontal health in an urban Indian cohort

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Март 27, 2023

Background Studies have highlighted a possible influence of gingival and periodontal disease (PD) on COVID-19 risk severity. However, the evidence is based hospital-based studies community-level data are sparse. Objectives We described epidemiological pattern SARS-CoV-2 infection in Delhi evaluated associations PD with incident regionally representative urban Indian population. Methods In prospective study nested within Centre for Cardiometabolic Risk Reduction South-Asia (CARRS) study, participants clinical status available at baseline (2014–16) ( n = 1,727) were approached between October 2021 to March 2022. Information incidence, testing, management, severity was collected as per WHO case criteria along vaccination status. Absolute incidence computed by age, sex, oral health. Differences rates tested using log-rank test. Poisson regression models used evaluate independent COVID-19, adjusted socio-demographic behavioral factors, presence comorbidity, medication use. Results Among 1,727 participants, mean age 44.0 years, 45.7% men, 84.5% had or 89.4% received least one dose vaccine. Overall, 35% 606) 24% 146/606) positive. As total number cases 210, constituting 12% The sex-specific higher among men older but women aged >60 years than same age. rate did not differ significantly those having healthy periodontium (19.1 vs. 16.5/1,000 person-years) there no difference Conclusion Gingival associated increased COVID-19.

Язык: Английский

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