Identification and Validation of IFI44 as a Novel Biomarker for Primary Sjögren’s Syndrome
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 5723 - 5740
Опубликована: Авг. 1, 2024
Primary
Sjögren's
syndrome
(pSS)
is
an
autoimmune
condition
marked
by
lymphocyte
infiltration
in
the
exocrine
glands.
Our
study
aimed
to
identify
a
novel
biomarker
for
pSS
improve
its
diagnosis
and
treatment.
Язык: Английский
Transcriptomic Profiling of Peripheral B Cells in Antibody Positive Sjogren’s Patients Reveals Interferon Signature
Genes,
Год журнала:
2024,
Номер
15(5), С. 628 - 628
Опубликована: Май 15, 2024
Background:
Sjögren’s
disease
(SjD)
is
a
common
systemic
autoimmune
that
affects
mainly
women.
Key
pathologic
features
include
the
infiltration
of
exocrine
glands
by
lymphocytes
and
activation
B
with
production
autoantibodies.
We
aimed
to
analyze
transcriptome
circulating
cells
from
patients
SJD
healthy
controls
decipher
B-cell-specific
contribution
SJD.
Methods:
RNA
peripheral
blood
five
untreated
female
SjD
positive
ANA,
anti-SSA
(both
Ro-52
Ro-60),
anti-SSB
rheumatoid-factor,
was
subjected
whole-transcriptome
sequencing.
A
false
discovery
rate
<
0.1
applied
define
differentially
expressed
genes
(DEG).
Results:
RNA-sequencing
identified
56
up
23
down
DEG.
Hierarchal
clustering
showed
clear
separation
between
two
groups.
Ingenuity
pathway
analysis
revealed
these
may
play
role
in
interferon
signaling,
chronic
mycobacterial
infection,
transformation
myeloproliferative
disorders.
Conclusions:
found
upregulated
expression
type-I
type-II
(IFN)-induced
genes,
as
well
contribute
other
concomitant
conditions,
including
infections
higher
risk
This
adds
insight
into
process
suggests
potential
targets
for
future
functional
prognostic
studies.
Язык: Английский
The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren’s syndrome
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 13, 2024
In
the
pathogenesis
and
progression
of
Sjögren's
syndrome
(SS),
hematopoietic
cells
in
peripheral
circulation,
tissue-resident
immune
cells,
parenchymal
salivary
gland
tissues
(such
as
epithelial
endothelial
fibroblasts,
etc.)
all
play
crucial
roles.
These
diverse
form
intricate
networks
interact
with
each
other,
leading
to
tissue
destruction
persistent
chronic
inflammation,
ultimately
causing
irreversible
damage
glandular
function.
Among
these,
(SGECs)
consistently
hold
a
key
position,
characterized
by
their
functions
expressing
co-stimulatory
antigen-presenting
molecules
secreting
pro-inflammatory
cytokines
chemokines.
Moreover,
SGECs
actively
engage
facilitate
development
specific
pathological
structures
within
gland,
such
lymphoepithelial
lesions
(LELs)
tertiary
lymphoid
(TLSs),
thereby
substantially
elevating
risk
mucosa-associated
(MALT)
lymphoma.
Overall,
are
recognized
for
essential
irreplaceable
contributions
SS.
This
review
article
initially
delves
into
anatomical
composition
subsequently
focusing
on
elucidating
different
derived
from
SGECs,
encompassing
chemokines,
cytokines,
anti-inflammatory
pro-survival
damage-associated
molecular
patterns
(DAMPs),
explore
roles
Язык: Английский