Identification and Validation of IFI44 as a Novel Biomarker for Primary Sjögren’s Syndrome

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5723 - 5740

Published: Aug. 1, 2024

Primary Sjögren's syndrome (pSS) is an autoimmune condition marked by lymphocyte infiltration in the exocrine glands. Our study aimed to identify a novel biomarker for pSS improve its diagnosis and treatment.

Language: Английский

Transcriptomic Profiling of Peripheral B Cells in Antibody Positive Sjogren’s Patients Reveals Interferon Signature

Genes, Journal Year: 2024, Volume and Issue: 15(5), P. 628 - 628

Published: May 15, 2024

Background: Sjögren’s disease (SjD) is a common systemic autoimmune that affects mainly women. Key pathologic features include the infiltration of exocrine glands by lymphocytes and activation B with production autoantibodies. We aimed to analyze transcriptome circulating cells from patients SJD healthy controls decipher B-cell-specific contribution SJD. Methods: RNA peripheral blood five untreated female SjD positive ANA, anti-SSA (both Ro-52 Ro-60), anti-SSB rheumatoid-factor, was subjected whole-transcriptome sequencing. A false discovery rate < 0.1 applied define differentially expressed genes (DEG). Results: RNA-sequencing identified 56 up 23 down DEG. Hierarchal clustering showed clear separation between two groups. Ingenuity pathway analysis revealed these may play role in interferon signaling, chronic mycobacterial infection, transformation myeloproliferative disorders. Conclusions: found upregulated expression type-I type-II (IFN)-induced genes, as well contribute other concomitant conditions, including infections higher risk This adds insight into process suggests potential targets for future functional prognostic studies.

Language: Английский

The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren’s syndrome

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

In the pathogenesis and progression of Sjögren's syndrome (SS), hematopoietic cells in peripheral circulation, tissue-resident immune cells, parenchymal salivary gland tissues (such as epithelial endothelial fibroblasts, etc.) all play crucial roles. These diverse form intricate networks interact with each other, leading to tissue destruction persistent chronic inflammation, ultimately causing irreversible damage glandular function. Among these, (SGECs) consistently hold a key position, characterized by their functions expressing co-stimulatory antigen-presenting molecules secreting pro-inflammatory cytokines chemokines. Moreover, SGECs actively engage facilitate development specific pathological structures within gland, such lymphoepithelial lesions (LELs) tertiary lymphoid (TLSs), thereby substantially elevating risk mucosa-associated (MALT) lymphoma. Overall, are recognized for essential irreplaceable contributions SS. This review article initially delves into anatomical composition subsequently focusing on elucidating different derived from SGECs, encompassing chemokines, cytokines, anti-inflammatory pro-survival damage-associated molecular patterns (DAMPs), explore roles

Language: Английский