Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment DOI Creative Commons
Yang Zhang,

Shuhua Gong,

Xiaofei Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Breast cancer is one of the most prevalent cancers in women globally. Its treatment and prognosis are significantly influenced by tumor microenvironment heterogeneity. Precision therapy enhances efficacy, reduces unwanted side effects, maximizes patients’ survival duration while improving their quality life. Spatial transcriptomics significant importance for precise breast cancer, playing a critical role revealing internal structural differences tumors composition microenvironment. It offers novel perspective studying spatial structure cell interactions within tumors, facilitating more effective personalized treatments cancer. This article will summarize latest findings diagnosis from transcriptomics, focusing on revelation microenvironment, identification new therapeutic targets, enhancement disease diagnostic accuracy, comprehension progression metastasis, assessment drug responses, creation high-resolution maps cells, representation heterogeneity, support clinical decision-making, particularly elucidating immunotherapy correlation with outcomes.

Language: Английский

Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets DOI
Muath Suliman, Raed Obaid Saleh,

M Chandra

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

Citations

2
Exosomes: from basic research to clinical diagnostic and therapeutic applications in cancer DOI Creative Commons
Salomé Araujo‐Abad, José Berná,

Elena Lloret-Lopez

et al.

Cellular Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

8
The mechanism of action and therapeutic potential of tumor-associated macrophages in tumor immune evasion DOI Creative Commons
Kehua Wang, Xu Zhang,

Aiqin Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Tumor-associated macrophages (TAMs) play a multifaceted role in tumor progression. As specialized immune cells, are capable of phagocytosis and digesting foreign substances, as well removing harmful substances including cellular debris cells. Under specific pathological conditions, circulating monocytes can be recruited into the microenvironment differentiate TAMs. Macrophages generally polarized two distinct subpopulations: classically activated (M1) alternatively (M2). TAMs constitute significant proportion mononuclear leukocyte population solid tumors, exhibiting complex dualistic relationship with Substantial evidence indicates that interact facilitating their evasion while promoting invasion metastasis. This review focuses on mechanism regulation response to various macrophage-based tumor-targeted therapeutic strategies. It will provide reference for research macrophage-centered therapy strategies application clinical practice.

Language: Английский

Citations

0
Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment DOI Creative Commons
Yang Zhang,

Shuhua Gong,

Xiaofei Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Breast cancer is one of the most prevalent cancers in women globally. Its treatment and prognosis are significantly influenced by tumor microenvironment heterogeneity. Precision therapy enhances efficacy, reduces unwanted side effects, maximizes patients’ survival duration while improving their quality life. Spatial transcriptomics significant importance for precise breast cancer, playing a critical role revealing internal structural differences tumors composition microenvironment. It offers novel perspective studying spatial structure cell interactions within tumors, facilitating more effective personalized treatments cancer. This article will summarize latest findings diagnosis from transcriptomics, focusing on revelation microenvironment, identification new therapeutic targets, enhancement disease diagnostic accuracy, comprehension progression metastasis, assessment drug responses, creation high-resolution maps cells, representation heterogeneity, support clinical decision-making, particularly elucidating immunotherapy correlation with outcomes.

Language: Английский

Citations

1