Water Research, Год журнала: 2023, Номер 249, С. 121004 - 121004
Опубликована: Дек. 9, 2023
Язык: Английский
Water Research, Год журнала: 2023, Номер 249, С. 121004 - 121004
Опубликована: Дек. 9, 2023
Язык: Английский
Environmental Chemistry Letters, Год журнала: 2023, Номер 22(1), С. 209 - 226
Опубликована: Окт. 24, 2023
Язык: Английский
Процитировано
25Environmental Chemistry Letters, Год журнала: 2024, Номер 22(3), С. 1185 - 1220
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
12Water Research, Год журнала: 2024, Номер 260, С. 121895 - 121895
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
12Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 1, 2024
Nanoplastics (NPs) are emerging pollutants that pose risks to living organisms. Recent findings have unveiled the reproductive harm caused by polystyrene nanoparticles (PS-NPs) in female animals, yet intricate mechanism remains incompletely understood. Under this research, we investigated whether sustained exposure PS-NPs at certain concentrations vivo can enter oocytes through zona pellucida or other routes affect reproduction. We show disrupted ovarian functions and decreased oocyte quality, which may be a contributing factor lower fertility mice. RNA sequencing of mouse ovaries illustrated PI3K-AKT signaling pathway emerged as predominant environmental information processing responding PS-NPs. Western blotting results cells vitro showed deactivated down-regulating expression PI3K reducing AKT phosphorylation protein level, was accompanied activation autophagy apoptosis disruption steroidogenesis granulosa cells. Since penetrate but not oocytes, examined indirectly quality using cell–oocyte coculture system. Preincubation with causes cell dysfunction, resulting decrease cocultured reversed addition 17β-estradiol. This study provides on how impact function include transcriptome analysis tissue. The demonstrates impair altering functioning Therefore, it is necessary focus research effects reproduction related methods mitigate their toxicity. reduced inhibited ovary viability inducing autophagy. suppressed causing dysfunction.
Язык: Английский
Процитировано
12Environmental and Experimental Botany, Год журнала: 2024, Номер 219, С. 105654 - 105654
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
9Environmental Chemistry Letters, Год журнала: 2024, Номер 22(5), С. 2159 - 2165
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
9Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137466 - 137466
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117906 - 117906
Опубликована: Фев. 1, 2025
Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant increase than controls (36.94 13.22 mg/kg). 5 11 types detected, among which PE (CPP, 28.22 %; Control, 31.62 %) PVC 62.67 58.14 being dominant ones. Correlation analysis between sex hormone revealed negatively correlated with progesterone positively dehydroepiandrosterone (DHEAS). order to investigate toxic effects onset, young female mice at 21 days orally administered various concentrations for two weeks. Female exposed (PE, 3 mg/day; PVC, 6 mg/day) had advanced vaginal opening, none changes body weight. Immunohistochemical staining demonstrated exposure during could activate microglia, astrocytes promote GnRH expression hypothalamus, leading earlier onset. These data suggested can absorbed accumulated brain gonad after gavage, accelerate initiation. This study provided valuable evidence threatened normal progression
Язык: Английский
Процитировано
1Environmental Chemistry Letters, Год журнала: 2023, Номер 21(3), С. 1745 - 1759
Опубликована: Фев. 16, 2023
Язык: Английский
Процитировано
22Reviews of Environmental Contamination and Toxicology, Год журнала: 2023, Номер 261(1)
Опубликована: Март 6, 2023
Язык: Английский
Процитировано
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