Water Research, Journal Year: 2023, Volume and Issue: 249, P. 121004 - 121004
Published: Dec. 9, 2023
Language: Английский
Water Research, Journal Year: 2023, Volume and Issue: 249, P. 121004 - 121004
Published: Dec. 9, 2023
Language: Английский
Environmental Chemistry Letters, Journal Year: 2023, Volume and Issue: 22(1), P. 209 - 226
Published: Oct. 24, 2023
Language: Английский
Citations
25Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(3), P. 1185 - 1220
Published: Feb. 27, 2024
Language: Английский
Citations
12Water Research, Journal Year: 2024, Volume and Issue: 260, P. 121895 - 121895
Published: June 5, 2024
Language: Английский
Citations
12Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 1, 2024
Nanoplastics (NPs) are emerging pollutants that pose risks to living organisms. Recent findings have unveiled the reproductive harm caused by polystyrene nanoparticles (PS-NPs) in female animals, yet intricate mechanism remains incompletely understood. Under this research, we investigated whether sustained exposure PS-NPs at certain concentrations vivo can enter oocytes through zona pellucida or other routes affect reproduction. We show disrupted ovarian functions and decreased oocyte quality, which may be a contributing factor lower fertility mice. RNA sequencing of mouse ovaries illustrated PI3K-AKT signaling pathway emerged as predominant environmental information processing responding PS-NPs. Western blotting results cells vitro showed deactivated down-regulating expression PI3K reducing AKT phosphorylation protein level, was accompanied activation autophagy apoptosis disruption steroidogenesis granulosa cells. Since penetrate but not oocytes, examined indirectly quality using cell–oocyte coculture system. Preincubation with causes cell dysfunction, resulting decrease cocultured reversed addition 17β-estradiol. This study provides on how impact function include transcriptome analysis tissue. The demonstrates impair altering functioning Therefore, it is necessary focus research effects reproduction related methods mitigate their toxicity. reduced inhibited ovary viability inducing autophagy. suppressed causing dysfunction.
Language: Английский
Citations
12Environmental and Experimental Botany, Journal Year: 2024, Volume and Issue: 219, P. 105654 - 105654
Published: Jan. 13, 2024
Language: Английский
Citations
9Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(5), P. 2159 - 2165
Published: May 30, 2024
Language: Английский
Citations
9Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137466 - 137466
Published: Feb. 1, 2025
Language: Английский
Citations
1Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117906 - 117906
Published: Feb. 1, 2025
Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant increase than controls (36.94 13.22 mg/kg). 5 11 types detected, among which PE (CPP, 28.22 %; Control, 31.62 %) PVC 62.67 58.14 being dominant ones. Correlation analysis between sex hormone revealed negatively correlated with progesterone positively dehydroepiandrosterone (DHEAS). order to investigate toxic effects onset, young female mice at 21 days orally administered various concentrations for two weeks. Female exposed (PE, 3 mg/day; PVC, 6 mg/day) had advanced vaginal opening, none changes body weight. Immunohistochemical staining demonstrated exposure during could activate microglia, astrocytes promote GnRH expression hypothalamus, leading earlier onset. These data suggested can absorbed accumulated brain gonad after gavage, accelerate initiation. This study provided valuable evidence threatened normal progression
Language: Английский
Citations
1Environmental Chemistry Letters, Journal Year: 2023, Volume and Issue: 21(3), P. 1745 - 1759
Published: Feb. 16, 2023
Language: Английский
Citations
22Reviews of Environmental Contamination and Toxicology, Journal Year: 2023, Volume and Issue: 261(1)
Published: March 6, 2023
Language: Английский
Citations
18