npj Microgravity, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 19, 2024
Язык: Английский
ACS Sensors, Год журнала: 2024, Номер 9(7), С. 3466 - 3488
Опубликована: Июль 11, 2024
Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology also facing notable challenges, such as lack vascularization, development multiorgan-on-a-chip systems, replication body single chip. The progress has played crucial role in steering OOC toward mimicking microenvironment, including microenvironment replication, multiorgan microphysiological systems. Additionally, advancements detection, analysis, organoid imaging technologies have enhanced efficiency Organs-on-Chips (OOCs). In particular, integration artificial intelligence revolutionized imaging, significantly enhancing high-throughput drug screening. Consequently, review covers research Human-on-a-chip, sensors OOCs, latest applications biomedical field.
Язык: Английский
Процитировано
15
Bioactive Materials, Год журнала: 2025, Номер 47, С. 378 - 402
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Cell organoid (Print), Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101323 - 101323
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11000 - 11000
Опубликована: Окт. 12, 2024
Bioassembly encompasses various techniques such as bioprinting, microfluidics, organoids, and self-assembly, enabling advances in tissue engineering regenerative medicine. Advancements bioassembly technologies have enabled the precise arrangement integration of cell types to more closely mimic complexity functionality neurovascular unit (NVU) that other biodiverse multicellular structures. In this context, bioprinting offers ability deposit cells a spatially controlled manner, facilitating construction interconnected networks. Scaffold-based assembly strategies provide structural support guidance cues for growth, formation complex bio-constructs. Self-assembly approaches utilize inherent properties drive spontaneous organization interaction neuronal vascular components. However, recreating intricate microarchitecture functional characteristics tissue/organ poses additional challenges. materials hold great promise addressing these The further refinement technologies, improved resolution incorporation multiple types, can enhance accuracy biological constructs; however, developing bioinks growth cells, viability, while maintaining compatibility with process remains an unmet need field, advancements design bioactive biodegradable scaffolds will aid controlling adhesion, differentiation, vascularization within engineered tissue. Additionally, integrating advanced imaging analytical real-time monitoring characterization bioassembly, aiding quality control optimization. While challenges remain, ongoing research technological propel field forward, paving way transformative developments engineering. This work provides overview advancements, challenges, future perspectives fabricating constructs add-on focus on technologies.
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)
Опубликована: Авг. 5, 2024
Abstract Targeted cancer therapy (TCT) is gaining increased interest because it reduces the risks of adverse side effects by specifically treating tumor cells. TCT testing has traditionally been performed using two‐dimensional (2D) cell culture and animal studies. Organ‐on‐a‐chip (OoC) platforms have developed to recapitulate in vitro, as cancer‐on‐a‐chip (CoC), used for chemotherapeutics development testing. This review explores use CoCs both develop test TCTs, with a focus on three main aspects, identify target biomarkers development, free, un‐encapsulated encapsulated TCTs. Despite current challenges such system scaling, externally triggered TCToC shows promising future serve supportive, pre‐clinical platform expedite bench‐to‐bedside translation.
Язык: Английский
Процитировано
1
Immuno, Год журнала: 2024, Номер 4(4), С. 312 - 324
Опубликована: Сен. 27, 2024
Recent advances in organoid technology have revolutionized cancer biology and therapeutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvironment, providing unprecedented insights into tumor-immune interactions responses. In this literature-based study, we discuss various culture methods for diverse applications of organoids immunotherapy, including drug screening, treatment strategies, mechanistic studies. Additionally, address technological challenges associated with these propose potential future solutions to accelerate development novel immunotherapeutic approaches. This review highlights transformative models advancing preclinical modeling, evaluation, paving way more effective treatments.
Язык: Английский
Процитировано
1
Опубликована: Авг. 12, 2024
Recent advances in organoid technology have revolutionized cancer biology and thera-peutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvi-ronment, providing unprecedented insights into tumor-immune interactions therapeutic re-sponses. In this literature-based study, we discuss various culture methods for diverse appli-cations of organoids immunotherapy, including drug screening, treatment strategies, mechanistic studies. Additionally, address technological challenges asso-ciated with these propose potential future solutions to accelerate development novel immunotherapeutic approaches. This review highlights transformative or-ganoid models advancing preclinical modeling, evalua-tion, paving way more effective treatments.
Язык: Английский
Процитировано
0
npj Microgravity, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 19, 2024
Язык: Английский
Процитировано
0