Circulating Extracellular Vesicles as Promising Biomarkers for Precession Diagnostics: A Perspective on Lung Cancer DOI

Sunil Vasu,

Vinith Johnson,

M Archana

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 11(1), С. 95 - 134

Опубликована: Дек. 5, 2024

Extracellular vesicles (EVs) have emerged as promising biomarkers in liquid biopsy, owing to their ubiquitous presence bodily fluids and ability carry disease-related cargo. Recognizing significance disease diagnosis treatment, substantial efforts been dedicated developing efficient methods for EV isolation, detection, analysis. EVs, heterogeneous membrane-encapsulated secreted by all cells, contain bioactive substances capable of modulating recipient cell biology upon internalization, including proteins, lipids, DNA, various RNAs. Their prevalence across has positioned them pivotal mediators physiological pathological processes, notably cancer, where they hold potential straightforward tumor biomarkers. This review offers a comprehensive examination advanced nanotechnology-based techniques detecting lung cancer through It begins providing brief overview exosomes role progression. Furthermore, this explores the evolving landscape isolation cargo analysis, highlighting importance characterizing specific biomolecular signatures within EVs improved diagnostic accuracy patients. Innovative strategies enhancing sensitivity specificity integration microfluidic platforms multiplexed biosensing technologies are summarized. The discussion then extends key challenges associated with EV-based biopsies, such standardization detection protocols establishment robust analytical clinical translation. highlights transformative impact biopsy diagnosis, heralding new era personalized medicine patient care.

Язык: Английский

Circular RNA translation: novel protein isoforms and clinical significance DOI
Shuo‐Yang Wen, Javeria Qadir, Burton B. Yang

и другие.

Trends in Molecular Medicine, Год журнала: 2022, Номер 28(5), С. 405 - 420

Опубликована: Апрель 2, 2022

Язык: Английский

Процитировано

95
Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators DOI
Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi

и другие.

Cellular Signalling, Год журнала: 2020, Номер 78, С. 109871 - 109871

Опубликована: Дек. 4, 2020

Язык: Английский

Процитировано

122
Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect DOI Creative Commons
Hamed Mirzaei, Michael R. Hamblin

Molecular Therapy — Oncolytics, Год журнала: 2020, Номер 19, С. 218 - 239

Опубликована: Окт. 10, 2020

The "Warburg effect" describes the reprogramming of glucose metabolism away from oxidative phosphorylation toward aerobic glycolysis, and it is one hallmarks cancer cells. Several factors can be involved in this process, but review, roles non-coding RNAs (ncRNAs) are highlighted several types human cancer. ncRNAs, including microRNAs, long RNAs, circular all affect metabolic enzymes transcription to promote glycolysis modulate enhance progression tumors. In particular, 5'-AMP-activated protein kinase (AMPK) phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) pathways associated with alterations ncRNAs. A better understanding ncRNAs Warburg effect could ultimately lead new therapeutic approaches for suppressing

Язык: Английский

Процитировано

103
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers DOI

Fatma Saaoud,

Charles Drummer I.V.,

Ying Shao

и другие.

Pharmacology & Therapeutics, Год журнала: 2020, Номер 220, С. 107715 - 107715

Опубликована: Окт. 24, 2020

Язык: Английский

Процитировано

90
Pathogenesis and therapeutic strategy in platinum resistance lung cancer DOI
Panpan Lv,

Shuli Man,

Lu Xie

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2021, Номер 1876(1), С. 188577 - 188577

Опубликована: Июнь 4, 2021

Язык: Английский

Процитировано

58
The regulatory relationship between transcription factor STAT3 and noncoding RNA DOI Creative Commons
Siyi Liu, Wentao Li,

Lin Liang

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 3, 2024

Abstract Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated various tumor tissues plays important roles formation, metastasis, drug resistance. STAT3 considered potential subtarget for therapy. Noncoding RNA (ncRNA) special type transcript. Transforming from “junk” transcripts into molecules involved cell apoptosis, growth, functional regulation, ncRNA has been proven to be closely related epithelial–mesenchymal transition resistance processes cells over the past few decades. Research on relationship between factor ncRNAs attracted increased attention. To date, existing reviews have mainly focused regulation by STAT3; there no review ncRNAs. However, understanding its mechanism comprehensively understand mutual regulatory Therefore, this review, we summarize long noncoding RNA, microRNA, circular possible mechanisms. In addition, provide an update research progress This will new perspective ncRNAs, well targeting or treat diseases such tumors.

Язык: Английский

Процитировано

18
Natural products reverse cisplatin resistance in the hypoxic tumor microenvironment DOI

Chuansheng Yang,

Xinpei Deng,

Yunyun Tang

и другие.

Cancer Letters, Год журнала: 2024, Номер 598, С. 217116 - 217116

Опубликована: Июль 14, 2024

Язык: Английский

Процитировано

11
Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives DOI Creative Commons
Huanhuan Chen, Tie‐Ning Zhang, Qi‐Jun Wu

и другие.

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Июль 6, 2021

Globally, lung cancer is the most commonly diagnosed and carries with it greatest mortality rate, 5-year survival rates varying from 4–17% depending on stage geographical differences. For decades, researchers have studied disease mechanisms, occurrence development, however, mechanisms underlying progression are not yet fully elucidated, thus an increased understanding of pathogenesis key to developing new strategies towards specific diagnoses targeted treatments. Circular RNAs (circRNAs) a class non-coding RNA widely expressed in eukaryotic cells, participate various biological processes implicated human disease. Recent studies indicated that circRNAs both positively negatively regulate cell proliferation, migration, invasion apoptosis. Additionally, could be promising biomarkers targets for therapies. This review systematically highlights recent advances circRNA regulatory roles cancer, sheds light their use as potential treatment this

Язык: Английский

Процитировано

42
Circular RNAs as biomarkers for lung cancer DOI Creative Commons
Albert Sufianov, Sema Begliarzade, Aferin Beilerli

и другие.

Non-coding RNA Research, Год журнала: 2022, Номер 8(1), С. 83 - 88

Опубликована: Ноя. 7, 2022

Lung cancer is the leading cause of death and morbidity from malignant neoplasms worldwide, its poor prognosis places a heavy burden on patients. A large percentage lung cases are associated with smoking. significant number non-smokers also develop disease, suggesting an epigenetic genetic mechanism for development cancer. The current situation diagnosis treatment remains grim, effective therapeutic targets molecular markers urgently needed. Circular RNAs (circRNAs) covalently closed non-coding that have received much attention due to their biological properties such as conservatism, stability, tissue specificity. Many studies shown circRNAs involved in regulation through various mechanisms, microRNA adsorption, play important role early diagnosis, treatment, In recent years, it has become increasingly clear proliferation, migration, invasion cells. Differentially expressed can be used non-invasive diagnostic prognostic This article summarizes advances

Язык: Английский

Процитировано

31
Circular RNAs as Key Regulators in Cancer Hallmarks: New Progress and Therapeutic Opportunities DOI Creative Commons
Bashdar Mahmud Hussen, Snur Rasool Abdullah, Rohana Jaafar

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104612 - 104612

Опубликована: Янв. 1, 2025

Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, tissue-specific expression. These non-coding function through mechanisms such miRNA sponging, interactions with RNA-binding proteins (RBPs), modulating transcription splicing. Advances RNA sequencing bioinformatics tools enabled the identification functional annotation of across different types. Clinically, demonstrate specificity sensitivity samples, offering potential diagnostic prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, delivery systems are under investigation. However, precise remain unclear, more clinical evidence is needed regarding roles hallmarks. Understanding will pave way for novel approaches, potentially improving patient outcomes.

Язык: Английский

Процитировано

1