Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 23, 2025
Lung
cancer
is
one
of
the
most
prevalent
malignant
tumors
globally,
posing
significant
challenges
to
treatment
outcomes.
Circular
RNAs
(circRNAs),
a
novel
class
non-coding
RNAs,
have
emerged
as
crucial
regulators
in
biology,
influencing
drug
resistance,
progression,
and
prognosis.
Due
their
closed-loop
structure,
circRNAs
demonstrate
high
stability
resistance
degradation,
making
them
promising
diagnostic
therapeutic
targets.
Here
we
summarize
mechanisms
by
which
mediate
lung
cancer,
focusing
on
roles
chemotherapy,
targeted
therapies,
immunotherapy.
We
highlight
how
interact
with
microRNAs
(miRNAs)
proteins
regulate
signaling
pathways
alter
sensitivity.
Additionally,
circRNA
expression
patterns
hold
potential
biomarkers
for
predicting
response.
By
synthesizing
latest
research,
offer
new
insights
into
functions
suggest
future
directions
overcoming
cancer.
Abstract
Signal
transducer
and
activator
of
transcription
3
(STAT3),
as
a
key
node
in
numerous
carcinogenic
signaling
pathways,
is
activated
various
tumor
tissues
plays
important
roles
formation,
metastasis,
drug
resistance.
STAT3
considered
potential
subtarget
for
therapy.
Noncoding
RNA
(ncRNA)
special
type
transcript.
Transforming
from
“junk”
transcripts
into
molecules
involved
cell
apoptosis,
growth,
functional
regulation,
ncRNA
has
been
proven
to
be
closely
related
epithelial–mesenchymal
transition
resistance
processes
cells
over
the
past
few
decades.
Research
on
relationship
between
factor
ncRNAs
attracted
increased
attention.
To
date,
existing
reviews
have
mainly
focused
regulation
by
STAT3;
there
no
review
ncRNAs.
However,
understanding
its
mechanism
comprehensively
understand
mutual
regulatory
Therefore,
this
review,
we
summarize
long
noncoding
RNA,
microRNA,
circular
possible
mechanisms.
In
addition,
provide
an
update
research
progress
This
will
new
perspective
ncRNAs,
well
targeting
or
treat
diseases
such
tumors.
Molecular Therapy — Oncolytics,
Journal Year:
2020,
Volume and Issue:
19, P. 218 - 239
Published: Oct. 10, 2020
The
"Warburg
effect"
describes
the
reprogramming
of
glucose
metabolism
away
from
oxidative
phosphorylation
toward
aerobic
glycolysis,
and
it
is
one
hallmarks
cancer
cells.
Several
factors
can
be
involved
in
this
process,
but
review,
roles
non-coding
RNAs
(ncRNAs)
are
highlighted
several
types
human
cancer.
ncRNAs,
including
microRNAs,
long
RNAs,
circular
all
affect
metabolic
enzymes
transcription
to
promote
glycolysis
modulate
enhance
progression
tumors.
In
particular,
5'-AMP-activated
protein
kinase
(AMPK)
phosphatidylinositol
3-kinase
(PI3K)/AKT/mammalian
target
rapamycin
(mTOR)
pathways
associated
with
alterations
ncRNAs.
A
better
understanding
ncRNAs
Warburg
effect
could
ultimately
lead
new
therapeutic
approaches
for
suppressing
Critical Reviews in Oncology/Hematology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104612 - 104612
Published: Jan. 1, 2025
Circular
RNAs
(circRNAs)
have
emerged
as
critical
regulators
in
cancer
biology,
contributing
to
various
hallmarks,
including
cell
proliferation,
apoptosis,
metastasis,
and
drug
resistance.
Defined
by
their
covalently
closed
loop
structure,
circRNAs
possess
unique
characteristics
like
high
stability,
abundance,
tissue-specific
expression.
These
non-coding
function
through
mechanisms
such
miRNA
sponging,
interactions
with
RNA-binding
proteins
(RBPs),
modulating
transcription
splicing.
Advances
RNA
sequencing
bioinformatics
tools
enabled
the
identification
functional
annotation
of
across
different
types.
Clinically,
demonstrate
specificity
sensitivity
samples,
offering
potential
diagnostic
prognostic
biomarkers.
Additionally,
therapeutic
strategies
involving
circRNA
mimics,
inhibitors,
delivery
systems
are
under
investigation.
However,
precise
remain
unclear,
more
clinical
evidence
is
needed
regarding
roles
hallmarks.
Understanding
will
pave
way
for
novel
approaches,
potentially
improving
patient
outcomes.
Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
11
Published: July 6, 2021
Globally,
lung
cancer
is
the
most
commonly
diagnosed
and
carries
with
it
greatest
mortality
rate,
5-year
survival
rates
varying
from
4–17%
depending
on
stage
geographical
differences.
For
decades,
researchers
have
studied
disease
mechanisms,
occurrence
development,
however,
mechanisms
underlying
progression
are
not
yet
fully
elucidated,
thus
an
increased
understanding
of
pathogenesis
key
to
developing
new
strategies
towards
specific
diagnoses
targeted
treatments.
Circular
RNAs
(circRNAs)
a
class
non-coding
RNA
widely
expressed
in
eukaryotic
cells,
participate
various
biological
processes
implicated
human
disease.
Recent
studies
indicated
that
circRNAs
both
positively
negatively
regulate
cell
proliferation,
migration,
invasion
apoptosis.
Additionally,
could
be
promising
biomarkers
targets
for
therapies.
This
review
systematically
highlights
recent
advances
circRNA
regulatory
roles
cancer,
sheds
light
their
use
as
potential
treatment
this
Non-coding RNA Research,
Journal Year:
2022,
Volume and Issue:
8(1), P. 83 - 88
Published: Nov. 7, 2022
Lung
cancer
is
the
leading
cause
of
death
and
morbidity
from
malignant
neoplasms
worldwide,
its
poor
prognosis
places
a
heavy
burden
on
patients.
A
large
percentage
lung
cases
are
associated
with
smoking.
significant
number
non-smokers
also
develop
disease,
suggesting
an
epigenetic
genetic
mechanism
for
development
cancer.
The
current
situation
diagnosis
treatment
remains
grim,
effective
therapeutic
targets
molecular
markers
urgently
needed.
Circular
RNAs
(circRNAs)
covalently
closed
non-coding
that
have
received
much
attention
due
to
their
biological
properties
such
as
conservatism,
stability,
tissue
specificity.
Many
studies
shown
circRNAs
involved
in
regulation
through
various
mechanisms,
microRNA
adsorption,
play
important
role
early
diagnosis,
treatment,
In
recent
years,
it
has
become
increasingly
clear
proliferation,
migration,
invasion
cells.
Differentially
expressed
can
be
used
non-invasive
diagnostic
prognostic
This
article
summarizes
advances
