Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1099 - 1099
Опубликована: Май 1, 2025
With
the
advent
of
new
therapeutic
approaches,
there
is
hope
that
anticancer
treatment
will
eventually
be
possible
without
use
chemotherapy.
Efficient
immunotherapeutic
options
have
recently
emerged
in
many
cancers,
offering
a
less
aggressive
approach,
with
overall
better
tolerance,
making
them
also
suitable
for
frail
patients.
Response
to
immunotherapy
relies
on
availability,
functionality,
and
efficacy
host's
immune
effector
mechanisms.
One
key
factors
determining
tumor
microenvironment,
which
encompasses
various
effectors,
including
macrophages,
play
crucial
role
regulating
responses
through
phagocytosis
antigen
presentation.
Macrophages
are
prototypically
divided,
according
their
polarization,
into
either
pro-inflammatory
M1
type
or
anti-inflammatory
M2
type.
In
M2-polarized
known
as
tumor-associated
macrophages
(TAMs),
predominant
phenotype
associated
progression.
The
M1/M2
paradigm
contributes
understanding
Due
variable
mechanisms
TAMs
can
vary
across
different
cancers.
Variations
TAM
polarization
may
account
patients
similar
diseases.
This
paper
investigates
connection
between
TAMs,
disease
progression,
most
frequent
solid
hematologic
cancer,
diffuse
large
B-cell
lymphoma.
Cancers,
Год журнала:
2022,
Номер
14(4), С. 976 - 976
Опубликована: Фев. 15, 2022
Emerging
evidence
suggests
that
a
small
subpopulation
of
cancer
stem
cells
(CSCs)
is
responsible
for
initiation,
progression,
and
metastasis
cascade
in
tumors.
CSCs
share
characteristics
with
normal
cells,
i.e.,
self-renewal
differentiation
potential,
suggesting
they
can
drive
progression.
Consequently,
targeting
to
prevent
tumor
growth
or
regrowth
might
offer
chance
lead
the
fight
against
cancer.
create
their
niche,
specific
area
within
tissue
unique
microenvironment
sustains
vital
functions.
Interactions
between
niches
play
critical
role
regulating
CSCs'
tumorigenesis.
Differences
observed
frequency
CSCs,
due
phenotypic
plasticity
many
remain
challenge
therapeutics,
since
modulate
transcriptional
activities
into
more
stem-like
state
protect
themselves
from
destruction.
This
represents
an
essential
step
future
therapeutic
approaches.
Regarding
self-renewal,
are
modulated
by
same
molecular
pathways
found
such
as
Wnt/β-catenin
signaling,
Notch
Hedgehog
signaling.
Another
key
characteristic
resistance
standard
chemotherapy
radiotherapy
treatments,
capacity
rest
quiescent
state.
review
will
analyze
primary
mechanisms
involved
CSC
tumorigenesis,
particular
attention
roles
progression
benign
malignant
diseases;
examine
perspectives
on
identification
new
markers
better
control
well
dissecting
process.
Cellular and Molecular Immunology,
Год журнала:
2023,
Номер
20(7), С. 714 - 738
Опубликована: Май 19, 2023
Abstract
Breast
cancer
is
the
most
prevalent
worldwide,
and
metastasis
leading
cause
of
death
in
patients.
Human
monocyte
chemoattractant
protein-1
(MCP-1/CCL2)
was
isolated
from
culture
supernatants
not
only
mitogen-activated
peripheral
blood
mononuclear
leukocytes
but
also
malignant
glioma
cells
based
on
its
vitro
chemotactic
activity
toward
human
monocytes.
MCP-1
subsequently
found
to
be
identical
a
previously
described
tumor
cell-derived
factor
thought
responsible
for
accumulation
tumor-associated
macrophages
(TAMs),
it
became
candidate
target
clinical
intervention;
however,
role
TAMs
development
still
controversial
at
time
discovery
MCP-1.
The
vivo
progression
first
evaluated
by
examining
tissues,
including
breast
cancers.
Positive
correlations
between
level
production
tumors
degree
TAM
infiltration
were
established.
contribution
growth
primary
lung,
bone,
brain
examined
mouse
models.
results
these
studies
strongly
suggested
that
promoter
lung
bone.
Potential
mechanisms
microenvironment
have
been
reported.
In
present
manuscript,
we
review
which
attempt
draw
consensus
discuss
potential
use
as
biomarker
diagnosis.
Cellular and Molecular Immunology,
Год журнала:
2023,
Номер
20(7), С. 739 - 776
Опубликована: Май 17, 2023
Abstract
Over
the
past
thirty
years,
importance
of
chemokines
and
their
seven-transmembrane
G
protein-coupled
receptors
(GPCRs)
has
been
increasingly
recognized.
Chemokine
interactions
with
trigger
signaling
pathway
activity
to
form
a
network
fundamental
diverse
immune
processes,
including
host
homeostasis
responses
disease.
Genetic
nongenetic
regulation
both
expression
structure
conveys
chemokine
functional
heterogeneity.
Imbalances
defects
in
system
contribute
pathogenesis
variety
diseases,
cancer,
inflammatory
metabolic
neurological
disorders,
which
render
focus
studies
aiming
discover
therapies
important
biomarkers.
The
integrated
view
biology
underpinning
divergence
plasticity
provided
insights
into
dysfunction
disease
states,
including,
among
others,
coronavirus
2019
(COVID-19).
In
this
review,
by
reporting
latest
advances
results
from
analyses
plethora
sequencing-based
datasets,
we
outline
recent
understanding
genetic
variations
heterogeneity
provide
an
updated
contribution
pathophysiological
network,
focusing
on
chemokine-mediated
inflammation
cancer.
Clarification
molecular
basis
dynamic
chemokine-receptor
will
help
advance
achieve
precision
medicine
application
clinic.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
CCL2,
a
pivotal
cytokine
within
the
chemokine
family,
functions
by
binding
to
its
receptor
CCR2.
The
CCL2/CCR2
signaling
pathway
plays
crucial
role
in
development
of
fibrosis
across
multiple
organ
systems
modulating
recruitment
and
activation
immune
cells,
which
turn
influences
progression
fibrotic
diseases
liver,
intestines,
pancreas,
heart,
lungs,
kidneys,
other
organs.
This
paper
introduces
biological
CCL2
CCR2,
highlighting
their
similarities
differences
concerning
disorders
various
systems,
reviews
recent
progress
diagnosis
treatment
clinical
linked
pathway.
Additionally,
further
in-depth
research
is
needed
explore
significance
axis
conditions
affecting
different
Seminars in Cancer Biology,
Год журнала:
2022,
Номер
86, С. 436 - 449
Опубликована: Июнь 11, 2022
Colorectal
cancer
(CRC)
is
considered
the
second
cause
of
death
worldwide.
The
early
diagnosis
plays
a
key
role
in
patient
prognosis
and
subsequently
overall
survival.
Similar
to
several
types
cancer,
colorectal
also
characterised
by
drug
resistance
heterogeneity
that
contribute
its
complexity
-especially
at
advanced
stages.
However,
despite
extensive
research
related
identification
biomarkers
associated
diagnosis,
accurate
management
CRC
patients,
little
progress
has
been
made
thus
far.
Therefore,
mortality
rates,
especially
stages,
remain
high.
A
large
family
chemoattractant
cytokines
called
chemokines
are
known
for
their
significant
inflammation
immunity.
Chemokines
released
different
tumorous
cells
play
increasing
tumour's
microenvironment.
current
review
investigates
chemokine
receptors
potential
as
clinical
molecular
signatures
could
be
effectively
used
personalised
therapeutic
approach.
We
discussed
how
regulate
microenvironment
lead
CRC.
An
important
aspect
which
extensively
discussed.
This
provides
an
overview
advances
search
