Global epidemiology of breast cancer based on risk factors: a systematic review

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Окт. 10, 2023

Numerous reviews of the epidemiology and risk factors for breast cancer have been published previously which heighted different directions cancer.The present review examined likelihood that incidence, prevalence, particular might vary by geographic region possibly food cultural practices as well.A systematic (2017-2022) was conducted following Preferred Reporting Items Systematic Reviews Meta-analyses (PRISMA) guidelines, reporting on epidemiological factor reports from world regions. Medical Subject Heading (MeSH) terms: "Breast neoplasm" "AND" country terms such "Pakistan/epidemiology", "India/epidemiology", "North America/epidemiology", "South Africa/epidemiology" were used to retrieve 2068 articles PubMed. After applying inclusion exclusion terms, 49 papers selected review.Results summarized based factors, regions study type. Risk classified into five categories: demographic, genetic lifestyle varied among countries. This article covers a variety topics, including regions, main findings, associated lifestyle. Several studies revealed choices diet exercise could affect person's chance developing cancer. Breast has also linked variables, DNA repair gene polymorphisms mutations in (BRCA). It found most variability links population Asia while cause due modifications American British people, indicating genetic, and, countries.There are many cancer, their importance depending region. However, further investigation is required better comprehend causes these areas well create efficient prevention treatment plans cater local population.

Язык: Английский

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Health effects of the time-restricted eating in adults with obesity: A systematic review and meta-analysis

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Фев. 16, 2023

The number of people suffering from overweight or obesity has been steadily increasing in recent years. As a new form diet, the efficacy time-restricted eating (TRE) remains debatable.This meta-analysis quantified effect TRE on weight change and other physical parameters obese adults.We did systematic review randomized controlled trials (RCTs) comparing interventions loss metabolic by searching PubMed, Embase, Cochrane Central Register Controlled Trials to identify eligible published database inception up until 23 August 2022. risk bias was assessed using Revised risk-of-bias tool (ROB-2.0). Meta-analysis performed Review Manager 5.4.1 software.Nine RCTs with 665 individuals (345 group while 320 control group) were included. Results indicated that had greater decrease body (-1.28 kg; 95% CI [-2.05, -0.52], p = 0.001), fat mass (-0.72 [-1.40, -0.03], 0.04), index (-0.34 kg/m2; [-0.64, -0.04], 0.03) diastolic blood pressure (-2.26 mmHg [-4.02, -0.50], 0.01). However, demonstrated there no significant difference between lean mass, systolic pressure, waist circumference, fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), total cholesterol, high-density lipoprotein, low-density triglycerides. Besides, duration study daily window also an impact change.TRE associated reductions can be dietary intervention option for adults obesity. But high-quality longer follow-ups are needed draw definitive conclusions.

Язык: Английский

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Research advances in the therapy of metabolic syndrome

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 30, 2024

Metabolic syndrome refers to the pathological state of metabolic disorder protein, fat, carbohydrate, and other substances in human body. It is a composed group complex disorders, whose pathogenesis includes multiple genetic acquired entities falling under category insulin resistance chronic low-grade inflammationand. risk factor for increased prevalence mortality from diabetes cardiovascular disease. Cardiovascular diseases are predominant cause morbidity globally, thus it imperative investigate impact on alleviating this substantial disease burden. Despite increasing number scientists dedicating themselves researching recent decades, numerous aspects condition remain incompletely understood, leaving many questions unanswered. In review, we present an epidemiological analysis MetS, explore both traditional novel pathogenesis, examine pathophysiological repercussions syndrome, summarize research advances, elucidate mechanisms underlying corresponding treatment approaches.

Язык: Английский

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Targeting Adiponectin in Breast Cancer

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2958 - 2958

Опубликована: Ноя. 17, 2022

Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, relationship between obesity has been well established extensively investigated. There is strong evidence overweight increase risk of postmenopausal cancer, adipokines central players in this relationship. Produced secreted predominantly by white adipose tissue, adiponectin a bioactive molecule exhibits numerous protective effects considered guardian angel adipokine. obesity–cancer relationship, more shows may prevent protect individuals from developing cancer. Recently, several updates have published on implication regulating tumor development, progression, metastases. review, we provide an updated overview metabolic signaling linking all its stages. On other hand, critically summarize available promising candidates reactivate these pathways mainly targeting receptors. These molecules synthetic small or plant-based proteins. Interestingly, advances genomics made it possible create peptide sequences specifically replace adiponectin, activate receptor, mimic function. Thus, obvious anti-cancer activity should better exploited, must regarded serious biomarker targeted order confront threatening disease.

Язык: Английский

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Time-restricted eating with calorie restriction on weight loss and cardiometabolic risk: a systematic review and meta-analysis

European Journal of Clinical Nutrition, Год журнала: 2023, Номер 77(11), С. 1014 - 1025

Опубликована: Июль 24, 2023

Abstract The effect of time-restricted eating (TRE) has been summarized in previous studies, but its benefits combination with calorie restriction (CR) still need to be determined. present meta-analysis aimed evaluate the efficacy TRE CR on weight loss and cardiometabolic risk. PubMed, Embase, Cochrane Library, gray literature databases were searched from inception October 18, 2022, for potential randomized controlled trial (RCT) studies based predefined inclusion exclusion criteria. Body other risk factors described as weighted mean difference (WMD) a 95% confidence interval (CI). Eight RCTs involving 579 participants enrolled analysis. pooled results showed that reduced body weight, fat mass, waist circumference significantly (WMD: −1.40, CI: −1.81 −1.00, I 2 : 0%; WMD: −0.73, −1.39 −0.07, −1.87, −3.47 −0.26, 67.25%, respectively). However, compared alone, plus exhibited no significant benefit blood pressure, glucose profile, lipid profile. Subgroup analysis suggested early is more effective −1.42, −1.84 −1.01, 0%) improving mass −1.06, −1.91 −0.22, than delayed or broader when combined CR. Although can effectively decrease circumference, long-term effects, particularly those chronic cardiovascular disease diabetes, remain explored.

Язык: Английский

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Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 3, 2023

Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate and how TRF impacts progression.This study used multiple cell lines, two xenograft mouse models, a chemical-treated model. Stable TIM-knockdown TIM-overexpressing A549 cells were constructed. Cancer behaviors in vitro determined colony formation, EdU proliferation, wound healing, transwell migration, flow cytometer, CCK8 assays. Immunofluorescence, pathology examinations, targeted metabolomics also tumor tissues. mCherry-GFP-LC3 plasmid was detect autophagic flux.We found for the first time that compared normal ad libitum feeding, inhibited progression reprogrammed rhythms metabolites or genes involved glycolysis tumors. After intervention, only timeless (TIM) gene among five cancer-associated clock consistently align Further, demonstrated anti-tumor upon partially mediated rhythmic downregulation TIM subsequent activation autophagy. Combining with inhibition further enhanced effect, comparable treatment efficacy chemotherapy model.Six-hour inhibits reshapes metabolism, which is upregulation

Язык: Английский

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Oncothermia and Integrative Medicine—A Novel Paradigm for Infratentorial Meningioma Management: A Case Report With One-Year Follow-Up

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Infratentorial meningiomas (IM) pose unique challenges in treatment due to their location and proximity critical neurovascular structures such as cranial nerves, arteries, veins, etc. This case report presents the efficacy of an integrative medicine approach managing IM, highlighting multidisciplinary collaboration modern medicine, yoga, naturopathy, homeopathy. A 60-year-old male with deemed unsuitable for surgery, underwent a tailored protocol involving oncothermia, ozone therapy, high-dose vitamin C, hydrogen inhalation, time-restricted feeding, hydrotherapy, biologicals, acupuncture, yoga. Follow-up assessments revealed significant symptom reduction, stable biochemical markers, tumor size reduction observed MRI scans. While individual modalities have demonstrated benefits cancer care, this underscores potential integrating diverse therapies address multifaceted IM. The findings offer valuable insights into evolving landscape brain management, suggesting promise improved patient outcomes enhanced quality life. Further research clinical trials are warranted comprehensively evaluate safety approaches IM treatment.

Язык: Английский

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Habitual sleep duration, healthy eating, and digestive system cancer mortality

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 27, 2025

Abstract Background Lifestyle choices, such as dietary patterns and sleep duration, significantly impact the health of digestive system may influence risk mortality from cancer. Methods This study aimed to examine associations between habits, cancers. The analysis included 406,584 participants UK Biobank cohort (54.1% women; age range: 38–73 years), with duration classified short (≤ 6 h, 24.2%), normal (7–8 68.4%), long (≥ 9 7.4%). Healthy eating habits were defined a daily intake at least 25 g fibre, seven portions fruits vegetables, fewer than four servings meat per week. These factors combined into score ranging 0 (least healthy) 3 (healthiest). Cox proportional hazards regression analyses conducted, median follow-up period 12.6 years, ending on September 30, 2021. Results 3949 died cancer system. Both associated an increased (1.09 (1.01–1.18) 1.14 (1.03–1.27), respectively). Additionally, diet ≥ 1 was linked lower (0.72–0.91 (0.59–0.96)). Adjusting for smoking, type 2 diabetes, body mass index (BMI) status eliminated association mortality. healthy did not vary by duration. Conclusions Aberrant durations increase cancer, potentially through higher BMI, diabetes. However, aberrant do seem reduce protective effects pattern.

Язык: Английский

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The effect of obesity and body composition on cancer risk: a nutritional perspective

Salud Ciencia y Tecnología, Год журнала: 2025, Номер 5, С. 1284 - 1284

Опубликована: Янв. 21, 2025

Introduction: Obesity is an important risk factor for several types of cancer due to mechanisms such as chronic inflammation and metabolic dysfunctions. In Latin America Ecuador, obesity affects a large sector the population, including children, which increases relevance preventive measures that promote adequate body composition healthy eating habits. Objective: To analyze relationship between obesity, cancer, in addition analyzing how nutritional physical activity strategies can influence its prevention. Materials Methods: A narrative review was carried out based on 20 scientific articles extracted from databases Scielo, PubMed Google Scholar, published 2020 2024. Studies were included, excluding those did not address this relationship. directly. Results: Excess weight organs esophagus, liver breast. Diets Mediterranean diet, rich antioxidants, reduce risk, while consumption processed meats alcohol it. Discussion: Structured personalized interventions are effective improving reducing incidence cancer. Conclusion: It crucial lifestyle habits, combining balanced diet with exercise, prevent improve quality life.

Язык: Английский

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Beyond the Scales: A Qualitative Study on the Biopsychosocial Impacts of Time-Restricted Eating in Free-Living Individuals

Obesities, Год журнала: 2025, Номер 5(1), С. 10 - 10

Опубликована: Фев. 18, 2025

Time-restricted eating (TRE) has gained attention as an effective approach for weight management and overall well-being by focusing on limiting the window, rather than reducing calories. This study explores biopsychosocial impacts of TRE in free-living individuals using a qualitative design. Twenty-one adults (aged 27–60 years) from Western Australia who had practised at least three months were purposively recruited, semi-structured interviews conducted. The data analysed thematic analysis to identify key themes. participants reported range benefits, including loss, reduced joint pain, better digestion, improved mental clarity, increased energy, more positive body image. Socially, facilitated simplified daily routines but also introduced challenges, such disruptions social interactions family meal dynamics. Some mixed negative reported, changes sleep exercise patterns. These findings highlight TRE’s potential holistic dietary intervention. Further research, particularly well-controlled, randomised controlled trials longitudinal studies, is needed confirm these insights guide their appropriate application clinical public health settings.

Язык: Английский

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