Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from national health and nutrition examination survey

Nutrition and Diabetes, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 27, 2024

Abstract Objective To investigate the association of timing, frequency, and food quality night eating with all-cause, cancer, diabetes mortality. Methods This study included 41,744 participants from US National Health Nutrition Examination Survey (2002–2018). Night information was collected by 24-h dietary recall exposures were eating. Food assessed latent class analysis. The outcomes mortality, which identified Death Index International Classification Diseases 10th Revision. Adjusted hazard ratios [aHR] 95% confidence intervals [CI] computed Cox regression. Results During a median follow-up 8.7 years, 6066 deaths documented, including 1381 cancer 206 diabetes. Compared no (eating before 22:00), later timing associated higher risk all-cause mortality (each P -trend <0.05) rather than highest being 00:00–1:00 (aHR 1.38, CI 1.02–1.88) 23:00–00:00 2.31, 1.21–4.40), respectively. However, increased risks not observed for 22:00-23:00. Likewise, one time or over frequency < 0.05). That further in high-dietary-energy-density group (all-cause mortality: aHR 1.21 [95% 1.06–1.38]; 1.97 1.13–3.45]), but low-dietary-energy-density group. Finally, correlation analysis found positive associations glycohemoglobin, fasting glucose, OGTT. Conclusions mortality; however, reduction excess when 23:00 foods.

Язык: Английский

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Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes

Biomedical Journal, Год журнала: 2025, Номер unknown, С. 100827 - 100827

Опубликована: Янв. 1, 2025

The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral oscillators for daily coordination of behavior and physiology. SCN entrain to environmental 24-h light-dark (LD) cycle drive rhythms internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, well behavioral feeding-fasting rhythms, which supply signals setting molecular clocks tissues. Steady phase relationships between keep homeostatic processes microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount quality, psychophysiological stress, etc. Indeed, risk health alterations increase when these are chronically changed prompting disruption (CD), occurring after sudden LD changes (so-called jet-lag), or due activity/feeding-rest/fasting rhythm respect cycles (as humans subjected nightwork, restricting food access rest in mice). Typical pathologies observed animal models CD epidemiological studies include syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, disruption, decrease physical cognitive performance, mood, among others. present review discusses different aspects physiological dysregulations having altered potential translation human health.

Язык: Английский

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Oncothermia and Integrative Medicine—A Novel Paradigm for Infratentorial Meningioma Management: A Case Report With One-Year Follow-Up

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Infratentorial meningiomas (IM) pose unique challenges in treatment due to their location and proximity critical neurovascular structures such as cranial nerves, arteries, veins, etc. This case report presents the efficacy of an integrative medicine approach managing IM, highlighting multidisciplinary collaboration modern medicine, yoga, naturopathy, homeopathy. A 60-year-old male with deemed unsuitable for surgery, underwent a tailored protocol involving oncothermia, ozone therapy, high-dose vitamin C, hydrogen inhalation, time-restricted feeding, hydrotherapy, biologicals, acupuncture, yoga. Follow-up assessments revealed significant symptom reduction, stable biochemical markers, tumor size reduction observed MRI scans. While individual modalities have demonstrated benefits cancer care, this underscores potential integrating diverse therapies address multifaceted IM. The findings offer valuable insights into evolving landscape brain management, suggesting promise improved patient outcomes enhanced quality life. Further research clinical trials are warranted comprehensively evaluate safety approaches IM treatment.

Язык: Английский

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Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice

Cancers, Год журнала: 2024, Номер 16(8), С. 1513 - 1513

Опубликована: Апрель 16, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and C as leading cause of chronic in most parts Western world. MASLD (formerly known NAFLD) encompasses both simple steatosis more aggressive metabolic steatohepatitis (MASH), which is accompanied by inflammation, fibrosis, cirrhosis, ultimately can lead to hepatocellular carcinoma (HCC). There are currently very few approved therapies for MASH. Weight loss strategies such caloric restriction ameliorate harmful effect MASH inhibit HCC; however, it difficult implement maintain daily life, especially individuals diagnosed with HCC. In this study, we tested a time-restricted feeding (TRF) nutritional intervention mouse models We show that TRF abrogated dysregulation induced diet without any calorie or weight loss. improved insulin sensitivity reduced hyperinsulinemia, steatosis, fibrosis. Importantly, inhibited tumors two obesity-driven Our data suggest likely be effective abrogating HCC warrant further studies eating humans who at higher risk developing

Язык: Английский

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The Diurnal Transcriptome Reveals the Reprogramming of Lung Adenocarcinoma Cells Under a Time-Restricted Feeding-Mimicking Regimen

Journal of Nutrition, Год журнала: 2023, Номер 154(2), С. 354 - 368

Опубликована: Дек. 6, 2023

Язык: Английский

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The Function of Circadian Rhythm in Breast Carcinoma and Lung Carcinoma

MedScien, Год журнала: 2024, Номер 1(7)

Опубликована: Июнь 6, 2024

With the advent of electricity, people’s nightlife is gradually enriched. The prevalence late nights which disturbance circadian rhythm has raised concerns about potential risk cancer. A low quality sleep decreases immunity, distracts attention, and weakens memory. This paper going to review previous research discuss scientist’s attitudes on in By targeting clock gene, scientists have found that both mammary gland lung are affected by rhythm. Scientists execute working times shift workers their health, duration people, effect genes tumor cells. After analyzing result, this study believes long term, can be one cancer factors. To address possible factors, examines influence breast

Язык: Английский

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Autonomous Oscillatory Mitochondrial Respiratory Activity: Results of a Systematic Analysis Show Heterogeneity in Different In Vitro-Synchronized Cancer Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7797 - 7797

Опубликована: Июль 16, 2024

Circadian oscillations of several physiological and behavioral processes are an established process in all the organisms anticipating geophysical changes recurring during day. The time-keeping mechanism is controlled by a transcription translation feedback loop involving set well-characterized factors. synchronization cells, at organismal level brain central clock, can be mimicked vitro, pointing to notion that cells endowed with autonomous system. Metabolism undergoes circadian control, including mitochondrial terminal catabolic pathways, culminating under aerobic conditions electron transfer oxygen through respiratory chain coupled ATP synthesis according oxidative phosphorylation chemiosmotic mechanism. In this study, we expanded upon previous isolated observations utilizing multiple cell types, employing various protocols different methodologies measure consumption rates simulating metabolic stressors. results obtained clearly demonstrate activity rhythmic tested regardless their individual proficiency, indicating phenomenon generalized. However, notably, while primary types exhibited similar profiles, cancer-derived lines displayed highly heterogeneous changes. This observation confirms on one hand dysregulation control metabolism observed cancer, likely contributing its development, other underscores necessity personalized chronotherapy, which necessitates detailed characterization cancer chronotype.

Язык: Английский

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Causal relationships between basal metabolic rate and epigenetic age acceleration: bidirectional Mendelian randomization and mediation analysis

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Background Basal metabolic rate (BMR) reflecting the body's energy expenditure at rest, may be a crucial indicator of accelerated aging. However, there is lack evidence for causal effect BMR on We aimed to apply Mendelian randomization (MR) and mediation analysis explore relationships between epigenetic age acceleration. Method Genetic variants linked (GrimAge, PhenoAge, HannumAge HorvathAge) acceleration were extracted from genome-wide association study datasets. MR primarily utilizes Inverse variance weighted (IVW), followed by range sensitivity analyses validate robustness our findings. Results The univariable demonstrated significant GrimAge (IVW: Beta 0.38 [95% CI 0.12 0.64]), PhenoAge accelerations 0.91 [95%CI 0.67 1.45]), but not in reverse direction. In multivariate adjusting body mass index (BMI), hypertension, type 2 diabetes mellitus (T2D), physical activity, smoking, alcohol intake frequency, total bioavailable testosterone levels, we found that effects both dependent BMI, also T2D, levels Mediation indicated 7.24%, 16.29%, 6.95%, 5.36% was mediated activity intake. Conclusion A positive unidirectional acceleration, which BMI.

Язык: Английский

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Mechanisms by Which Pharmacotherapy May Impact Cancer Risk among Individuals with Overweight and Obesity

Cancers, Год журнала: 2024, Номер 16(19), С. 3275 - 3275

Опубликована: Сен. 26, 2024

Diets geared to reduce cancer risk in overweight and obese individuals focus on (1) caloric restriction (every day, some days, or most hours of each day); (2) changes macronutrient intake; (3) a combination the prior two strategies. generally fail because nonadherence due limited sustained weight loss. This is contrast diet supplemented with loss medication, so long as participant continues medication after bariatric surgery, which adherence tends be much higher. Among who regain medications are proving beneficial maintaining Both maximum essential for all forms effective metabolic improvement, including reduction. The this report assess state research consequence pharmacotherapy use proposed loss-independent effects subsequent reduction, potential role conjunction (bariatric) surgery (MBS). Finally, we present Notices Funding Opportunities (NOFOs) by National Cancer Institute (NCI) better understand mechanism(s) that driving efficacy

Язык: Английский

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Dietary Rhythms and MASLD-Related Hepatocellular Carcinoma

Cancers, Год журнала: 2024, Номер 16(20), С. 3481 - 3481

Опубликована: Окт. 14, 2024

Dietary rhythms have emerged as a relevant variable in the equation relating nutrition and health. Both experimental epidemiological studies point to potential beneficial effects of adequate fasting intervals between meals on evolution chronic diseases associated with aging. Metabolic dysfunction-associated steatotic liver disease (MASLD) is eminently related diet unsurprisingly, diet-based approaches are mainstay countering its long-term clinical evolution, including emergence hepatocellular carcinoma (HCC). We briefly discuss current evidence linking intervals, MASLD, HCC propose working hypothesis reconcile some apparently conflicting results. This relates time-restricted eating schedules quantity quality food, it easily amenable testing.

Язык: Английский

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