Toxicology in Vitro, Год журнала: 2023, Номер 91, С. 105627 - 105627
Опубликована: Июнь 12, 2023
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.
Язык: Английский
Процитировано
49
Pharmacological Research, Год журнала: 2024, Номер 200, С. 107056 - 107056
Опубликована: Янв. 15, 2024
Sepsis is a dysregulated response to infection that can result in life-threatening organ failure, and septic cardiomyopathy serious complication involving ferroptosis. Olaparib, classic targeted drug used oncology, has demonstrated potential protective effects against sepsis. However, the exact mechanisms underlying its action remain be elucidated. In our study, we meticulously screened ferroptosis genes associated with sepsis, conducted comprehensive functional enrichment analyses delineate relationship between mitochondrial damage. Eight sepsis-characterized were identified sepsis patients, including DPP4, LPIN1, PGD, HP, MAPK14, POR, GCLM, SLC38A1, which significantly correlated quality imbalance. Utilizing DrugBank molecular docking, robust interaction of Olaparib these genes. Lipopolysaccharide (LPS)-stimulated HL-1 cells monocytes establish an vitro model. Additionally, vivo model was developed using mice subjected cecal ligation perforation (CLP). Intriguingly, low-dose (5 mg/kg) effectively mitigated markers ferroptosis, concurrently improving quality. This led marked enhancement cardiac function significant increase survival rates (p < 0.05). The mechanism through ameliorates leukocyte post-sepsis attributed facilitation mitophagy, thus favoring integrity. conclusion, findings suggest improve by accelerating mitophagy flux, consequently inhibiting preserving after
Язык: Английский
Процитировано
19
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 382 - 395
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
4
Chemical Engineering Journal, Год журнала: 2023, Номер 468, С. 143685 - 143685
Опубликована: Май 22, 2023
Язык: Английский
Процитировано
32
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Окт. 20, 2023
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor type that malignant, invasive, and recurrent. Ferroptosis unique mode of programmed cell death (PCD) at the morphological, physiological, molecular levels, mainly characterized by induced iron-dependent accumulation lipid peroxides, which plays substantial role in variety diseases, including tumors inflammatory diseases. TNBC cells have been reported to display peculiar equilibrium metabolic profile iron glutathione, may increase sensitivity ferroptosis. possesses higher ferroptosis than other types. also occurred between immune cells, suggesting regulating remodel modulating response. Many ferroptosis-related genes or molecules characteristic expression patterns are expected be diagnostic targets for TNBC. Besides, therapeutic strategies based on ferroptosis, isolation extraction natural drugs use inducers, urgent personalized treatment. Thus, this review will explore contribution progression, diagnosis, treatment, provide novel perspectives management.
Язык: Английский
Процитировано
31
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Дек. 4, 2023
Diabetic nephropathy (DN) is a chronic inflammatory disease that affects millions of diabetic patients worldwide. The key to treating DN early diagnosis and prevention. Once the patient enters clinical proteinuria stage, renal damage difficult reverse. Therefore, developing treatment methods critical. pathogenesis results from various factors, among which immune response inflammation play major roles. Ferroptosis newly discovered type programmed cell death characterized by iron-dependent lipid peroxidation excessive ROS production. Recent studies have demonstrated activation closely related occurrence development ferroptosis. Moreover, hyperglycemia induces iron overload, peroxidation, oxidative stress, inflammation, fibrosis, all are pathogenesis, indicating ferroptosis plays role in DN. this review focuses on regulatory mechanisms ferroptosis, mutual processes involved inflammation. By discussing analyzing relationship between DN, we can deepen our understanding develop new therapeutics targeting or inflammation-related for with
Язык: Английский
Процитировано
26
Redox Biology, Год журнала: 2024, Номер 73, С. 103179 - 103179
Опубликована: Май 8, 2024
Increasing evidences demonstrate that environmental stressors are important inducers of acute kidney injury (AKI). This study aimed to investigate the impact exposure Cd, an stressor, on renal cell ferroptosis. Transcriptomics analyses showed arachidonic acid (ARA) metabolic pathway was disrupted in Cd-exposed mouse kidneys. Targeted metabolomics oxidized ARA metabolites were increased mice. Renal 4-HNE, MDA, and ACSL4, upregulated Consistent with animal experiments, vitro experiments mitochondrial lipids elevated HK-2 cells. Ultrastructure membrane rupture Mitochondrial cristae accordingly reduced SIRT3, NAD
Язык: Английский
Процитировано
15
Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 201, С. 105904 - 105904
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
12
Renal Failure, Год журнала: 2024, Номер 46(2)
Опубликована: Июль 31, 2024
Objective Sirt6, reactive oxygen species and ferroptosis may participate in the pathogenesis of Diabetic Nephropathy (DN). Exploring relationship between oxidative stress, provides new scientific ideas to DN.
Язык: Английский
Процитировано
12
Cell Death Discovery, Год журнала: 2023, Номер 9(1)
Опубликована: Июль 12, 2023
Abstract Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function that results increased resistance arterial pressure, it characterized endothelial dysfunction, artery media thickening, remodeling, right ventricular hypertrophy, all of which are driven an imbalance between the growth death cells. Programmed cell (PCD), different from necrosis, active cellular mechanism activated response to both internal external factors precisely regulated More than dozen PCD modes have been identified, among apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis, cuproptosis proven be involved pathophysiology PH varying degrees. This article provides summary regulatory patterns their potential effects on PH. Additionally, describes current understanding this complex interconnected process analyzes therapeutic targeting specific as molecular targets.
Язык: Английский
Процитировано
19