Disrupted Sleep and Circadian Rhythms in Schizophrenia and Their Interaction With Dopamine Signaling DOI Creative Commons
Anna Ashton, Aarti Jagannath

Frontiers in Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Июнь 23, 2020

Sleep and circadian rhythm disruption (SCRD) is a common feature of schizophrenia, associated with symptom severity patient quality life. It commonly manifested as disturbances to the sleep/wake cycle, sleep abnormalities occurring in up 80% patients, making it one most symptoms this disorder. Severe misalignment has also been reported, including non-24 h periods phase advances delays. In parallel, there are alterations physiological parameters such body temperature rhythmic hormone production. At molecular level, expression core clock genes indicate dysfunctional clock. Furthermore, genetic association studies have demonstrated that mutations several higher risk schizophrenia. Collectively, evidence strongly suggests not only schizophrenia but plays an important causal role The dopamine signaling occur likely be central role. Dopamine well-documented involved regulation which acts promote wakefulness, elevated levels can disturb sleep. There for influence on clock, through entrainment master suprachiasmatic nuclei (SCN), itself under control. Therefore closely linked system; appears they complex, bidirectional relationship pathogenesis exacerbate other. This review will provide overview SCRD examine interplay altered signaling. We assess suggest underlying mechanisms sleep/circadian rhythms pathophysiology Improvements improvements symptoms, along life measures cognitive ability employability. system holds valuable potential new therapeutic target

Язык: Английский

Functional catalytic nanoparticles (nanozymes) for sensing DOI
Yu Ouyang, Michael O’Hagan, Itamar Willner

и другие.

Biosensors and Bioelectronics, Год журнала: 2022, Номер 218, С. 114768 - 114768

Опубликована: Окт. 3, 2022

Язык: Английский

Процитировано

73
Neurotransmitters in Prevention and Treatment of Alzheimer’s Disease DOI Open Access
Zhenqi Yang,

Yong Zou,

Lifeng Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3841 - 3841

Опубликована: Фев. 14, 2023

Alzheimer’s disease (AD) is the most frequent cause of cognitive impairment in middle-aged and older populations. There a lack drugs that demonstrate significant efficacy AD, so study pathogenesis AD great importance. More efficacious interventions are needed, as reflected by our population’s fast aging. Synaptic plasticity capacity neurons to adjust their connections, it strongly tied learning memory, function, brain injury recovery. Changes synaptic strength, such long-term potentiation (LTP) or inhibition (LTD), thought represent biological foundation early stages memory. The results numerous studies confirm neurotransmitters receptors play an important role regulation plasticity. However, far, there no definite correlation between function aberrant neural oscillation AD-related impairment. We summarized process understand impact progression including current status neurotransmitter target drugs, latest evidence neurotransmitters’ changes process.

Язык: Английский

Процитировано

53
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases DOI

Elena Possemato,

Livia La Barbera, Annalisa Nobili

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101907 - 101907

Опубликована: Март 8, 2023

Язык: Английский

Процитировано

45
The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights DOI Open Access
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci

и другие.

Nutrients, Год журнала: 2023, Номер 15(6), С. 1496 - 1496

Опубликована: Март 20, 2023

There is growing interest in the role that intestinal microbiota and related autoimmune processes may have genesis presentation of some psychiatric diseases. An alteration communication microbiota-gut-brain axis, which constitutes a communicative model between central nervous system (CNS) gastro-enteric tract, has been identified as one possible causes The purpose this narrative review to describe evidence supporting gut diseases impact diet on mental health. Change composition could determine an increase permeability barrier, leading cytokine storm. This trigger systemic inflammatory activation immune response: series events repercussions release neurotransmitters, altering activity hypothalamic-pituitary-adrenal reducing presence trophic brain factors. Although disorders seem be connected, more effort needed understand potential causative mechanisms underlying interactions these systems.

Язык: Английский

Процитировано

45
The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review DOI Creative Commons
Amjad Mhanna, Nafiza Martini, Ghefar Hmaydoosh

и другие.

Medicine, Год журнала: 2024, Номер 103(5), С. e37114 - e37114

Опубликована: Фев. 2, 2024

The gastrointestinal tract is embedded with microorganisms of numerous genera, referred to as gut microbiota. Gut microbiota has multiple effects on many body organs, including the brain. There a bidirectional connection between and brain called gut-brain-axis, these connections are formed through immunological, neuronal, neuroendocrine pathways. In addition, modulates synthesis functioning neurotransmitters. Therefore, disruption in composition or function, which known dysbiosis, associated pathogenesis mental disorders, such schizophrenia, depression, other psychiatric disorders. This review aims summarize modulation role 4 prominent neurotransmitters (tryptophan serotonergic system, dopamine, gamma-aminobutyric acid, glutamate), well its association disorders (schizophrenia, anxiety autism spectrum disorder). More future research required develop efficient gut-microbiota-based therapies for illnesses.

Язык: Английский

Процитировано

41
Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain DOI Creative Commons
Simone Battaglia, Claudio Nazzi, Julian F. Thayer

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 15, 2024

Abstract Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is physiological index observable in humans, especially fear conditioning experiments. While gaining interest recent years, it still currently underemployed neuroscientific research compared more popular indices. Besides its use research, could also constitute valuable resource clinical psychiatry setting, as many disorders are characterized by altered heart rate responses. However, differences fear-induced bradycardia may be subtended genetic interindividual differences, thus suggesting precaution when recommending the setting. Here, we discussed first endeavors that aimed at clarifying underpinnings of variations, which suggest individual have role defining characteristics Given this, translating measurements setting must implemented with caution. Future this field will aim identifying these even further, allowing for precise interventions.

Язык: Английский

Процитировано

29
Atrazine’s effects on mammalian physiology DOI Creative Commons

Anna G. Holliman,

Laci Mackay,

Vinicia C. Biancardi

и другие.

Journal of Toxicology and Environmental Health Part B, Год журнала: 2025, Номер unknown, С. 1 - 40

Опубликована: Фев. 27, 2025

Atrazine is a chlorotriazine herbicide that one of the most widely used herbicides in USA and world. For over 60 years atrazine has been on major crops including corn, sorghum, sugarcane to control broadleaf grassy weed emergence growth. exerted economic environmental impact time, resulting reduced production costs increased conservation tillage practices. However, widespread use long half-life led high prevalence environment. Indeed, frequent contaminant detected water sources USA. Due its almost ubiquitous presence questions regarding safety, well-studied. First reported affect reproduction with potential disruptive effects which were later linked immune system, cancer, stress response, neurological disorders, cardiovascular ailments experimental models. multiple interwoven systems broadens significance exposure. The endeavor uncover mechanisms underlying atrazine-induced dysfunction mammals ongoing, new genetic pharmacological targets being reported. This review aims summarize prominent mammalian physiology, primarily focusing empirical studies conducted lab animal models establish correlations epidemiological human when relevant. In addition, current common patterns toxicity action will be examined.

Язык: Английский

Процитировано

3
Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications DOI Creative Commons
Anna V. Leopold, Daria M. Shcherbakova, Vladislav V. Verkhusha

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2019, Номер 13

Опубликована: Окт. 23, 2019

Understanding how neuronal activity patterns in the brain correlate with complex behavior is one of primary goals modern neuroscience. Chemical transmission major way communication between neurons; however, traditional methods detection neurotransmitter and neuromodulator transients mammalian lack spatiotemporal precision. Modern fluorescent biosensors for neurotransmitters neuromodulators allow monitoring chemical vivo millisecond precision single cell resolution. Changes biosensor brightness occur upon binding can be detected using fiber photometry, stationary microscopy miniaturized head-mounted microscopes. Biosensors expressed animal adeno-associated viral vectors, their cell-specific expression achieved Cre-recombinase expressing animals. Although initially were represented by glutamate biosensors, nowadays GABA, acetylcholine, glycine, norepinephrine dopamine are available as well. In this review, we overview functioning principles existing intensiometric ratiometric provide brief insight into variety neurotransmitter-binding proteins from bacteria, plants eukaryotes including G-protein coupled receptors, which may serve scaffolds. We next describe a workflow development biosensors. then discuss advanced setups functional imaging awake freely moving conclude providing application examples studies single-neuron

Язык: Английский

Процитировано

105
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.) DOI
Ajay Kumar,

Sajana Sreedharan,

Arun Kumar Kashyap

и другие.

Heliyon, Год журнала: 2021, Номер 8(1), С. e08669 - e08669

Опубликована: Дек. 27, 2021

Язык: Английский

Процитировано

93
Dopamine: an immune transmitter DOI Creative Commons
Alessandro Castorina, Sarah Thomas Broome,

Krystal Louangaphay

и другие.

Neural Regeneration Research, Год журнала: 2020, Номер 15(12), С. 2173 - 2173

Опубликована: Янв. 1, 2020

The dopaminergic system controls several vital central nervous functions, including the control of movement, reward behaviors and cognition. Alterations signaling are involved in pathogenesis neurodegenerative psychiatric disorders, particular Parkinson’s disease, which associated with a subtle chronic inflammatory response. A substantial body evidence has demonstrated non-neuronal expression dopamine, its receptors machinery that governs synthesis, secretion storage dopamine across immune cell types. This review aims to summarize current knowledge on role cells. One goals is decipher complex mechanisms through these types respond order address impact this pathologies such as disease. further aim illustrate gaps our understanding physiological roles encourage more targeted research focused consequences aberrant production regulation. These highlights may prompt scientists field consider alternative functions important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.

Язык: Английский

Процитировано

91