Abstract
Research
on
serotonin
reveals
a
lack
of
consensus
regarding
its
role
in
brain
volume,
especially
concerning
biomarkers
linked
to
neurogenesis
and
neuroplasticity,
such
as
ciliary
neurotrophic
factor
(CNTF),
fibroblast
growth
4
(FGF-4),
bone
morphogenetic
protein
6
(BMP-6),
matrix
metalloproteinase-1
(MMP-1)
Alzheimer’s
disease
(AD).
This
study
aimed
investigate
the
influence
structure
hippocampal
volumes
relation
cognitive
functions
AD,
well
link
with
like
CNTF,
FGF-4,
BMP-6,
MMP-1.
Data
from
133
ADNI
participants
AD
included
assessments
(CDR-SB),
measurements
(Biocrates
AbsoluteIDQ
p180
kit,
UPLC-MS/MS),
factors
quantified
via
multiplex
proteomics.
Gray
matter
volume
changes
were
analyzed
using
Voxel-Based
Morphometry
(VBM)
MRI.
Statistical
analyses
employed
Pearson
correlation,
bootstrap
methods,
FDR-adjusted
p-values
(<
0.05
or
<
0.01)
Benjamini–Hochberg
procedure,
alongside
nonparametric
methods.
The
analysis
found
positive
correlation
between
levels
total
(r
=
0.229,
p
0.023)
(right:
r
0.186,
0.032;
left:
0.210,
0.023),
even
after
FDR
adjustment.
Higher
better
function
(negative
CDR-SB,
−0.230,
0.024).
Notably,
positively
correlated
BMP-6
0.173,
0.047),
CNTF
0.216,
0.013),
FGF-4
0.176,
0.043),
MMP-1
0.202,
0.019),
suggesting
neuroplasticity.
However,
adjusting
for
multiple
comparisons
controlling
confounding
age,
gender,
education,
APOE
genotypes
(APOE3
APOE4),
none
correlations
remained
statistically
significant.
In
conclusion,
increased
are
associated
improved
volume.
associations
not
significant
adjustments,
highlighting
complexity
serotonin’s
need
further
research.
Graphical
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(5), С. 2097 - 2117
Опубликована: Март 5, 2024
Currently,
one
of
the
most
significant
and
rapidly
growing
unmet
medical
challenges
is
treatment
neurodegenerative
diseases
such
as
Alzheimer's
disease
(AD)
Parkinson's
(PD).
This
challenge
encompasses
imperative
development
efficacious
therapeutic
agents
overcoming
intricacies
blood–brain
barrier
for
successful
drug
delivery.
Here
we
focus
on
delivery
aspect
with
particular
emphasis
cell-penetrating
peptides
(CPPs),
widely
used
in
basic
translational
research
they
enhance
to
challenging
targets
tissue
cellular
compartments
thus
increase
efficacy.
The
combination
CPPs
nanomaterials
nanoparticles
(NPs)
improves
performance,
accuracy,
stability
enables
higher
loads.
Our
review
presents
discusses
that
utilizes
CPPs,
either
alone
or
conjugation
NPs,
mitigate
pathogenic
effects
reference
AD
PD.
Pharmaceutics,
Год журнала:
2023,
Номер
15(8), С. 2052 - 2052
Опубликована: Июль 31, 2023
Alzheimer
disease
(AD)
is
the
most
prevalent
form
of
dementia
among
elderly
people.
Owing
to
its
varied
and
multicausal
etiopathology,
intervention
strategies
have
been
highly
diverse.
Despite
ongoing
advances
in
field,
efficient
therapies
mitigate
AD
symptoms
or
delay
their
progression
are
still
limited
scope.
Neuroplasticity,
broad
terms
ability
brain
modify
structure
response
external
stimulation
damage,
has
received
growing
attention
as
a
possible
therapeutic
target,
since
disruption
plastic
mechanisms
appear
correlate
with
various
forms
cognitive
impairment
present
patients.
Several
pre-clinical
clinical
studies
attempted
enhance
neuroplasticity
via
different
mechanisms,
for
example,
regulating
glucose
lipid
metabolism,
targeting
activity
neurotransmitter
systems,
addressing
neuroinflammation.
In
this
review,
we
first
describe
several
structural
functional
aspects
neuroplasticity.
We
then
focus
on
current
status
pharmacological
approaches
stemming
from
trials
neuroplastic
This
followed
by
an
analysis
analogous
interventions
animal
models,
according
action.
Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Год журнала:
2025,
Номер
15(1), С. 264 - 278
Опубликована: Фев. 19, 2025
Molecular
docking
is
a
computational
modeling
technique
that
predicts
the
interactions
between
molecules
of
interest
and
certain
protein
structures.
This
approach
estimates
binding
affinities
visualizes
bond
interactions,
making
it
useful
tool
for
drug
discovery.
helps
to
rationally
design
new
therapeutic
medicines
by
offering
insight
into
potential
connections
molecular
structures
prior
laboratory
testing.
ADME
investigations
supplement
assessing
pharmacokinetic
features
examined
compounds,
consequently
determining
their
eligibility
as
possible
candidates.
In
this
study,
we
show
creative
design,
synthesis,
silico
evaluation
novel
series
bis-ureido
substituted
antipyrine
derivatives,
with
focus
on
cholinesterase
inhibitors.
Using
tools,
combined
group
improve
pharmacological
properties
these
molecules.
The
newly
synthesized
compounds
were
comprehensively
characterized
spectroscopic
approaches,
including
FT-IR,
¹H-NMR,
¹³C-NMR,
followed
experiments
analyze
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BChE).
Additionally,
assessments
performed
determine
compounds'
characteristics
drug-likeness
properties.
Notably,
compound
10
showed
strong
against
AChE
BChE,
energies
-14.47
-11.75
kcal/mol,
respectively.
data
revealed
high
affinities,
indicating
significant
inhibitory
both
BChE.
study
points
out
need
combining
in
contemporary
pharmaceutical
development.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 6928 - 6928
Опубликована: Июнь 25, 2024
Air
pollution,
a
growing
concern
for
public
health,
has
been
linked
to
various
respiratory
and
cardiovascular
diseases.
Emerging
evidence
also
suggests
link
between
exposure
air
pollutants
neurodegenerative
diseases,
particularly
Alzheimer's
disease
(AD).
This
review
explores
the
composition
sources
of
pollutants,
including
particulate
matter,
gases,
persistent
organic
heavy
metals.
The
pathophysiology
AD
is
briefly
discussed,
highlighting
role
beta-amyloid
plaques,
neurofibrillary
tangles,
genetic
factors.
article
examines
how
reach
brain
exert
their
detrimental
effects,
delving
into
neurotoxicity
pollutants.
molecular
mechanisms
linking
pollution
neurodegeneration
are
explored
in
detail,
focusing
on
oxidative
stress,
neuroinflammation,
protein
aggregation.
Preclinical
studies,
vitro
experiments
animal
models,
provide
direct
effects
neuronal
cells,
glial
blood-brain
barrier.
Epidemiological
studies
have
reported
associations
an
increased
risk
cognitive
decline.
body
supporting
as
modifiable
factor
underscores
importance
considering
environmental
factors
etiology
progression
face
worsening
global
quality.
