Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 21, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
malignant
tumor
originating
from
epithelial
cells
of
the
colon
or
rectum,
and
its
invasion
metastasis
could
be
regulated
by
anoikis.
However,
key
genes
pathways
regulating
anoikis
in
CRC
are
still
unclear
require
further
research.
The
single
cell
transcriptome
dataset
GSE221575
GEO
database
was
downloaded
applied
to
subpopulation
type
identification,
intercellular
communication,
pseudo
time
trajectory
analysis,
receptor
ligand
expression
analysis
CRC.
Meanwhile,
RNA
TCGA,
GSE39582,
GSE17536,
GSE17537
datasets
were
merged
into
one
bulk
dataset.
differentially
expressed
(DEGs)
related
extracted
these
data
sets,
marker
obtained
after
feature
selection.
A
clinical
prognosis
prediction
model
constructed
based
on
predictive
effect
analyzed.
Subsequently,
gene
pathway
immune
infiltration
immunosuppressive
point
drug
sensitivity
immunotherapy
efficacy
conducted
for
model.
In
this
study,
we
used
determine
activity
analyzed
DEGs
score
identify
involved
disease
After
dimensionality
reduction
selection,
7
obtained,
including
TIMP1,
VEGFA,
MYC,
MSLN,
EPHA2,
ABHD2
,
CD24
.
prognostic
risk
scoring
system
built
genes,
along
with
patient
(age,
stage,
grade),
incorporated
create
nomogram,
which
predicted
1-,
3-,
5-years
survival
accuracy
0.818,
0.821,
0.824.
By
using
system,
samples
divided
high/low
anoikis-related
groups,
there
significant
differences
infiltration,
distribution
checkpoints,
chemotherapy
drugs,
between
two
groups.
Anoikis
participate
differentiation
colorectal
cells,
promote
development,
predict
cancer.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Окт. 2, 2023
Cancer
stem
cells
(CSCs)
have
emerged
as
key
contributors
to
tumor
initiation,
growth,
and
metastasis.
In
addition,
CSCs
play
a
significant
role
in
inducing
immune
evasion,
thereby
compromising
the
effectiveness
of
cancer
treatments.
The
reciprocal
communication
between
microenvironment
(TME)
is
observed,
with
TME
providing
supportive
niche
for
CSC
survival
self-renewal,
while
CSCs,
turn,
influence
polarization
persistence
TME,
promoting
an
immunosuppressive
state.
Consequently,
these
interactions
hinder
efficacy
current
therapies,
necessitating
exploration
novel
therapeutic
approaches
modulate
target
CSCs.
this
review,
we
highlight
intricate
strategies
employed
by
evade
surveillance
develop
resistance
therapies.
Furthermore,
examine
dynamic
interplay
shedding
light
on
how
interaction
impacts
progression.
Moreover,
provide
overview
advanced
that
specifically
which
hold
promise
future
clinical
translational
studies
treatment.
The
extracellular
matrix
(ECM)
governs
a
wide
spectrum
of
cellular
fate
processes,
with
particular
emphasis
on
anoikis,
an
integrin-dependent
form
cell
death.
Currently,
anoikis
is
defined
as
intrinsic
apoptosis.
In
contrast
to
traditional
apoptosis
and
necroptosis,
integrin
correlates
ECM
signaling
intracellular
cascades,
describing
the
full
process
anoikis.
However,
frequently
overlooked
in
physiological
pathological
processes
well
vitro
research
models.
this
review,
we
summarized
role
spanning
embryonic
development,
organ
tissue
repair,
inflammatory
responses,
cardiovascular
diseases,
tumor
metastasis,
so
on.
Similarly,
realm
stem
focused
functional
evolution
cells,
offers
potential
solution
various
challenges,
including
culture
models,
therapy,
transplantation,
engineering
applications,
which
are
largely
based
regulation
by
More
importantly,
regulatory
mechanisms
molecular
will
provide
new
strategies
for
therapeutic
interventions
(drug
therapy
cell-based
therapy)
disease.
summary,
review
provides
systematic
elaboration
thus
shedding
light
its
future
research.
Current Molecular Medicine,
Год журнала:
2023,
Номер
24(6), С. 702 - 711
Опубликована: Май 19, 2023
Abstract:
Natural
remedies
from
a
range
of
sources,
including
plants,
animals,
microorganisms,
and
marine
life,
have
made
significant
contribution
to
the
treatment
many
ailments.
Lavender
is
Mediterranean
shrub
Lamiaceae
family.
flowers
(Lavandula
flores)
include
active
ingredients
(3%),
anthocyanins,
sugars,
phytosterols,
minerals,
tannins
are
majorly
used
for
herbal
applications.
essential
oil's
descriptive
analytical
composition
varies
depending
on
genotype,
growing
region,
climatic
circumstances,
propagation,
morphological
characteristics.
There
around
300
chemical
components
in
oil.
Linalool,
terpinen-4-ol,
linalyl
acetate,
ocimene,
acetate
lavandulol,
cineole
most
prominent
constituents.
oil
has
antibacterial
antioxidant
properties.
The
lavender
extract
helps
prevent
dementia
may
slow
cancer
cell
growth,
while
treat
skin
problems.
This
review
will
cover
recent
medical,
economic
regional
advancements
levander
propagation
how
Council
Scientific
&
Industrial
Research
Indian
Institute
Integrative
(CSIR
IIIM)
aroma
mission
actively
acting
as
bridge
between
farmers
their
improvement
by
attracting
them
field
medicinal
plant
cultivation.
