Molecular Diversity, Год журнала: 2024, Номер unknown
Опубликована: Окт. 9, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Ноя. 29, 2023
Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract
Язык: Английский
Процитировано
29
Drug Development Research, Год журнала: 2023, Номер 84(5), С. 907 - 921
Опубликована: Апрель 18, 2023
Nonsmall cell lung cancer (NSCLC) is the main type of cancer, accounting for approximately 85%. Berberine (BBR), a commonly used traditional Chinese medicine, has been reported to exhibit potential antitumor effect in various cancers. In this research, we explored function BBR and its underlying mechanisms development NSCLC.Cell Counting Kit-8 (CCK-8), 5-ethynyl-20-deoxyuridine (EdU), colony formation assays, flow cytometry, transwell invasion assay were employed determine growth, apoptotic rate, NSCLC cells, respectively. Western blot was applied detecting protein expression c-Myc, matrix metalloprotease 9 (MMP9), kinesin family member 20A (KIF20A), cyclin E2 (CCNE2), phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway-related proteins. Glycolysis evaluated by glucose consumption, lactate production, adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio with matched kits. Real-time quantitative polymerase chain reaction (RT-qPCR) conducted analyze level KIF20A CCNE2. Tumor model established evaluate on tumor growth vivo. addition, immunohistochemistry detect KIF20A, CCNE2, MMP9 mice tissues.BBR exhibited suppressive effects progression NSCLC, as evidenced inhibiting invasion, glycolysis, facilitating apoptosis H1299 A549 cells. CCNE2 upregulated tissues Moreover, treatment significantly decreased or downregulation could repress proliferation, induce both The inhibition promotion rescued overexpression inactivation PI3K/AKT pathway caused cells restored upregulation. vivo experiments also demonstrated that regulating inactivating pathway.BBR showed impact targeting thereby activation pathway.
Язык: Английский
Процитировано
17
Brain Research Bulletin, Год журнала: 2025, Номер 221, С. 111189 - 111189
Опубликована: Янв. 5, 2025
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) the commonest type of focal in adults that resist to conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect epileptogenesis and progression disease. Therefore, repurposing natural products with anti-inflammatory, anti-oxidant effects such as berberine (BRB) may be logical treating refractory TLE. However, molecular mechanism BRB against development seizure mainly TLE was fully elucidated. we attempt this review discuss potential underlying
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2022, Номер 15(11), С. 1361 - 1361
Опубликована: Ноя. 7, 2022
Type 2 diabetes mellitus (T2DM) is a potential risk factor for the development of COVID-19 and associated with higher severity mortality rates. T2DM patients are commonly treated metformin monotherapy or plus sitagliptin. In present case-control, single-center cohort study, total number 112 suffering from aged 44−62 years old were compared 78 without 42−56 old. Both patient group control allocated into four groups. Group A: on treatments standard therapy (n = 60); B: sitagliptin 52); C: 40); D: 38). The investigation duration was 2−3 weeks. Anthropometric measurements, serological biochemical investigations, pulmonary radiological findings, clinical outcomes evaluated. Only 101 continued 71 (70.29%) mild-moderate 30 (29.7%) severe as control. Inflammatory biomarkers (C reactive protein, ferritin, procalcitonin), lung injury biomarker (lactate dehydrogenase), coagulopathy (D-dimer) elevated in (p < 0.05) 0.05). However, more effective than COVID-19, evidenced by mitigation oxidative stress, CT scan score, outcomes. study confirmed protective effects this combination against severity, most develop forms. Herein, may lead to beneficial monotherapy.
Язык: Английский
Процитировано
25
Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(5), С. 1267 - 1278
Опубликована: Июль 3, 2023
Acute ischemic stroke (AIS) is a focal neurological disorder that accounts for 85% of all types, due to occlusion cerebral arteries by thrombosis and emboli. AIS also developed hemodynamic abnormality. associated with the development neuroinflammation which increases severity AIS. Phosphodiesterase enzyme (PDEs) inhibitors have neuro-restorative neuroprotective effects against through modulation cyclic adenosine monophosphate (cAMP)/cyclic guanosine (cGMP)/nitric oxide (NO) pathway. PDE5 mitigation may decrease risk long-term AIS-induced complications. affect properties coagulation pathway are thrombotic complications in reduce activation pro-coagulant improve microcirculatory level patients disturbances mainly tadalafil sildenafil clinical outcomes regulation perfusion blood flow (CBF). reduced thrombomodulin, P-selectin, tissue plasminogen activator. Herein, In conclusion, potential roles management CBF, cAMP/cGMP/NO pathway, neuroinflammation, inflammatory signaling pathways. Preclinical studies recommended this regard.
Язык: Английский
Процитировано
17
Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 478(10), С. 2271 - 2279
Опубликована: Янв. 18, 2023
Язык: Английский
Процитировано
14
Chemico-Biological Interactions, Год журнала: 2023, Номер 386, С. 110731 - 110731
Опубликована: Окт. 13, 2023
Язык: Английский
Процитировано
12
Clinical and Experimental Pharmacology and Physiology, Год журнала: 2023, Номер 50(5), С. 335 - 352
Опубликована: Фев. 3, 2023
Abstract Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca 2+ release from stores in the sarcoplasmic reticulum. DTN mainly used management of malignant hyperthermia. RyRs are highly expressed immune cells and involved different viral infections, including severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), because necessary for replication, maturation release. can inhibit proliferation SARS‐CoV‐2, indicating its potential role reducing entry pathogenesis SARS‐CoV‐2. may increase clearance SARS‐CoV‐2 promote disease 2019 (COVID‐19) recovery by shortening period infection. N‐methyl‐D‐aspartate (NMDA) mediated platelets aggregations thrombosis. Therefore, thrombosis coagulopathy COVID‐19 through suppression platelet NMDA receptors. Moreover, has neuroprotective effect against infection‐induced brain injury modulation receptors, which excitotoxicity, neuronal development neuropsychiatric disorders. In conclusion, inhibiting attenuate inflammatory disorders infection associated cardio‐pulmonary complications. DNT could be promising drug therapy COVID‐19. Preclinical clinical studies warranted this regards.
Язык: Английский
Процитировано
11
Immunity Inflammation and Disease, Год журнала: 2023, Номер 11(4)
Опубликована: Апрель 1, 2023
Coronavirus disease 2019 (Covid-19) is caused by a novel severe acute respiratory syndrome coronavirus virus type 2 (SARS-CoV-2) leading to the global pandemic worldwide. Systemic complications in Covid-19 are mainly related direct SARS-CoV-2 cytopathic effects, associated hyperinflammation, hypercytokinemia, and development of cytokine storm (CS). As well, developed due propagation oxidative thrombotic events which may progress state called (TS), respectively. In addition, inflammatory lipid storms also activation cells release bioactive lipids correspondingly. Therefore, present narrative review aimed elucidate interrelated relationship between different types mixed (MS). conclusion, infection induces various including CS, storm, TS storm. These not developing alone since there close them. MS seems be more appropriate than it develops intricate interface reactive oxygen species, proinflammatory cytokines, complement activation, coagulation disorders, activated signaling pathway.
Язык: Английский
Процитировано
11
Current Pharmacology Reports, Год журнала: 2023, Номер 9(5), С. 329 - 340
Опубликована: Авг. 26, 2023
Язык: Английский
Процитировано
11