Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117296 - 117296
Опубликована: Авг. 20, 2024
Over
the
past
decades,
cancer
immunotherapy
has
encountered
challenges
such
as
immunogenicity,
inefficiency,
and
cytotoxicity.
Consequently,
exosome-based
gained
rapid
traction
a
promising
alternative.
Exosomes,
type
of
extracellular
vesicles
(EVs)
ranging
from
50
to
150
nm,
are
self-originating
exhibit
fewer
side
effects
compared
traditional
therapies.
Exosome-based
encompasses
three
significant
areas:
vaccination,
co-inhibitory
checkpoints,
adoptive
T-cell
therapy.
Each
these
fields
leverages
inherent
advantages
exosomes,
demonstrating
substantial
potential
for
individualized
tumor
therapy
precision
medicine.
This
review
aims
elucidate
reasons
behind
promise
nanoparticles
therapies
by
examining
their
characteristics
summarizing
latest
research
advancements
in
immunotherapy.
Cancer Cell International,
Год журнала:
2023,
Номер
23(1)
Опубликована: Авг. 11, 2023
Abstract
Lung
cancer
continues
to
be
the
leading
cause
of
cancer-related
death
worldwide.
In
last
decade,
significant
advancements
in
diagnosis
and
treatment
lung
cancer,
particularly
NSCLC,
have
been
achieved
with
help
molecular
translational
research.
Among
hopeful
breakthroughs
therapeutic
approaches,
advances
targeted
therapy
brought
most
successful
outcomes
NSCLC
treatment.
therapy,
antagonists
target
specific
genes,
proteins,
or
microenvironment
tumors
supporting
growth
survival.
Indeed,
can
managed
by
blocking
genes
related
tumor
cell
progression
without
causing
noticeable
damage
normal
cells.
Currently,
efforts
focused
on
improving
aspects
regarding
encouraging
quality
life
patients.
Treatment
for
is
changing
rapidly
due
pace
scientific
Accordingly,
this
updated
study
aimed
discuss
antigens
comprehensively
therapy-related
agents
NSCLC.
The
current
also
summarized
available
clinical
trial
studies
Abstract
In
recent
decades,
research
on
Extracellular
Vesicles
(EVs)
has
gained
prominence
in
the
life
sciences
due
to
their
critical
roles
both
health
and
disease
states,
offering
promising
applications
diagnosis,
drug
delivery,
therapy.
However,
inherent
heterogeneity
complex
origins
pose
significant
challenges
preparation,
analysis,
subsequent
clinical
application.
This
review
is
structured
provide
an
overview
of
biogenesis,
composition,
various
sources
EVs,
thereby
laying
groundwork
for
a
detailed
discussion
contemporary
techniques
preparation
analysis.
Particular
focus
given
state‐of‐the‐art
technologies
that
employ
microfluidic
non‐microfluidic
platforms
EV
processing.
Furthermore,
this
discourse
extends
into
innovative
approaches
incorporate
artificial
intelligence
cutting‐edge
electrochemical
sensors,
with
particular
emphasis
single
proposes
current
outlines
prospective
avenues
future
research.
The
objective
motivate
researchers
innovate
expand
methods
analysis
fully
unlocking
biomedical
potential.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 13, 2024
Exosomes,
extracellular
vesicles
secreted
by
cells,
have
garnered
significant
attention
in
recent
years
for
their
remarkable
therapeutic
potential.
These
nanoscale
carriers
can
be
harnessed
the
targeted
delivery
of
agents,
such
as
pharmaceuticals,
proteins,
and
nucleic
acids,
across
biological
barriers.
This
versatile
attribute
exosomes
is
a
promising
modality
precision
medicine
applications,
notably
realm
cancer
therapy.
However,
despite
substantial
potential,
still
confront
challenges
tied
to
standardization
scalability
that
impede
practice
clinical
applications.
Moreover,
heterogeneity
isolation
methodologies
limited
cargo
loading
mechanisms
pose
obstacles
ensuring
consistent
outcomes,
thereby
constraining
utility.
In
contrast,
exhibit
distinct
advantage
diagnosis,
they
harbor
specific
signatures
reflective
tumor's
genetic
proteomic
profile.
characteristic
endows
them
with
potential
serve
valuable
liquid
biopsies
non-invasive
real-time
monitoring,
making
possible
early
detection
development
personalized
treatment
strategies.
this
review,
we
provide
an
extensive
evaluation
advancements
exosome
research,
critically
examining
advantages
limitations
context
therapy
diagnosis.
Furthermore,
present
curated
overview
most
technological
innovations
utilizing
exosomes,
focus
on
enhancing
efficacy
detection.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 123 - 123
Опубликована: Янв. 7, 2024
Lung
cancer
demands
innovative
approaches
for
early
detection
and
targeted
treatment.
In
addressing
this
urgent
need,
exosomes
play
a
pivotal
role
in
revolutionizing
both
the
treatment
of
lung
cancer.
Their
remarkable
capacity
to
encapsulate
diverse
range
biomolecules,
traverse
biological
barriers,
be
engineered
with
specific
targeting
molecules
makes
them
highly
promising
diagnostic
markers
precise
drug
delivery
cells.
Furthermore,
an
in-depth
analysis
exosomal
content
biogenesis
offers
crucial
insights
into
molecular
profile
tumors.
This
knowledge
holds
significant
potential
development
therapies
strategies
Despite
notable
progress
field,
challenges
standardization
cargo
loading
persist.
Collaborative
research
efforts
are
imperative
maximize
advance
field
precision
medicine
benefit
patients.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(8), С. 3432 - 3456
Опубликована: Май 13, 2024
The
advent
of
cancer
immunotherapy
has
imparted
a
transformative
impact
on
treatment
paradigms
by
harnessing
the
power
immune
system.
However,
challenge
practical
and
precise
targeting
malignant
cells
persists.
To
address
this,
engineered
nanoparticles
(NPs)
have
emerged
as
promising
solution
for
enhancing
targeted
drug
delivery
in
immunotherapeutic
interventions,
owing
to
their
small
size,
low
immunogenicity,
ease
surface
modification.
This
comprehensive
review
delves
into
contemporary
research
at
nexus
NP
engineering
immunotherapy,
encompassing
an
extensive
spectrum
morphologies
strategies
tailored
toward
optimizing
tumor
augmenting
therapeutic
effectiveness.
Moreover,
it
underscores
mechanisms
that
NPs
leverage
bypass
numerous
obstacles
encountered
regimens
probes
combined
potential
when
co-administered
with
both
established
novel
modalities.
Finally,
evaluates
existing
limitations
platforms
which
could
shape
path
future
advancements
this
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4024 - 4024
Опубликована: Апрель 4, 2024
The
animal
gut
microbiota,
comprising
a
diverse
array
of
microorganisms,
plays
pivotal
role
in
shaping
host
health
and
physiology.
This
review
explores
the
intricate
dynamics
microbiome
animals,
focusing
on
its
composition,
function,
impact
host–microbe
interactions.
composition
intestinal
microbiota
animals
is
influenced
by
ecology,
including
factors
such
as
temperature,
pH,
oxygen
levels,
nutrient
availability,
well
genetic
makeup,
diet,
habitat,
stressors,
husbandry
practices.
Dysbiosis
can
lead
to
various
gastrointestinal
immune-related
issues
impacting
overall
productivity.
Extracellular
vesicles
(EVs),
particularly
exosomes
derived
from
play
crucial
intercellular
communication,
influencing
transporting
bioactive
molecules
across
barriers
like
brain
barriers.
Dysregulation
gut–brain
axis
has
implications
for
disorders
highlighting
potential
microbiota-derived
EVs
disease
progression.
Therapeutic
approaches
modulate
probiotics,
prebiotics,
microbial
transplants,
phage
therapy,
offer
promising
strategies
enhancing
performance.
Studies
investigating
effects
therapy
have
shown
results,
with
improving
food
safety
poultry
production
systems.
Understanding
complex
interactions
between
provides
valuable
insights
into
mechanisms
underlying
their
Further
research
this
field
essential
developing
effective
therapeutic
interventions
management
promote
well-being
animals.
