Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(36), С. 8605 - 8621
Опубликована: Янв. 1, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
that
causes
memory
and
cognitive
dysfunction
reduces
person's
decision-making
reasoning
functions.
AD
the
leading
cause
of
dementia
in
elderly.
Patients
with
have
increased
expression
pro-inflammatory
cytokines
nervous
system,
sustained
inflammatory
response
impairs
neuronal
function.
Meanwhile,
long-term
use
anti-inflammatory
drugs
can
reduce
incidence
to
some
extent.
This
confirms
anti-neuroinflammation
may
be
an
effective
treatment
for
AD.
Gold
nanoparticles
(AuNPs)
are
emerging
nanomaterial
promising
physicochemical
properties,
antioxidant.
AuNPs
neuroinflammation
by
inducing
macrophage
polarization
toward
M2
phenotype,
reducing
cytokine
expression,
blocking
leukocyte
adhesion,
decreasing
oxidative
stress.
Therefore,
gradually
attracting
interest
scholars
used
treating
diseases
drug
delivery.
Herein,
we
explored
role
mechanism
The
topic
worth
exploring
future,
not
only
help
solve
global
public
health
problem
but
also
provide
reference
other
neuroinflammatory
diseases.
Molecules,
Год журнала:
2021,
Номер
27(1), С. 132 - 132
Опубликована: Дек. 27, 2021
In
this
review,
we
comprehensively
describe
catalyzed
multicomponent
reactions
(MCRs)
and
the
multiple
roles
of
catalysis
combined
with
key
parameters
to
perform
these
transformations.
Besides
improving
yields
shortening
reaction
times,
is
vital
achieving
greener
protocols
furthering
MCR
field
research.
Considering
that
MCRs
typically
have
two
or
more
possible
pathways
explain
transformation,
essential
for
selecting
a
route
avoiding
byproduct
formation.
Key
parameters,
such
as
temperature,
catalyst
amounts
reagent
quantities,
were
analyzed.
Solvent
effects,
which
are
likely
most
neglected
topic
in
MCRs,
well
their
catalysis,
critically
discussed.
Stereocontrolled
rarely
observed
without
presence
catalytic
system,
also
presented
discussed
review.
Perspectives
on
use
systems
improved
finally
presented.
