International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1699 - 1707
Опубликована: Фев. 1, 2024
Introduction:
The
presence
of
cancer
stem
cells
(CSCs)
significantly
limits
the
therapeutic
efficacy
radiotherapy
(RT).
Efficient
elimination
potential
CSCs
is
crucial
for
enhancing
effectiveness
RT.
Methods:
In
this
study,
we
developed
a
biomimetic
hybrid
nano-system
(PMC)
composed
MnCO
3
as
inner
core
and
platelet
membrane
(PM)
outer
shell.
By
exploiting
specific
recognition
properties
surface
proteins,
PMC
enables
precise
targeting
CSCs.
Sonodynamic
therapy
(SDT)
was
employed
using
manganese
carbonate
nanoparticles
(MnCO
NPs),
which
generate
abundant
reactive
oxygen
species
(ROS)
upon
ultrasound
(US)
irradiation,
thereby
impairing
CSC
self-renewal
capacity
eradicating
Subsequent
RT
effectively
eliminates
common
tumor
cells.
Results:
Both
in
vitro
cell
experiments
vivo
animal
studies
demonstrate
that
SDT
mediated
by
synergistically
enhances
to
selectively
combat
while
inhibiting
growth
without
noticeable
side
effects.
Discussion:
Our
findings
offer
novel
insights
safety
profiles
Keywords:
clearance,
radiosensitization,
membrane,
sonodynamic
therapy,
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(23)
Опубликована: Март 6, 2023
Abstract
It
is
an
urgent
need
that
defect
repair
can
develop
from
simple
device
fixation
to
living
tissue
reconstruction,
short
life
function
replacement
permanent
regeneration
repair.
At
present,
bone
transplantation
has
become
the
second
largest
surgery
after
blood
transfusion,
and
artificial
generates
great
hope
for
treatment
of
defect.
In
order
defect,
must
have
good
biological
properties
sufficient
mechanical
properties,
it
should
also
shape
matching
site
connected
porous
structure.
For
structures
requirements
bone,
in
this
review
three
major
challenges
faced
by
are
systemtically
analyzed
current
methods
strategies
address
these
issues
discussed:
1)
developing
a
type
scaffold
material
with
both
2)
realizing
controllable
fabrication
individual
multistage
pore
structure
scaffold,
3)
transformation
man‐made
Besides,
summarizes
advantages
disadvantages
discusses
potential
future
directions
structural
functional
adaptive
regeneration.
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
International Journal of Extreme Manufacturing,
Год журнала:
2023,
Номер
6(1), С. 015101 - 015101
Опубликована: Окт. 10, 2023
Highlights
High-energy
ball
milling
was
proposed
to
construct
oxygen
vacancy
defects.
Scaffold
with
individualized
shape
and
porous
structure
fabricated
by
selective
laser
sintering.
Antibacterial
material
used
adsorb
H
2
O
the
site
of
bacterial
infection.
The
accumulated
could
amplify
Fenton
reaction
efficiency
induce
more
·OH.
scaffold
possessed
matched
mechanical
properties
good
biocompatibility.
International Journal of Extreme Manufacturing,
Год журнала:
2023,
Номер
5(3), С. 032012 - 032012
Опубликована: Июнь 15, 2023
Abstract
As
a
new
generation
of
materials/structures,
heterostructure
is
characterized
by
heterogeneous
zones
with
dramatically
different
mechanical,
physical
or
chemical
properties.
This
endows
unique
interfaces,
robust
architectures,
and
synergistic
effects,
making
it
promising
option
as
advanced
biomaterials
for
the
highly
variable
anatomy
complex
functionalities
individual
patients.
However,
main
challenges
developing
lie
in
control
crystal/phase
evolution
distribution/fraction
components
structures.
In
recent
years,
additive
manufacturing
techniques
have
attracted
increasing
attention
due
to
flexibility
tailored
structures
synthetic
multimaterials.
review
focuses
on
biomedical
applications.
The
structural
features
functional
mechanisms
are
summarized.
typical
material
systems
heterostructure,
mainly
including
metals,
polymers,
ceramics,
their
composites,
presented.
And
resulting
effects
multiple
properties
also
systematically
discussed
terms
biocompatible,
biodegradable,
antibacterial,
biosensitive
magnetostrictive
Next,
this
work
outlines
research
progress
employed
from
aspects
advantages,
processes,
properties,
highlights
prospective
utilization
fields,
particular
bioscaffolds,
vasculatures,
biosensors
biodetections.
Finally,
future
directions
breakthroughs
prospected
focus
more
applications
infection
prevention
drug
delivery.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 9, 2024
Extensive
research
on
zeolitic
imidazolate
framework
(ZIF-8)
and
its
derivatives
has
highlighted
their
unique
properties
in
nanomedicine.
ZIF-8
exhibits
advantages
such
as
pH-responsive
dissolution,
easy
surface
functionalization,
efficient
drug
loading,
making
it
an
ideal
nanosystem
for
intelligent
delivery
phototherapy.
These
characteristics
have
sparked
significant
interest
potential
applications
tissue
regeneration,
particularly
bone,
skin,
nerve
regeneration.
This
review
provides
a
comprehensive
assessment
of
ZIF-8’s
feasibility
engineering,
encompassing
material
synthesis,
performance
testing,
the
development
multifunctional
nanosystems.
Furthermore,
latest
advancements
field,
well
limitations
future
prospects,
are
discussed.
Overall,
this
emphasizes
developments
engineering
highlights
nanoplatforms
effective
complex
repair.
