A bacterial biosensor based on gold nanoparticles functionalized by a hydrophobin-chimera and combined with machine learning for user-friendly detection DOI Creative Commons

Anna Pennacchio,

Fabio Giampaolo, Valeria Cafaro

и другие.

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 410, С. 135645 - 135645

Опубликована: Март 14, 2024

A chimeric protein, in which a cationic antimicrobial peptide was fused to the adhesive self-assembling moiety of fungal class I hydrophobin, produced and used easily functionalize gold nanoparticles (f-AuNPs). f-AuNPs are able bind Escherichia coli Staphylococcus epidermidis bacteria, tested as model organisms. reverse colorimetric assay then set up based on induced aggregation free f-AuNPs. This leads changes optical properties solution, visible even by naked eyes. approach allows detection 10 CFU mL-1 E. within 15 min can be applicable detect bacterial contamination real matrices. Notably, variation combined machine-learning methodologies inferring data from photos colored solutions, acquired smartphones. fast, highly practical flexible system, would enable on-site measurements and, therefore, help prevent significant contaminations.

Язык: Английский

Applications of Green Synthesized Metal Nanoparticles — a Review DOI Open Access
Seerengaraj Vijayaram, Hary Razafindralambo, Yun‐Zhang Sun

и другие.

Biological Trace Element Research, Год журнала: 2023, Номер 202(1), С. 360 - 386

Опубликована: Апрель 13, 2023

Язык: Английский

Процитировано

284

Multifunctional surface functionalized magnetic iron oxide nanoparticles for biomedical applications: A review DOI Creative Commons

Rutuja Prashant Gambhir,

Sonali S. Rohiwal, Arpita Tiwari

и другие.

Applied Surface Science Advances, Год журнала: 2022, Номер 11, С. 100303 - 100303

Опубликована: Сен. 18, 2022

Magnetic iron oxide nanoparticle-based multifunctional platforms have been explored extensively in biomedical applications. Modifications and integrations of IONPs with different entities viz. organic polymer, doping inorganic materials, loading drug, fluorescent dye, or antibodies make them appropriate for their application broad spectrum fields. This review presents summarizes the fabrication strategies magnetic nanoparticles based on modification surface functionalization MNP. Multifunctional recent advances covering a wide array applications like biosensing pathogen detection, resonance imaging (MRI) biomarker tracking, magnetofection gene therapy, hyperthermia chemotherapy, drug delivery targeted cell killing, bioimaging therapeutics, stem detection tissue engineering organ transplant, nano-vaccines immune system activation, microbe targeting destruction, COVID19 management are also covered.

Язык: Английский

Процитировано

82

Green synthesis of gold nanoparticles via Capsicum annum fruit extract: Characterization, antiangiogenic, antioxidant and anti-inflammatory activities DOI Creative Commons

Tejaswini P. Patil,

Anuja Vibhute,

Snehal L. Patil

и другие.

Applied Surface Science Advances, Год журнала: 2023, Номер 13, С. 100372 - 100372

Опубликована: Янв. 18, 2023

Biological synthesis of gold nanoparticles (AuNPs) is gaining attention researchers because their varieties biomedical applications. This study reported the novel, eco-friendly AuNPs using dried fruit extract Capsicum annum (C. annum). Biosynthesized (Ca-AuNPs) showed UV absorption peak at 540 nm and were found to be stable for up three months. The further characterized by Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FT-IR), Energy Dispersive X-ray Analysis (EDAX) diffraction (XRD) analysis. spherical in shape with size range 20–30 zeta potential confirmed surface charge -26.5 mV. Ca-AuNPs tested anti-angiogenic activity Chorioallantoic membrane (CAM) assay that implied a significant efficiency 100 µg/mL concentration. antioxidant studied 2,2- diphenyl-1-picrylhydrazyl (DPPH) was 86.0% radical scavenging activity. These also revealed anti-inflammatory concentration 100–1200 IC-50 value619.4 µg/mL. present includes phytoconstituents plant material as reducing agents efficiently exploit applications nanoparticles.

Язык: Английский

Процитировано

65

A comprehensive review on nanofluids: Synthesis, cutting-edge applications, and future prospects DOI Creative Commons
Habib Ben Bacha, Naeem Ullah,

Aamir Hamid

и другие.

International Journal of Thermofluids, Год журнала: 2024, Номер 22, С. 100595 - 100595

Опубликована: Фев. 9, 2024

Nanofluids, which are fluid suspensions containing nanoparticles, exhibit remarkable property enhancements even at low nanoparticle concentrations. Much of the research on nanofluids aims to understand their behavior for applications where heat transfer enhancement is crucial, spanning industrial, nuclear, transportation, electronics, biomedical, and food sectors. Notably, can act as smart fluids, allowing controlled modulation transfer. This paper presents an overview recent advances in nanofluid research, covering preparation techniques a wide range existing potential energy, mechanical engineering, biomedicine. Furthermore, highlights avenues future this field. In light findings, concludes that comprehensive hybrid model understanding thermophysical properties lacking. Further exploration additional unexplored aspects, particularly deemed essential. To capture entirety our study, graphical abstract provides representation.

Язык: Английский

Процитировано

61

Advancements in nanomaterials for nanosensors: a comprehensive review DOI Creative Commons
Moustafa A. Darwish, Walaa Abd‐Elaziem, Ammar H. Elsheikh

и другие.

Nanoscale Advances, Год журнала: 2024, Номер 6(16), С. 4015 - 4046

Опубликована: Янв. 1, 2024

Nanomaterials (NMs) exhibit unique properties that render them highly suitable for developing sensitive and selective nanosensors across various domains.

Язык: Английский

Процитировано

60

Gold nanoparticles (AuNPs): A versatile material for biosensor application DOI Creative Commons
Meiyanti Ratna Kumalasari, Rokiy Alfanaar, Agustina Sus Andreani

и другие.

Talanta Open, Год журнала: 2024, Номер 9, С. 100327 - 100327

Опубликована: Май 16, 2024

Gold nanoparticles (AuNPs) have become the focus of rapid research due to their unique optical and electronic properties. There has been a noticeable increase in papers relating AuNPs, with over 71,000 publications between 2019 2024. AuNPs possess exceptional stability, low resistance, high conductivity, extensive light interaction, making them well-suited for biological sensing applications. This literature study begins by examining different approaches synthesizing including chemical, physical, methods, before exploring use as biosensors. A comprehensive examination various detection localized surface plasmon resonance (LSPR), luminescence, surface-enhanced Raman scattering (SERS), (SPR), electrochemical properties, is facilitated through an exploration fundamental principles classification We primarily on using medical diagnostics, highlighting current advancements disease AuNPs-based biosensors conditions like COVID-19, dengue fever, diabetes. The review emphasizes achievements synthesis bright prospects biocompatible efficient biosensor

Язык: Английский

Процитировано

50

Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Язык: Английский

Процитировано

25

Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy DOI Creative Commons

Joel Georgeous,

Nour AlSawaftah, Waad H. Abuwatfa

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332

Опубликована: Окт. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Язык: Английский

Процитировано

24

Advancements in wearable sensors for cardiovascular disease detection for health monitoring DOI
Bangul Khan, Zainab Riaz, Rafi u Shan Ahmad

и другие.

Materials Science and Engineering R Reports, Год журнала: 2024, Номер 159, С. 100804 - 100804

Опубликована: Май 21, 2024

Язык: Английский

Процитировано

20

Recent Advances in Monodisperse Gold Nanoparticle Delivery, Synthesis, and Emerging Applications in Cancer Therapy DOI

Shamim Shamim,

Shahzad Ali, Tarmeen Ali

и другие.

Plasmonics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Язык: Английский

Процитировано

3